©THESTAR 2024/2025 ALL RIGHTS RESERVED 11:04PM.
MSN 671 NEI Global Video Questions And
Answers 2025 Update.
Communication between human CNS neurons at synapses is: - Answer✔Chemical
An example of volume neurotransmission is: - Answer✔Dopamine in the prefrontal cortex
The direct role of transcription factors is to: - Answer✔Influence gene expression
The term epigenetics refers to: - Answer✔A process determining whether a given gene is
expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - Answer✔Serotonin and GABA
What is constitutive activity? - Answer✔Signal transduction when no agonist or inverse agonist
is bound to the receptor.
A partial agonist has what effect on neurotransmission? - Answer✔Net agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - Answer✔Open more frequently
Which of the following is true? - Answer✔Both positive and negative allosteric modulations are
possible only in the presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is: -
Answer✔Into the neuron
Which of the following are involved in regulating neurotransmission via excitation-secretion
coupling? - Answer✔Both of these which are voltage-sensitive sodium channels and voltage-
sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his parents.
He speaks with a reserved and simple language processing style; he is able to understand and
1
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 11:04PM.
relate to simple questions but seems to get lost when the pace of the conversation between
the clinician and parents accelerates. when reviewing the patient's history, what pattern of
cognitive functioning prior to psychosis onset would you be most likely to find? -
Answer✔Impaired cognitive functioning premorbidly with further decline during the prodromal
phase.
Dopamine (DA) receptors can be categorized as D1 like (D1 and D5 receptors) and D2 like (D2,
D3, and D4 receptors). What differentiates the two groups of receptors? - Answer✔D1-like
receptors are excitatory and D2-like receptors are inhibitory.
Symptoms of schizophrenia are hypothetically attributable to malfucntioning in the: -
Answer✔Mesocortical and mesolimbic pathways
For which set of disorders is psychosis considered an associated feature rather than a defining
feature for diagnosis? - Answer✔Bipolar mania, Parkinson's disease.
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of: -
Answer✔Glutamate and glycine.
A leading hypothesis of psychosis is: - Answer✔Hypofunctioning NMDA receptors.
Dysfunction of NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to lead to
what effects on dopamine (DA)? - Answer✔Excessive DA release in the NA and reduced DA
release in the PFC.
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea that
aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - Answer✔Rarely used synapses are pruned, while frequently used
synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of psychosis? -
Answer✔Serotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
Answer✔5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
Answer✔Acetylcholine, norepinephrine, and serotonin.
Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
Answer✔5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead to: -
Answer✔Improvement in positive symptoms of psychosis and development of secondary
negative symptoms.
2
MSN 671 NEI Global Video Questions And
Answers 2025 Update.
Communication between human CNS neurons at synapses is: - Answer✔Chemical
An example of volume neurotransmission is: - Answer✔Dopamine in the prefrontal cortex
The direct role of transcription factors is to: - Answer✔Influence gene expression
The term epigenetics refers to: - Answer✔A process determining whether a given gene is
expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - Answer✔Serotonin and GABA
What is constitutive activity? - Answer✔Signal transduction when no agonist or inverse agonist
is bound to the receptor.
A partial agonist has what effect on neurotransmission? - Answer✔Net agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - Answer✔Open more frequently
Which of the following is true? - Answer✔Both positive and negative allosteric modulations are
possible only in the presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is: -
Answer✔Into the neuron
Which of the following are involved in regulating neurotransmission via excitation-secretion
coupling? - Answer✔Both of these which are voltage-sensitive sodium channels and voltage-
sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his parents.
He speaks with a reserved and simple language processing style; he is able to understand and
1
, ©THESTAR 2024/2025 ALL RIGHTS RESERVED 11:04PM.
relate to simple questions but seems to get lost when the pace of the conversation between
the clinician and parents accelerates. when reviewing the patient's history, what pattern of
cognitive functioning prior to psychosis onset would you be most likely to find? -
Answer✔Impaired cognitive functioning premorbidly with further decline during the prodromal
phase.
Dopamine (DA) receptors can be categorized as D1 like (D1 and D5 receptors) and D2 like (D2,
D3, and D4 receptors). What differentiates the two groups of receptors? - Answer✔D1-like
receptors are excitatory and D2-like receptors are inhibitory.
Symptoms of schizophrenia are hypothetically attributable to malfucntioning in the: -
Answer✔Mesocortical and mesolimbic pathways
For which set of disorders is psychosis considered an associated feature rather than a defining
feature for diagnosis? - Answer✔Bipolar mania, Parkinson's disease.
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of: -
Answer✔Glutamate and glycine.
A leading hypothesis of psychosis is: - Answer✔Hypofunctioning NMDA receptors.
Dysfunction of NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to lead to
what effects on dopamine (DA)? - Answer✔Excessive DA release in the NA and reduced DA
release in the PFC.
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea that
aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - Answer✔Rarely used synapses are pruned, while frequently used
synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of psychosis? -
Answer✔Serotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
Answer✔5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
Answer✔Acetylcholine, norepinephrine, and serotonin.
Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
Answer✔5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead to: -
Answer✔Improvement in positive symptoms of psychosis and development of secondary
negative symptoms.
2
