TEST BANK
Basic and Clinical Pharmacology, 15th Edition by Bertram G.
Katzung, Anthony J. Trevor
, Page`2`of`822
Basic`and`Clinical`Pharmacology`15th`Edition`Katzung`Trevor`Test` Bank
Chapter`1.`Introduction:`The`Nature`of`Drugs`&`Drug`Development`&`Regulation
1.
A`nurse`working`in`radiology`administers`iodine`to`a`patient`who`is`having`
a`computed`tomography`(CT)`scan.`The`nurse`working`on`the`oncology`unit`a
dministers`chemotherapy`to`patients`who`have`cancer.`At`the`Public`Health`D
epartment,`a`nurse`administers`a`measles-mumps-
rubella`(MMR)`vaccine`to`a`14-month-
old`child`as`a`routine`immunization.`Which`branch`of`pharmacology`best`desc
ribes`the`actions`of`all`three` nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology`is`the`study`of`the`biologic`effects`of`chemicals.`Nurses`are`inv
olved`with`clinical`pharmacology`or`pharmacotherapeutics,`which`is`a`branch
`of`pharmacology`that`deals`with`the`uses`of`drugs`to`treat,`prevent,`and`diagn
ose`disease.`The`radiology`nurse`is`administering`a`drug`to`help`diagnose`a`di
sease.`The`oncology`nurse`is`administering`a`drug`to`help`treat`a`disease.`Phar
macoeconomics`includes`any`costs`involved`in`drug`therapy.
Pharmacodynamics`involves`how`a`drug`affects`the`body`and`pharmacokinetic
s`is`how`the`body`acts`on`the`body.
2.
When`involved`in`phase`III`drug`evaluation`studies,`what`responsibiliti
es`would`the`nurse`have?
A) Working`with`animals`who`are`given`experimental` drugs
B) Choosing`appropriate`patients`to`be`involved`in`the`drug` study
www.stuvia.com
, Page`3`of`822
C) Monitoring`and`observing`patients`closely`for`adverse` effects
D) Conducting`research`to`determine`effectiveness`of`the` drug
Ans: C
Feedback:
Phase`III`studies`involve`use`of`a`drug`in`a`vast`clinical`population`in`which`p
atients`are`asked`to`record`any`symptoms`they`experience`while`taking`the`dr
ugs.`Nurses`may`be`responsible`for`helping`collect`and`analyze`the`informati
on`to`be`shared`with`the`Food`and`Drug`Administration`(FDA)`but`would`not`
conduct`research`independently`because`nurses`do`not`prescribe`medications.
`Use`of`animals`in`drug`testing`is`done`in`the`preclinical`trials.`Select`patients`
who`are`involved`in`phase`II`studies`to`participate`in`studies`where`the`partici
pants`have`the`disease`the`drug`is`intended`to`treat.`These`patients`are`monito
red`closely`for`drug`action`and`adverse`effects.`Phase`I`studies`involve`health
y`human`volunteers`who`are`usually`paid`for`their`participation.`Nurses`may`
observe`for`adverse`effects`and`toxicity.
3.
A`physician`has`ordered`intramuscular`(IM)`injections`of`morphine,`a`narc
otic,`every`4`hours`as`needed`for`pain`in`a`motor`vehicle`accident`victim.`The`
nurse`is`aware`this`drug`has`a`high`abuse`potential.`Under`what`category`wou
ld`morphine`be`classified?
A) Schedule`I
B) Schedule`II
C) Schedule`III
D) Schedule`IV
Ans: B
Feedback:
Narcotics`with`a`high`abuse`potential`are`classified`as`Schedule`II`drugs`beca
use`of`severe`dependence`liability.`Schedule`I`drugs`have`high`abuse`potenti
al`and`no`accepted`medical`use.`Schedule`III`drugs`have`a`lesser`abuse`poten
tial`than`II`and`an`accepted`medical`use.`Schedule`IV`drugs`have`low`abuse`p
otential`and`limited`dependence`liability.
www.stuvia.com
, Page`4`of`822
4.
What`concept`is`considered`when`generic`drugs`are`substituted`for`bra
nd`name`drugs?
A) Bioavailability
B) Critical`concentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability`is`the`portion`of`a`dose`of`a`drug`that`reaches`the`systemic`cir
culation`and`is`available`to`act`on`body`cells.`Binders`used`in`a`generic`drug`
may`not`be`the`same`as`those`used`in`the`brand`name`drug.`Therefore,`the`wa
y`the`body`breaks`down`and`uses`the`drug`may`differ,`which`may`eliminate`a
`generic`drug`substitution.`Critical`concentration`is`the`amount`of`a`drug`that`
is`needed`to`cause`a`therapeutic`effect`and`should`not`differ`between`generic`
and`brand`name`medications.`Distribution`is`the`phase`of`pharmacokinetics,`
which`involves`the`movement`of`a`drug`to`the`bodys`tissues`and`is`the`same`i
n`generic`and`brand`name`drugs.`A`drugs`half-
life`is`the`time`it`takes`for`the`amount`of`drug`to`decrease`to`half`the`peak`lev
el,`which`should`not`change`when`substituting`a`generic` medication.
5.
A`nurse`is`assessing`the`patients`home`medication`use.`After`listening`to`t
he`patient`list`current`medications,`the`nurse`asks`what`priority`question?
A) Do`you`take`any`generic`medications?
B) Are`any`of`these`medications`orphan` drugs?
C) Are`these`medications`safe`to`take`during` pregnancy?
D) Do`you`take`any`over-the-counter` medications?
Ans: D
Feedback:
www.stuvia.com
Basic and Clinical Pharmacology, 15th Edition by Bertram G.
Katzung, Anthony J. Trevor
, Page`2`of`822
Basic`and`Clinical`Pharmacology`15th`Edition`Katzung`Trevor`Test` Bank
Chapter`1.`Introduction:`The`Nature`of`Drugs`&`Drug`Development`&`Regulation
1.
A`nurse`working`in`radiology`administers`iodine`to`a`patient`who`is`having`
a`computed`tomography`(CT)`scan.`The`nurse`working`on`the`oncology`unit`a
dministers`chemotherapy`to`patients`who`have`cancer.`At`the`Public`Health`D
epartment,`a`nurse`administers`a`measles-mumps-
rubella`(MMR)`vaccine`to`a`14-month-
old`child`as`a`routine`immunization.`Which`branch`of`pharmacology`best`desc
ribes`the`actions`of`all`three` nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology`is`the`study`of`the`biologic`effects`of`chemicals.`Nurses`are`inv
olved`with`clinical`pharmacology`or`pharmacotherapeutics,`which`is`a`branch
`of`pharmacology`that`deals`with`the`uses`of`drugs`to`treat,`prevent,`and`diagn
ose`disease.`The`radiology`nurse`is`administering`a`drug`to`help`diagnose`a`di
sease.`The`oncology`nurse`is`administering`a`drug`to`help`treat`a`disease.`Phar
macoeconomics`includes`any`costs`involved`in`drug`therapy.
Pharmacodynamics`involves`how`a`drug`affects`the`body`and`pharmacokinetic
s`is`how`the`body`acts`on`the`body.
2.
When`involved`in`phase`III`drug`evaluation`studies,`what`responsibiliti
es`would`the`nurse`have?
A) Working`with`animals`who`are`given`experimental` drugs
B) Choosing`appropriate`patients`to`be`involved`in`the`drug` study
www.stuvia.com
, Page`3`of`822
C) Monitoring`and`observing`patients`closely`for`adverse` effects
D) Conducting`research`to`determine`effectiveness`of`the` drug
Ans: C
Feedback:
Phase`III`studies`involve`use`of`a`drug`in`a`vast`clinical`population`in`which`p
atients`are`asked`to`record`any`symptoms`they`experience`while`taking`the`dr
ugs.`Nurses`may`be`responsible`for`helping`collect`and`analyze`the`informati
on`to`be`shared`with`the`Food`and`Drug`Administration`(FDA)`but`would`not`
conduct`research`independently`because`nurses`do`not`prescribe`medications.
`Use`of`animals`in`drug`testing`is`done`in`the`preclinical`trials.`Select`patients`
who`are`involved`in`phase`II`studies`to`participate`in`studies`where`the`partici
pants`have`the`disease`the`drug`is`intended`to`treat.`These`patients`are`monito
red`closely`for`drug`action`and`adverse`effects.`Phase`I`studies`involve`health
y`human`volunteers`who`are`usually`paid`for`their`participation.`Nurses`may`
observe`for`adverse`effects`and`toxicity.
3.
A`physician`has`ordered`intramuscular`(IM)`injections`of`morphine,`a`narc
otic,`every`4`hours`as`needed`for`pain`in`a`motor`vehicle`accident`victim.`The`
nurse`is`aware`this`drug`has`a`high`abuse`potential.`Under`what`category`wou
ld`morphine`be`classified?
A) Schedule`I
B) Schedule`II
C) Schedule`III
D) Schedule`IV
Ans: B
Feedback:
Narcotics`with`a`high`abuse`potential`are`classified`as`Schedule`II`drugs`beca
use`of`severe`dependence`liability.`Schedule`I`drugs`have`high`abuse`potenti
al`and`no`accepted`medical`use.`Schedule`III`drugs`have`a`lesser`abuse`poten
tial`than`II`and`an`accepted`medical`use.`Schedule`IV`drugs`have`low`abuse`p
otential`and`limited`dependence`liability.
www.stuvia.com
, Page`4`of`822
4.
What`concept`is`considered`when`generic`drugs`are`substituted`for`bra
nd`name`drugs?
A) Bioavailability
B) Critical`concentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability`is`the`portion`of`a`dose`of`a`drug`that`reaches`the`systemic`cir
culation`and`is`available`to`act`on`body`cells.`Binders`used`in`a`generic`drug`
may`not`be`the`same`as`those`used`in`the`brand`name`drug.`Therefore,`the`wa
y`the`body`breaks`down`and`uses`the`drug`may`differ,`which`may`eliminate`a
`generic`drug`substitution.`Critical`concentration`is`the`amount`of`a`drug`that`
is`needed`to`cause`a`therapeutic`effect`and`should`not`differ`between`generic`
and`brand`name`medications.`Distribution`is`the`phase`of`pharmacokinetics,`
which`involves`the`movement`of`a`drug`to`the`bodys`tissues`and`is`the`same`i
n`generic`and`brand`name`drugs.`A`drugs`half-
life`is`the`time`it`takes`for`the`amount`of`drug`to`decrease`to`half`the`peak`lev
el,`which`should`not`change`when`substituting`a`generic` medication.
5.
A`nurse`is`assessing`the`patients`home`medication`use.`After`listening`to`t
he`patient`list`current`medications,`the`nurse`asks`what`priority`question?
A) Do`you`take`any`generic`medications?
B) Are`any`of`these`medications`orphan` drugs?
C) Are`these`medications`safe`to`take`during` pregnancy?
D) Do`you`take`any`over-the-counter` medications?
Ans: D
Feedback:
www.stuvia.com
