TEST BANK
Principles of Pharmacology for Respiratory Care
Georgine Bills, and Christina Rose
3rd Edition
,Table of Contents
Chapter 01 Introduction to Medication Information Development and Regulation 1
Chapter 02 General Pharmacological Concepts 6
Chapter 03 Introduction to the Pharmacology of the Atomic Nervous System 12
Chapter 04 Dose Calculations and Problem Solving 18
Chapter 05 Administration of Aerosolized and Instilled Medications 25
Chapter 06 Bronchodilator Therapy 31
Chapter 07 Anti-Inflammatory Drugs Used in Respiratory Diseases 37
Chapter 08 Wetting Agents and Mucoactive Drugs 43
Chapter 09 Surfactant Agents 49
Chapter 10 Aerosolized Antimicrobial Therapy 56
Chapter 11 Agents Used in Special Procedures and of Pulmonary Importance 62
Chapter 12 Critical Care Pharmacology and Advanced Cardiac Life Support 69
Chapter 13 Cardiovascular and Renal Pharmacology 76
Chapter 14 Pharmacology of the Central Nervous System 83
Chapter 15 Pharmacology of the Endocrine System 90
Chapter 16 Antimicrobial Pharmacology 97
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Chapter 01 Introduction to Medication Information Development and Regulation
Multiple Choice
1. Which of the following would be an example of a placebo?
A. Aspirin causing a decrease in platelet activity
B. Inhaled albuterol causing bronchodilation
C. A substance that has no active ingredient but, when taken, the patient perceives decreased
pain
D. An antibiotic that treats a urinary tract infection
Answer: C
Complexity: Moderate
Ahead: Introduction
Subject: Chapter 1
2. A drug, para-acetylaminophenol, is marketed at Tylenol (acetaminophen) and used to treat
fever. Which of the following is considered the generic name?
A. Para-acetylaminophenol
B. Tylenol
C. Acetaminophen
D. Feverall
Answer: C
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
3. Which of the following is an example of drug tolerance?
A. An antibiotic requiring a dose increase due to increased weight of a patient
B. An increased dose of a sedative medication is required to effectively cause sleep
C. A blood pressure medication dose is decreased due to causing dizziness
D. A medication dose is decreased due to kidney failure
Answer: B
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
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1|Page
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
4. Which of the following would be considered an adverse drug reaction?
A. An antibiotic that fails to cure an infection
B. An antihypertensive agent that lowers blood pressure
C. An analgesic that treats pain
D. A drug used to treat cancer that causes heart failure
Answer: D
Complexity: Moderate
Ahead: Introduction
Subject: Chapter 1
5. Which of the following drugs would be considered a teratogen?
A. Tetracyclines, which may cause teeth discoloration in the fetus
B. Valproic acid, which may cause a cleft palate of the fetus
C. Amiodarone, which may cause hyperthyroidism in the fetus
D. All of these are correct.
Answer: D
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
6. Which of the following phases of drug development does not involve testing in humans?
A. In-vitro
B. Phase I
C. Phase II
D. Phase III
Answer: A
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
7. Which of the following phases of drug development occurs in healthy human subjects and
tests the tolerability of the drug?
A. Phase I
B. Phase II
C. Phase III
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
D. Phase IV
Answer: A
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
8. Which of the following phases of drug development is the limiting factor, or last phase
required, before approval for use by the Food and Drug Administration?
A. Phase I
B. Phase II
C. Phase III
D. Phase IV
Answer: C
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
9. Which of the following drug information resources is not updated every year?
A. AHFS Drug Information
B. United States Pharmacopeia
C. Physicians’ Desk Reference
D. Drug Information Handbook
Answer: B
Complexity: Easy
Ahead: Sources of Drug Information
Subject: Chapter 1
10. Which of the following drug information resources would include off-label (non–FDA-
approved) indications?
A. United States Pharmacopeia
B. Physicians’ Desk Reference
C. National Formulary
D. AHFS Drug information
Answer: D
Complexity: Easy
Ahead: Sources of Drug Information
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Subject: Chapter 1
11. Which of the following would be considered a schedule I controlled substance and is not
available by prescription?
A. Heroin
B. Morphine
C. Codeine
D. Alprazolam
Answer: A
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
12. Drugs listed under which the following schedules of controlled substances are unable to be
refilled without a new prescription?
A. Schedule I
B. Schedule II
C. Schedule III
D. Schedule IV
Answer: B
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
13. Which of the following types of medications has the lowest potential to be abused?
A. Schedule II
B. Schedule III
C. Schedule IV
D. Schedule V
Answer: D
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
14. Prescribers must be registered with which organization in order to write prescriptions for
controlled substances?
A. United States Pharmacopeia
B. Drug Enforcement Agency
C. American Society of Health System Pharmacists
D. The drug manufacturer
Answer: B
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
True/False
15. True or False? A new derivative of morphine has been manufactured to treat pain more
effectively. Because this is a new drug, it would not be considered a controlled substance.
Answer: False
Complexity: Moderate
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
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5|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Chapter 02 General Pharmacological Concepts
Multiple Choice
1. Which of the following routes of medication administration is the most convenient and safest
for patients?
A. Oral
B. Subcutaneous
C. Intramuscular
D. Intravenous
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
2. Which of the following routes of administration is used in order to exert a direct medication-
related effect to the site of administration?
A. Oral
B. Inhalation
C. Sublingual
D. Intravenous
Answer: B
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
3. Which of the following routes of administration will have slowest onset of effect?
A. Oral
B. Intravenous
C. Sublingual
D. Inhaled
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
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6|Page
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Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
4. Given the therapeutic index, which of the following drugs would be considered the safest?
Drug A: TI = 0.5
Drug B: TI = 10
Drug C: TI = 210
A. Drug A
B. Drug B
C. Drug C
D. They are all equal.
Answer: C
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
5. Which of the following drug properties will lead to increased drug absorption?
A. Large molecule
B. Hydrophilic
C. Weak acid in the unionized form
D. Strong base
Answer: C
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
6. Which of the following drugs would be considered a receptor agonist?
Albuterol: exerts its effect by acting on the beta-2 receptor
Ipratropium: exerts its effect by blocking the activity of acetylcholine on the muscarinic receptor
Flumazenil: blocks the activity of benzodiazepines on the GABA receptors
A. Albuterol
B. Ipratropium
C. Flumazenil
D. None of these is correct.
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
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7|Page
, ______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
7. Which of the following organs is most commonly responsible for biotransformation or
metabolism?
A. Lungs
B. Liver
C. Pancreas
D. Kidneys
Answer: B
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
8. Ritonavir, an anti-retroviral used in the treatment of human immunodeficiency virus (HIV),
inhibits the metabolism of fluticasone, an inhaled corticosteroid. What do you predict would
happen to the effects of fluticasone if it is taken with ritonavir?
A. Increase
B. Decrease
C. Stay the same
Answer: A
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
9. Which of the following processes is not involved in the study of pharmacokinetics?
A. Absorption
B. Distribution
C. Metabolism
D. Receptor activity
Answer: D
Complexity:
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
10. Which of the following routes of administration is used for poorly water-soluble drugs and
involves injection into the muscle?
A. Intra-arterial
B. Sublingual
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8|Page
Principles of Pharmacology for Respiratory Care
Georgine Bills, and Christina Rose
3rd Edition
,Table of Contents
Chapter 01 Introduction to Medication Information Development and Regulation 1
Chapter 02 General Pharmacological Concepts 6
Chapter 03 Introduction to the Pharmacology of the Atomic Nervous System 12
Chapter 04 Dose Calculations and Problem Solving 18
Chapter 05 Administration of Aerosolized and Instilled Medications 25
Chapter 06 Bronchodilator Therapy 31
Chapter 07 Anti-Inflammatory Drugs Used in Respiratory Diseases 37
Chapter 08 Wetting Agents and Mucoactive Drugs 43
Chapter 09 Surfactant Agents 49
Chapter 10 Aerosolized Antimicrobial Therapy 56
Chapter 11 Agents Used in Special Procedures and of Pulmonary Importance 62
Chapter 12 Critical Care Pharmacology and Advanced Cardiac Life Support 69
Chapter 13 Cardiovascular and Renal Pharmacology 76
Chapter 14 Pharmacology of the Central Nervous System 83
Chapter 15 Pharmacology of the Endocrine System 90
Chapter 16 Antimicrobial Pharmacology 97
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Chapter 01 Introduction to Medication Information Development and Regulation
Multiple Choice
1. Which of the following would be an example of a placebo?
A. Aspirin causing a decrease in platelet activity
B. Inhaled albuterol causing bronchodilation
C. A substance that has no active ingredient but, when taken, the patient perceives decreased
pain
D. An antibiotic that treats a urinary tract infection
Answer: C
Complexity: Moderate
Ahead: Introduction
Subject: Chapter 1
2. A drug, para-acetylaminophenol, is marketed at Tylenol (acetaminophen) and used to treat
fever. Which of the following is considered the generic name?
A. Para-acetylaminophenol
B. Tylenol
C. Acetaminophen
D. Feverall
Answer: C
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
3. Which of the following is an example of drug tolerance?
A. An antibiotic requiring a dose increase due to increased weight of a patient
B. An increased dose of a sedative medication is required to effectively cause sleep
C. A blood pressure medication dose is decreased due to causing dizziness
D. A medication dose is decreased due to kidney failure
Answer: B
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
______________________________________________________________________________________________
1|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
4. Which of the following would be considered an adverse drug reaction?
A. An antibiotic that fails to cure an infection
B. An antihypertensive agent that lowers blood pressure
C. An analgesic that treats pain
D. A drug used to treat cancer that causes heart failure
Answer: D
Complexity: Moderate
Ahead: Introduction
Subject: Chapter 1
5. Which of the following drugs would be considered a teratogen?
A. Tetracyclines, which may cause teeth discoloration in the fetus
B. Valproic acid, which may cause a cleft palate of the fetus
C. Amiodarone, which may cause hyperthyroidism in the fetus
D. All of these are correct.
Answer: D
Complexity: Easy
Ahead: Introduction
Subject: Chapter 1
6. Which of the following phases of drug development does not involve testing in humans?
A. In-vitro
B. Phase I
C. Phase II
D. Phase III
Answer: A
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
7. Which of the following phases of drug development occurs in healthy human subjects and
tests the tolerability of the drug?
A. Phase I
B. Phase II
C. Phase III
______________________________________________________________________________________________
2|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
D. Phase IV
Answer: A
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
8. Which of the following phases of drug development is the limiting factor, or last phase
required, before approval for use by the Food and Drug Administration?
A. Phase I
B. Phase II
C. Phase III
D. Phase IV
Answer: C
Complexity: Easy
Ahead: Drug Development
Subject: Chapter 1
9. Which of the following drug information resources is not updated every year?
A. AHFS Drug Information
B. United States Pharmacopeia
C. Physicians’ Desk Reference
D. Drug Information Handbook
Answer: B
Complexity: Easy
Ahead: Sources of Drug Information
Subject: Chapter 1
10. Which of the following drug information resources would include off-label (non–FDA-
approved) indications?
A. United States Pharmacopeia
B. Physicians’ Desk Reference
C. National Formulary
D. AHFS Drug information
Answer: D
Complexity: Easy
Ahead: Sources of Drug Information
______________________________________________________________________________________________
3|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Subject: Chapter 1
11. Which of the following would be considered a schedule I controlled substance and is not
available by prescription?
A. Heroin
B. Morphine
C. Codeine
D. Alprazolam
Answer: A
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
12. Drugs listed under which the following schedules of controlled substances are unable to be
refilled without a new prescription?
A. Schedule I
B. Schedule II
C. Schedule III
D. Schedule IV
Answer: B
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
13. Which of the following types of medications has the lowest potential to be abused?
A. Schedule II
B. Schedule III
C. Schedule IV
D. Schedule V
Answer: D
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
______________________________________________________________________________________________
4|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
14. Prescribers must be registered with which organization in order to write prescriptions for
controlled substances?
A. United States Pharmacopeia
B. Drug Enforcement Agency
C. American Society of Health System Pharmacists
D. The drug manufacturer
Answer: B
Complexity: Easy
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
True/False
15. True or False? A new derivative of morphine has been manufactured to treat pain more
effectively. Because this is a new drug, it would not be considered a controlled substance.
Answer: False
Complexity: Moderate
Ahead: Abuse of Prescription Drugs
Subject: Chapter 1
______________________________________________________________________________________________
5|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
Chapter 02 General Pharmacological Concepts
Multiple Choice
1. Which of the following routes of medication administration is the most convenient and safest
for patients?
A. Oral
B. Subcutaneous
C. Intramuscular
D. Intravenous
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
2. Which of the following routes of administration is used in order to exert a direct medication-
related effect to the site of administration?
A. Oral
B. Inhalation
C. Sublingual
D. Intravenous
Answer: B
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
3. Which of the following routes of administration will have slowest onset of effect?
A. Oral
B. Intravenous
C. Sublingual
D. Inhaled
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
______________________________________________________________________________________________
6|Page
,______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
4. Given the therapeutic index, which of the following drugs would be considered the safest?
Drug A: TI = 0.5
Drug B: TI = 10
Drug C: TI = 210
A. Drug A
B. Drug B
C. Drug C
D. They are all equal.
Answer: C
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
5. Which of the following drug properties will lead to increased drug absorption?
A. Large molecule
B. Hydrophilic
C. Weak acid in the unionized form
D. Strong base
Answer: C
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
6. Which of the following drugs would be considered a receptor agonist?
Albuterol: exerts its effect by acting on the beta-2 receptor
Ipratropium: exerts its effect by blocking the activity of acetylcholine on the muscarinic receptor
Flumazenil: blocks the activity of benzodiazepines on the GABA receptors
A. Albuterol
B. Ipratropium
C. Flumazenil
D. None of these is correct.
Answer: A
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
______________________________________________________________________________________________
7|Page
, ______________________________________________________________________________________________
Test Bank - Principles of Pharmacology for Respiratory Care, 3rd Edition (Bills, 2021)
7. Which of the following organs is most commonly responsible for biotransformation or
metabolism?
A. Lungs
B. Liver
C. Pancreas
D. Kidneys
Answer: B
Complexity: Easy
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
8. Ritonavir, an anti-retroviral used in the treatment of human immunodeficiency virus (HIV),
inhibits the metabolism of fluticasone, an inhaled corticosteroid. What do you predict would
happen to the effects of fluticasone if it is taken with ritonavir?
A. Increase
B. Decrease
C. Stay the same
Answer: A
Complexity: Moderate
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
9. Which of the following processes is not involved in the study of pharmacokinetics?
A. Absorption
B. Distribution
C. Metabolism
D. Receptor activity
Answer: D
Complexity:
Ahead: Essential General Principles of Pharmacology
Subject: Chapter 2
10. Which of the following routes of administration is used for poorly water-soluble drugs and
involves injection into the muscle?
A. Intra-arterial
B. Sublingual
______________________________________________________________________________________________
8|Page
