MSN 671 NEI Global Video Exam
Questions and answers 2025
Communication .between .human .CNS .neurons .at .synapses .is: .- .ANS✓✓-
Chemical
An .example .of .volume .neurotransmission .is: .- .ANS✓✓-Dopamine .in .the
.prefrontal .cortex
The .direct .role .of .transcription .factors .is .to: .- .ANS✓✓-Influence .gene
.expression
The .term .epigenetics .refers .to: .- .ANS✓✓-A .process .determining .whether .a
.given .gene .is .expressed .or .silenced
Presynaptic .reuptake .transporters .are .a .major .method .of .inactivation .for .which
.of .the .following? .- .ANS✓✓-Serotonin .and .GABA
What .is .constitutive .activity? .- .ANS✓✓-Signal .transduction .when .no .agonist .or
.inverse .agonist .is .bound .to .the .receptor.
A .partial .agonist .has .what .effect .on .neurotransmission? .- .ANS✓✓-Net .agonism
.when .neurotransmission .is .deficient. .
Net .antagonism .when .neurotransmission .is .excessive. .
Both .of .the .above .answers .are .correct
Agonists .cause .ligand-gated .ion .channels .to: .- .ANS✓✓-Open .more .frequently
, Which .of .the .following .is .true? .- .ANS✓✓-Both .positive .and .negative .allosteric
.modulations .are .possible .only .in .the .presence .of .a .neurotransmitter
When .voltage-sensitive .sodium .channels .are .open .and .activated, .the .flow .of
.sodium .is: .- .ANS✓✓-Into .the .neuron
Which .of .the .following .are .involved .in .regulating .neurotransmission .via
.excitation-secretion .coupling? .- .ANS✓✓-Both .of .these .which .are .voltage-
sensitive .sodium .channels .and .voltage-sensitive .calcium .channels.
A .21-year-old .man .who .has .just .been .diagnosed .with .schizophrenia .presents
.with .his .parents. .He .speaks .with .a .reserved .and .simple .language .processing
.style; .he .is .able .to .understand .and .relate .to .simple .questions .but .seems .to .get
.lost .when .the .pace .of .the .conversation .between .the .clinician .and .parents
.accelerates. .when .reviewing .the .patient's .history, .what .pattern .of .cognitive
.functioning .prior .to .psychosis .onset .would .you .be .most .likely .to .find? .- .ANS✓
✓-Impaired .cognitive .functioning .premorbidly .with .further .decline .during .the
.prodromal .phase.
Dopamine .(DA) .receptors .can .be .categorized .as .D1 .like .(D1 .and .D5 .receptors)
.and .D2 .like .(D2, .D3, .and .D4 .receptors). .What .differentiates .the .two .groups .of
.receptors? .- .ANS✓✓-D1-like .receptors .are .excitatory .and .D2-like .receptors .are
.inhibitory.
Symptoms .of .schizophrenia .are .hypothetically .attributable .to .malfucntioning .in
.the: .- .ANS✓✓-Mesocortical .and .mesolimbic .pathways
For .which .set .of .disorders .is .psychosis .considered .an .associated .feature
.rather .than .a .defining .feature .for .diagnosis? .- .ANS✓✓-Bipolar .mania,
.Parkinson's .disease.
The .activation .of .N-methyl-d-aspartate .(NMDA) .receptors .requires .the .presence
.of: .- .ANS✓✓-Glutamate .and .glycine.
A .leading .hypothesis .of .psychosis .is: .- .ANS✓✓-Hypofunctioning .NMDA
.receptors.
Questions and answers 2025
Communication .between .human .CNS .neurons .at .synapses .is: .- .ANS✓✓-
Chemical
An .example .of .volume .neurotransmission .is: .- .ANS✓✓-Dopamine .in .the
.prefrontal .cortex
The .direct .role .of .transcription .factors .is .to: .- .ANS✓✓-Influence .gene
.expression
The .term .epigenetics .refers .to: .- .ANS✓✓-A .process .determining .whether .a
.given .gene .is .expressed .or .silenced
Presynaptic .reuptake .transporters .are .a .major .method .of .inactivation .for .which
.of .the .following? .- .ANS✓✓-Serotonin .and .GABA
What .is .constitutive .activity? .- .ANS✓✓-Signal .transduction .when .no .agonist .or
.inverse .agonist .is .bound .to .the .receptor.
A .partial .agonist .has .what .effect .on .neurotransmission? .- .ANS✓✓-Net .agonism
.when .neurotransmission .is .deficient. .
Net .antagonism .when .neurotransmission .is .excessive. .
Both .of .the .above .answers .are .correct
Agonists .cause .ligand-gated .ion .channels .to: .- .ANS✓✓-Open .more .frequently
, Which .of .the .following .is .true? .- .ANS✓✓-Both .positive .and .negative .allosteric
.modulations .are .possible .only .in .the .presence .of .a .neurotransmitter
When .voltage-sensitive .sodium .channels .are .open .and .activated, .the .flow .of
.sodium .is: .- .ANS✓✓-Into .the .neuron
Which .of .the .following .are .involved .in .regulating .neurotransmission .via
.excitation-secretion .coupling? .- .ANS✓✓-Both .of .these .which .are .voltage-
sensitive .sodium .channels .and .voltage-sensitive .calcium .channels.
A .21-year-old .man .who .has .just .been .diagnosed .with .schizophrenia .presents
.with .his .parents. .He .speaks .with .a .reserved .and .simple .language .processing
.style; .he .is .able .to .understand .and .relate .to .simple .questions .but .seems .to .get
.lost .when .the .pace .of .the .conversation .between .the .clinician .and .parents
.accelerates. .when .reviewing .the .patient's .history, .what .pattern .of .cognitive
.functioning .prior .to .psychosis .onset .would .you .be .most .likely .to .find? .- .ANS✓
✓-Impaired .cognitive .functioning .premorbidly .with .further .decline .during .the
.prodromal .phase.
Dopamine .(DA) .receptors .can .be .categorized .as .D1 .like .(D1 .and .D5 .receptors)
.and .D2 .like .(D2, .D3, .and .D4 .receptors). .What .differentiates .the .two .groups .of
.receptors? .- .ANS✓✓-D1-like .receptors .are .excitatory .and .D2-like .receptors .are
.inhibitory.
Symptoms .of .schizophrenia .are .hypothetically .attributable .to .malfucntioning .in
.the: .- .ANS✓✓-Mesocortical .and .mesolimbic .pathways
For .which .set .of .disorders .is .psychosis .considered .an .associated .feature
.rather .than .a .defining .feature .for .diagnosis? .- .ANS✓✓-Bipolar .mania,
.Parkinson's .disease.
The .activation .of .N-methyl-d-aspartate .(NMDA) .receptors .requires .the .presence
.of: .- .ANS✓✓-Glutamate .and .glycine.
A .leading .hypothesis .of .psychosis .is: .- .ANS✓✓-Hypofunctioning .NMDA
.receptors.
