ONS CHEMOTHERAPY IMMUNOTHERAPY
CERTIFICATE EXAM Questions with 100%
Correct Answers Latest Updates 2025 A+
How does hormone therapy work? - Precise Answer ✔✔Attempts to
add, block, or remove hormones from the body to interrupt cancer cell
division
LHRH antagonists MOA - Precise Answer ✔✔Directly inhibits pituitary
from releasing LH and FSH
*No tumor flare
LHRH agonists MOA - Precise Answer ✔✔Produce an initial increase
in LH and FSH, which can cause a flare. Then lower testosterone made
by testicles and estrogen & progesterone made by ovaries
*Prostate cancer
*Estrogen receptor-positive, premenopausal metastatic breat cancer
Most common type of breast cancer - Precise Answer ✔✔Hormone
receptor (HR)-positive breast cancer
,Aromatase inhibitors MOA - Precise Answer ✔✔Block the enzyme
aromatase, which turns the hormone androgen into small amounts of
estrogen in the body
**Less estrogen is available to stimulate growth of HR-positive breast
cancer cells
2 types of aromatase inhibitors - Precise Answer ✔✔1. Steroidal
(irreversible)
2. Nonsteroidal (reversible)
3 aromatase inhibitors - Precise Answer ✔✔Anastrozole
Letrozole
Exemestane
Common side effects of aromatase inhibitors (AI): - Precise Answer
✔✔Fatigue
N/V*
Weakness
HA*
Insomnia
Dizziness
Hot flashes*
Weight gain*
, Higher cholesterol
Increased sweating*
Bone/joint pain*
Selective ER downregulators (SERDs) MOA - Precise Answer
✔✔Binding to and degrading ER
Common SERD - Precise Answer ✔✔Fulvestrant
Selective ER modulators (SERMs) MOA - Precise Answer ✔✔Blocking
and downregulating ERs
*Can function as ER agonists, antagonists, or mixed agonist-antagonists
*Can activate or block estrogen
Common SERMs - Precise Answer ✔✔Tamoxifen
Raloxifine
Bazedoxifine
Antiandrogens MOA - Precise Answer ✔✔Keeps androgens from
binding to androgen receptors found in prostate cancer cells (and in
some other tissue cells)
CERTIFICATE EXAM Questions with 100%
Correct Answers Latest Updates 2025 A+
How does hormone therapy work? - Precise Answer ✔✔Attempts to
add, block, or remove hormones from the body to interrupt cancer cell
division
LHRH antagonists MOA - Precise Answer ✔✔Directly inhibits pituitary
from releasing LH and FSH
*No tumor flare
LHRH agonists MOA - Precise Answer ✔✔Produce an initial increase
in LH and FSH, which can cause a flare. Then lower testosterone made
by testicles and estrogen & progesterone made by ovaries
*Prostate cancer
*Estrogen receptor-positive, premenopausal metastatic breat cancer
Most common type of breast cancer - Precise Answer ✔✔Hormone
receptor (HR)-positive breast cancer
,Aromatase inhibitors MOA - Precise Answer ✔✔Block the enzyme
aromatase, which turns the hormone androgen into small amounts of
estrogen in the body
**Less estrogen is available to stimulate growth of HR-positive breast
cancer cells
2 types of aromatase inhibitors - Precise Answer ✔✔1. Steroidal
(irreversible)
2. Nonsteroidal (reversible)
3 aromatase inhibitors - Precise Answer ✔✔Anastrozole
Letrozole
Exemestane
Common side effects of aromatase inhibitors (AI): - Precise Answer
✔✔Fatigue
N/V*
Weakness
HA*
Insomnia
Dizziness
Hot flashes*
Weight gain*
, Higher cholesterol
Increased sweating*
Bone/joint pain*
Selective ER downregulators (SERDs) MOA - Precise Answer
✔✔Binding to and degrading ER
Common SERD - Precise Answer ✔✔Fulvestrant
Selective ER modulators (SERMs) MOA - Precise Answer ✔✔Blocking
and downregulating ERs
*Can function as ER agonists, antagonists, or mixed agonist-antagonists
*Can activate or block estrogen
Common SERMs - Precise Answer ✔✔Tamoxifen
Raloxifine
Bazedoxifine
Antiandrogens MOA - Precise Answer ✔✔Keeps androgens from
binding to androgen receptors found in prostate cancer cells (and in
some other tissue cells)
