Test Bank for Neonatal and Pediatric Respiratory
Care, 6th Edition
by Brian K. Walsh
,Chapter 1: Fetal Lung Developmen
B B B B
tTest Bank
B B
MULTIPLEBCHOICE
1. WhichBofBtheBfollowingBphasesBofBhumanBlungBdevelopmentBisBcharacterizedBbyBtheBformatio
nBofBaBcapillaryBnetworkBaroundBairwayBpassages?
a. Pseudoglandular
b. Saccular
c. Alveolar
d. Canalicular
ANS:B D
TheBcanalicularBphaseBfollowsBtheBpseudoglandularBphase,BlastingBfromBapproximatelyB17Bwe
eksBtoB26BweeksBofBgestation.BThisBphaseBisBsoBnamedBbecauseBofBtheBappearanceBofBvascularBch
annels,BorBcapillaries,BwhichBbeginBtoBgrowBbyBformingBaBcapillaryBnetworkBaroundBtheBairBpa
ssages.BDuringBtheBpseudoglandularBstage,BwhichBbeginsBatBdayB52BandBextendsBtoBweekB16Bo
fBgestation,BtheBairwayBsystemBsubdividesBextensivelyBandBtheBconductingBairwayBsystemBdev
elops,BendingBwithBtheBterminalBbronchioles.BTheBsaccularBstageBofBdevelopment,BwhichBtakes
BplaceBfromBweeksB29BtoB36BofBgestation,BisBcharacterizedBbyBtheBdevelopmentBofBsacsBthatB late
rBbecomeBalveoli.BDuringBtheBsaccularBphase,BaBtremendousBincreaseBinBtheBpotential
gas-
exchangingBsurfaceBareaBoccurs.BTheBdistinctionBbetweenBtheBsaccularBstageBandBtheBalve
olarBstageBisBarbitrary.BTheBalveolarBstageBstretchesBfromB39BweeksBofBgestationBtoBterm.B
ThisBstageBisBrepresentedBbyBtheBestablishmentBofBalveoli.
REF:B pp.BBB 3-5
2. RegardingBpostnatalBlungBgrowth,BbyBapproximatelyBwhatBageBdoBmostBofBtheBalveoliBthatB
willBbeBpresentBinBtheBlungsBforBlifeBdevelop?
a. 6Bmonths
b. 1Byear
c. 1.5Byears
d. 2Byears
ANS:B C
MostBofBtheBpostnatalBformationBofBalveoliBinBtheBinfantBoccursBoverBtheBfirstB1.5ByearsBofBlife
.BAtB2ByearsBofBage,BtheBnumberBofBalveoliBvariesBsubstantiallyBamongBindividuals.BAfterB2Bye
arsBofBage,BmalesBhaveBmoreBalveoliBthanBdoBfemales.BAfterBalveolarBmultiplicationBends,BtheBa
lveoliBcontinueBtoBincreaseBinBsizeBuntilBthoracicBgrowthBisBcompleted.
REF:B p.B6
3. TheBrespiratoryBtherapistBisBevaluatingBaBnewbornBwithBmildBrespiratoryBdistressBdueBtoBtrac
healBstenosis.BDuringBwhichBperiodBofBlungBdevelopmentBdidBthisBproblemBdevelop?
a. Embryonal
b. Saccular
c. Canalicular
d. Alveolar
ANS:B A
, TheBinitialBstructuresBofBtheBpulmonaryBtreeBdevelopBduringBtheBembryonalBstage.BErrorsBin
BdevelopmentBduringBthisBtimeBmayBresultBinBlaryngeal,Btracheal,BorBesophagealBatresiaBorBst
enosis.BPulmonaryBhypoplasia,BanBincompleteBdevelopmentBofBtheBlungsBcharacterizedBbyBanB
abnormallyBlowBnumberBand/orBsizeBofBbronchopulmonaryBsegmentsBand/orBalveoli,BcanBde
velopBduringBtheBpseudoglandularBphase.BIfBtheBfetusBisBbornBduringBtheBcanalicularBphaseB(i.
e.,Bprematurely),BsevereBrespiratoryBdistressBcanBbeBexpectedBbecauseBtheBinadequatelyBdevel
opedBairways,BalongBwithBinsufficientBandBimmatureBsurfactantBproductionBbyBalveolarBtypeB
IIBcells,BgivesBriseBtoBtheBconstellationBofBproblemsBknownBasBinfantBrespiratoryBdistressBsyndro
me.
REF:BBB p.B6
4. WhichBofBtheBfollowingBmechanismsBisB(are)BresponsibleBforBtheBpossibleBassociationBbetwee
nBoligohydramniosBandBlungBhypoplasia?
I. AbnormalBcarbohydrateBmetabolism
II. MechanicalBrestrictionBofBtheBchestBwall
III. InterferenceBwithBfetalBbreathing
IV. FailureBtoBproduceBfetalBlungBliquid
a. IBandBIIIBonly
b. IIBandBIIIBonly
c. I,BII,BandBIVBonly
d. II,BIII,BandBIVBonly
ANS:B D
Oligohydramnios,BaBreducedBquantityBofBamnioticBfluidBpresentBforBanBextendedBperiodBofBtime,
withBorBwithoutBrenalBanomTaE lieSsT
,BiB
sBA
asNsoKcS
iaE
teLdLwEitR
hBlu
. CnO
gBM
hypoplasia.BTheBmechanismsBbyBB
whichBamnioticBfluidBvolumeBinfluencesBlungBgrowthBremainBunclear.BPossibleBexplanationsBf
or
reducedBquantityBofBamnioticBfluidBincludeBmechanicalBrestrictionBofBtheBchestBwall,Binterfer
enceBwithBfetalBbreathing,BorBfailureBtoBproduceBfetalBlungBliquid.BTheseBclinicalBandBexperi
mentalBobservationsBpossiblyBpointBtoBaBcommonBdenominator,BlungBstretch,BasBbeingBaBmaj
orBgrowthBstimulant.
REF:B pp.B6-7
5. WhatBisBtheBpurposeBofBtheBsubstanceBsecretedBbyBtheBtypeBIIBpneumocyte?
a. ToBincreaseBtheBgasBexchangeBsurfaceBarea
b. ToBreduceBsurfaceBtension
c. ToBmaintainBlungBelasticity
d. ToBpreserveBtheBvolumeBofBtheBamnioticBfluid
ANS:B B
TheBprimaryBroleBofBmammalianBsurfactantBisBtoBlowerBtheBsurfaceBtensionBwithinBtheBalveolu
s,BspecificallyBatBtheBair–
liquidBinterface.BThisBallowsBtheBdelicateBstructureBofBtheBalveolusBtoBexpandBwhenBfilledBwith
Bair.BWithoutBsurfactant,BtheBalveolusBremainsBcollapsedBbecauseBofBtheB highBsurfaceBtensionBof
BtheBmoistBalveolarBsurface.B SurfactantBisBcomposedBpredominantlyBofBanBintricateBblendBofBph
ospholipids,BneutralBlipids,BandBproteins.
REF:B p.B8
, 6. WhichBofBtheBfollowingBtestsBofBtheBamnioticBfluidBhaveBbeenBshownBtoBbeBsensitiveBindicato
rsBofBlungBmaturity?
a. LevelsBofBprednisone
b. LevelsBofBepidermalBgrowthBfactor
c. LevelsBofBprostaglandins
d. LevelsBofBphosphatidylglycerolBandBphosphatidylcholine
ANS:B D
OfBclinicalBrelevanceBduringBlateBgestation,BanalysisBofBamnioticBfluidBforBtheBconcentrationB
ofBphosphatidylglycerolBandBphosphatidylcholineBhasBbeenBshownBtoBbeBaBsensitiveBindicator
BofBtheBstateBofBfetalBlungBmaturity.
REF:B p.B8
7.BApproximatelyBhowBmuchBfetalBlungBfluidBisBsecretedBdaily?
a.BAboutB150BtoB200Bml
b.BAboutB250BtoB300Bml
c.BAboutB350BtoB400Bml
d.BAboutB450BtoB500Bml
ANS:BB
FetalBlungsBareBsecretoryBorgansBthatBmakeBbreathing-
likeBmovementsBbutBserveBnoBrespiratoryBfunctionBbeforeBbirth.BTheyBsecreteB
aboutB250BtoB300BmlBofBliquidBperBday.
B8.BTheBlungBbudBemergesBfromBwhichBofBtheBfollowingBstructures?
a.BTheBpharynx
b.BTheBforegut
c.BTheBmesenchyme
d.BTheBtubularBepithelium
ANS:BA
TheBembryonalBphaseBincludesBprimitiveBlungBdevelopmentBandBisBgenerallyBregardedBtoBencompassBtheBfirstB2Bm
onthsBofBgestation.B
TheBlungBbeginsBtoBemergeBasBaBbudBfromBtheBpharynxB26BdaysBafterBconception.
Care, 6th Edition
by Brian K. Walsh
,Chapter 1: Fetal Lung Developmen
B B B B
tTest Bank
B B
MULTIPLEBCHOICE
1. WhichBofBtheBfollowingBphasesBofBhumanBlungBdevelopmentBisBcharacterizedBbyBtheBformatio
nBofBaBcapillaryBnetworkBaroundBairwayBpassages?
a. Pseudoglandular
b. Saccular
c. Alveolar
d. Canalicular
ANS:B D
TheBcanalicularBphaseBfollowsBtheBpseudoglandularBphase,BlastingBfromBapproximatelyB17Bwe
eksBtoB26BweeksBofBgestation.BThisBphaseBisBsoBnamedBbecauseBofBtheBappearanceBofBvascularBch
annels,BorBcapillaries,BwhichBbeginBtoBgrowBbyBformingBaBcapillaryBnetworkBaroundBtheBairBpa
ssages.BDuringBtheBpseudoglandularBstage,BwhichBbeginsBatBdayB52BandBextendsBtoBweekB16Bo
fBgestation,BtheBairwayBsystemBsubdividesBextensivelyBandBtheBconductingBairwayBsystemBdev
elops,BendingBwithBtheBterminalBbronchioles.BTheBsaccularBstageBofBdevelopment,BwhichBtakes
BplaceBfromBweeksB29BtoB36BofBgestation,BisBcharacterizedBbyBtheBdevelopmentBofBsacsBthatB late
rBbecomeBalveoli.BDuringBtheBsaccularBphase,BaBtremendousBincreaseBinBtheBpotential
gas-
exchangingBsurfaceBareaBoccurs.BTheBdistinctionBbetweenBtheBsaccularBstageBandBtheBalve
olarBstageBisBarbitrary.BTheBalveolarBstageBstretchesBfromB39BweeksBofBgestationBtoBterm.B
ThisBstageBisBrepresentedBbyBtheBestablishmentBofBalveoli.
REF:B pp.BBB 3-5
2. RegardingBpostnatalBlungBgrowth,BbyBapproximatelyBwhatBageBdoBmostBofBtheBalveoliBthatB
willBbeBpresentBinBtheBlungsBforBlifeBdevelop?
a. 6Bmonths
b. 1Byear
c. 1.5Byears
d. 2Byears
ANS:B C
MostBofBtheBpostnatalBformationBofBalveoliBinBtheBinfantBoccursBoverBtheBfirstB1.5ByearsBofBlife
.BAtB2ByearsBofBage,BtheBnumberBofBalveoliBvariesBsubstantiallyBamongBindividuals.BAfterB2Bye
arsBofBage,BmalesBhaveBmoreBalveoliBthanBdoBfemales.BAfterBalveolarBmultiplicationBends,BtheBa
lveoliBcontinueBtoBincreaseBinBsizeBuntilBthoracicBgrowthBisBcompleted.
REF:B p.B6
3. TheBrespiratoryBtherapistBisBevaluatingBaBnewbornBwithBmildBrespiratoryBdistressBdueBtoBtrac
healBstenosis.BDuringBwhichBperiodBofBlungBdevelopmentBdidBthisBproblemBdevelop?
a. Embryonal
b. Saccular
c. Canalicular
d. Alveolar
ANS:B A
, TheBinitialBstructuresBofBtheBpulmonaryBtreeBdevelopBduringBtheBembryonalBstage.BErrorsBin
BdevelopmentBduringBthisBtimeBmayBresultBinBlaryngeal,Btracheal,BorBesophagealBatresiaBorBst
enosis.BPulmonaryBhypoplasia,BanBincompleteBdevelopmentBofBtheBlungsBcharacterizedBbyBanB
abnormallyBlowBnumberBand/orBsizeBofBbronchopulmonaryBsegmentsBand/orBalveoli,BcanBde
velopBduringBtheBpseudoglandularBphase.BIfBtheBfetusBisBbornBduringBtheBcanalicularBphaseB(i.
e.,Bprematurely),BsevereBrespiratoryBdistressBcanBbeBexpectedBbecauseBtheBinadequatelyBdevel
opedBairways,BalongBwithBinsufficientBandBimmatureBsurfactantBproductionBbyBalveolarBtypeB
IIBcells,BgivesBriseBtoBtheBconstellationBofBproblemsBknownBasBinfantBrespiratoryBdistressBsyndro
me.
REF:BBB p.B6
4. WhichBofBtheBfollowingBmechanismsBisB(are)BresponsibleBforBtheBpossibleBassociationBbetwee
nBoligohydramniosBandBlungBhypoplasia?
I. AbnormalBcarbohydrateBmetabolism
II. MechanicalBrestrictionBofBtheBchestBwall
III. InterferenceBwithBfetalBbreathing
IV. FailureBtoBproduceBfetalBlungBliquid
a. IBandBIIIBonly
b. IIBandBIIIBonly
c. I,BII,BandBIVBonly
d. II,BIII,BandBIVBonly
ANS:B D
Oligohydramnios,BaBreducedBquantityBofBamnioticBfluidBpresentBforBanBextendedBperiodBofBtime,
withBorBwithoutBrenalBanomTaE lieSsT
,BiB
sBA
asNsoKcS
iaE
teLdLwEitR
hBlu
. CnO
gBM
hypoplasia.BTheBmechanismsBbyBB
whichBamnioticBfluidBvolumeBinfluencesBlungBgrowthBremainBunclear.BPossibleBexplanationsBf
or
reducedBquantityBofBamnioticBfluidBincludeBmechanicalBrestrictionBofBtheBchestBwall,Binterfer
enceBwithBfetalBbreathing,BorBfailureBtoBproduceBfetalBlungBliquid.BTheseBclinicalBandBexperi
mentalBobservationsBpossiblyBpointBtoBaBcommonBdenominator,BlungBstretch,BasBbeingBaBmaj
orBgrowthBstimulant.
REF:B pp.B6-7
5. WhatBisBtheBpurposeBofBtheBsubstanceBsecretedBbyBtheBtypeBIIBpneumocyte?
a. ToBincreaseBtheBgasBexchangeBsurfaceBarea
b. ToBreduceBsurfaceBtension
c. ToBmaintainBlungBelasticity
d. ToBpreserveBtheBvolumeBofBtheBamnioticBfluid
ANS:B B
TheBprimaryBroleBofBmammalianBsurfactantBisBtoBlowerBtheBsurfaceBtensionBwithinBtheBalveolu
s,BspecificallyBatBtheBair–
liquidBinterface.BThisBallowsBtheBdelicateBstructureBofBtheBalveolusBtoBexpandBwhenBfilledBwith
Bair.BWithoutBsurfactant,BtheBalveolusBremainsBcollapsedBbecauseBofBtheB highBsurfaceBtensionBof
BtheBmoistBalveolarBsurface.B SurfactantBisBcomposedBpredominantlyBofBanBintricateBblendBofBph
ospholipids,BneutralBlipids,BandBproteins.
REF:B p.B8
, 6. WhichBofBtheBfollowingBtestsBofBtheBamnioticBfluidBhaveBbeenBshownBtoBbeBsensitiveBindicato
rsBofBlungBmaturity?
a. LevelsBofBprednisone
b. LevelsBofBepidermalBgrowthBfactor
c. LevelsBofBprostaglandins
d. LevelsBofBphosphatidylglycerolBandBphosphatidylcholine
ANS:B D
OfBclinicalBrelevanceBduringBlateBgestation,BanalysisBofBamnioticBfluidBforBtheBconcentrationB
ofBphosphatidylglycerolBandBphosphatidylcholineBhasBbeenBshownBtoBbeBaBsensitiveBindicator
BofBtheBstateBofBfetalBlungBmaturity.
REF:B p.B8
7.BApproximatelyBhowBmuchBfetalBlungBfluidBisBsecretedBdaily?
a.BAboutB150BtoB200Bml
b.BAboutB250BtoB300Bml
c.BAboutB350BtoB400Bml
d.BAboutB450BtoB500Bml
ANS:BB
FetalBlungsBareBsecretoryBorgansBthatBmakeBbreathing-
likeBmovementsBbutBserveBnoBrespiratoryBfunctionBbeforeBbirth.BTheyBsecreteB
aboutB250BtoB300BmlBofBliquidBperBday.
B8.BTheBlungBbudBemergesBfromBwhichBofBtheBfollowingBstructures?
a.BTheBpharynx
b.BTheBforegut
c.BTheBmesenchyme
d.BTheBtubularBepithelium
ANS:BA
TheBembryonalBphaseBincludesBprimitiveBlungBdevelopmentBandBisBgenerallyBregardedBtoBencompassBtheBfirstB2Bm
onthsBofBgestation.B
TheBlungBbeginsBtoBemergeBasBaBbudBfromBtheBpharynxB26BdaysBafterBconception.