NR565 / NR 565 Advanced Pharmacology
Fundamentals Final Exam Question Bank (Latest
): - Chamberlain
Terms in this set (287)
The process by which drugs are absorbed, distributed
Pharmacokinetics
within the body, metabolized, and excreted.
Pharmacodynamics The study of what the drug does to the body
Rate of dissolution
Surface area
Factors Affecting Drug
Blood flow
Absorption
Lipid solubility
pH partitioning
Blood flow to tissues
Factors Affecting Drug Ability to exit the vascular system
Distribution Blood-brain barrier
Protein-binding capacity
substances that are foreign to the body, usually
Xenobiotics synthetic chemical compounds; medications are a
common example
xenobiotic-metabolizing enzymes necessary for the
Cytochrome P450
production of cholesterol and steroids and the
(CYP450)
detoxification of chemicals and drug metabolism.
Function of Cytochrome responsible for phase 1 metabolism in which drugs are
P450 (CYP450) oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Oxidation; Reduction; Hydrolysis
Drugs via P450
, -Drug becomes completely inactive
Three possible outcomes -Drug becomes partially inactive but one or more
of phase 1 drug metabolites remain active
metabolism.
-Original drug is not pharmacologically active but
one metabolite remains active
Medications that can increase the rate of another
drug's metabolism by elevating CYP450 enzyme
CYP450 Inducers
activity via increasing enzyme synthesis. decreasing
the concentration of the "parent drug"
CRAPGPS
Carbamazepine
Rifampin
CYP450 Inducer Alcohol
Medications Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
Medications that inhibit the metabolic activity of one
or more of the CYP450 enzymes. Higher risk for
CYP450 Inhibitors
toxicity; prolongs the pharmacological effect of the
"parent drug".
VISACKGQ
Valproate
Isoniazid
Sulfonamides
CYP450 Inhibitor
Amiodarone
Medications
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
Fundamentals Final Exam Question Bank (Latest
): - Chamberlain
Terms in this set (287)
The process by which drugs are absorbed, distributed
Pharmacokinetics
within the body, metabolized, and excreted.
Pharmacodynamics The study of what the drug does to the body
Rate of dissolution
Surface area
Factors Affecting Drug
Blood flow
Absorption
Lipid solubility
pH partitioning
Blood flow to tissues
Factors Affecting Drug Ability to exit the vascular system
Distribution Blood-brain barrier
Protein-binding capacity
substances that are foreign to the body, usually
Xenobiotics synthetic chemical compounds; medications are a
common example
xenobiotic-metabolizing enzymes necessary for the
Cytochrome P450
production of cholesterol and steroids and the
(CYP450)
detoxification of chemicals and drug metabolism.
Function of Cytochrome responsible for phase 1 metabolism in which drugs are
P450 (CYP450) oxidized, reduced, or hydrolyzed
Phase 1 Metabolism of Oxidation; Reduction; Hydrolysis
Drugs via P450
, -Drug becomes completely inactive
Three possible outcomes -Drug becomes partially inactive but one or more
of phase 1 drug metabolites remain active
metabolism.
-Original drug is not pharmacologically active but
one metabolite remains active
Medications that can increase the rate of another
drug's metabolism by elevating CYP450 enzyme
CYP450 Inducers
activity via increasing enzyme synthesis. decreasing
the concentration of the "parent drug"
CRAPGPS
Carbamazepine
Rifampin
CYP450 Inducer Alcohol
Medications Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas
Medications that inhibit the metabolic activity of one
or more of the CYP450 enzymes. Higher risk for
CYP450 Inhibitors
toxicity; prolongs the pharmacological effect of the
"parent drug".
VISACKGQ
Valproate
Isoniazid
Sulfonamides
CYP450 Inhibitor
Amiodarone
Medications
Chloramphenicol
Ketoconazole
Grapefruit Juice
Quinidine
