PHM 431 EXAM QUESTIONS AND
ANSWERS
Most monoamines in our diet are detoxified or inactivated by several protective
mechanisms that include: - Answer-High expression of liver monoamine oxidase
Amphetamines are strong appetite suppressant drugs. The brain area that mediates this
action of amphetamine is: - Answer-hypothalamus
A major consequence of a cocaine or amphetamine overdose is cardiac arrhythmia.
Cocaine is more lethal than amphetamine in this regard because: - Answer-Cocaine
blocks sodium channels in cardiac muscle
Cocaine is an unusual drug because laboratory rats develop long lasting sensitization to
the psychostimulant effects of cocaine after repeated cocaine treatments. Which of the
following treatments would block this behavioral sensitization? - Answer-Knockout of the
gene encoding brain derived neurotrophic factor
Hyperthermia is a toxicity caused by recreational use of which of the following drugs? -
Answer-3,4-Methylene-dioxymethamphetamine
A unique feature of chronic cocaine use is sensitization (rather than tolerance) to
cocaine's effects. A "knockout" of which of the following genes in a laboroatory mouse
would reduce behavioral sensitization to the effects of repeated cocaine administration.
- Answer-deltaFosB
The principal target for the addictive actions of cocaine is: - Answer-The dopamine
transporter in the nulceus accumbens
The figure above show the results of a positron emission tomography experiment done
in drug inexperienced subjects. These subjects were administered drugs and 11C-
raclopride binding in the nucleus accumbens was used as indirect measure of
dopamine release in response to drug treatment. Which of the drugs listed below would
you expect to produce the results shown in the figure?
A amphetamine
B cocaine
C Methylphenidate
D all of the above - Answer-D all of the above
Which of the following drug combinations would be most likely to cause cross
tolerance? - Answer-Caffeine and theobromine
ANSWERS
Most monoamines in our diet are detoxified or inactivated by several protective
mechanisms that include: - Answer-High expression of liver monoamine oxidase
Amphetamines are strong appetite suppressant drugs. The brain area that mediates this
action of amphetamine is: - Answer-hypothalamus
A major consequence of a cocaine or amphetamine overdose is cardiac arrhythmia.
Cocaine is more lethal than amphetamine in this regard because: - Answer-Cocaine
blocks sodium channels in cardiac muscle
Cocaine is an unusual drug because laboratory rats develop long lasting sensitization to
the psychostimulant effects of cocaine after repeated cocaine treatments. Which of the
following treatments would block this behavioral sensitization? - Answer-Knockout of the
gene encoding brain derived neurotrophic factor
Hyperthermia is a toxicity caused by recreational use of which of the following drugs? -
Answer-3,4-Methylene-dioxymethamphetamine
A unique feature of chronic cocaine use is sensitization (rather than tolerance) to
cocaine's effects. A "knockout" of which of the following genes in a laboroatory mouse
would reduce behavioral sensitization to the effects of repeated cocaine administration.
- Answer-deltaFosB
The principal target for the addictive actions of cocaine is: - Answer-The dopamine
transporter in the nulceus accumbens
The figure above show the results of a positron emission tomography experiment done
in drug inexperienced subjects. These subjects were administered drugs and 11C-
raclopride binding in the nucleus accumbens was used as indirect measure of
dopamine release in response to drug treatment. Which of the drugs listed below would
you expect to produce the results shown in the figure?
A amphetamine
B cocaine
C Methylphenidate
D all of the above - Answer-D all of the above
Which of the following drug combinations would be most likely to cause cross
tolerance? - Answer-Caffeine and theobromine
