NUR 210 exam 1 material Pharmacology
Principles
drug response - Answer-the intensity of the drug response is directly related to the concentration of the
drug at the SITE OF ACTION
Goal is to:
- maximize the beneficial effects- concentration high enough for desired response
- minimize harm- avoid to high a concentration
Three phases of drug action - Answer-1. pharmaceutic phase (dissolution)
2. pharmacokinetic phase (drug moving through the body)
3. pharmacodynamic phase (what the drug does to the body)
1. pharmaceutic phase - Answer-the drug goes into solution
- Dissolution: the process by which a drug goes into solution and becomes available for absorption
- must be dissolved before it can be absorbed
- most absorption takes place in the small intestine
,2. pharmacokinetic phase: four processes - Answer-"what the BODY does to the drug"
- absorption
- distribution
- metabolism/ biotransformation
- exertion
pharmacokinetic phase: Absorption - Answer-(small intestine) the movement of a drug from its site of
administration into the blood
pharmacokinetic phase: Distribution - Answer-drug moves from blood --> cell membrane
pharmacokinetic phase: Metabolism/biotransformation - Answer-lipid soluble metabolite (liver) --> a
water soluble metabolite
pharmacokinetic phase: Excretion - Answer-water soluble metabolite (kidneys)
liver - Answer-breaks down the drug
kidneys - Answer-excretes the drug
Pharmacokinetic phase movement process - Answer-orally --> stomach --> SI --> bloodstream --> site of
action --> liver (broken down) --> kidneys (excreted)
IV --> bloodstream --> cite of action --> liver --> kidneys
drugs crossing the cell membranes phospholipid cell layer - Answer--drugs must be LIPID SOLUBLE in
order to pass through the membrane
, - WATER SOLUBLE drugs penetrate the cell membrane through channels and pores
Absorption
1. direct penetration of the membranes
2. channels and pores
3. transport systems - Answer-the movement of a drug from its site of administration to the blood
How do drugs cross membranes?
1. Direct penetration of the membranes - Answer-- use by MOST drugs
- most drugs to large to pass thru channels and pores
- most drugs lack transport systems
- drugs must be lipid soluble to be able to penetrate cellular membranes = lipophilic drugs
2. channels and pores - Answer-only very small ions such as potassium and sodium can pass through cell
membranes
3. transport systems - Answer-- are carriers that can move drugs from one side of the membrane to the
other
- are selective
Movement of drugs across membranes - Answer--drugs must cross membranes (pass through cells) to
enter the blood from their site of administration
- drugs must then leave the blood (vascular systems) to get to their SITE OF ACTION
Principles
drug response - Answer-the intensity of the drug response is directly related to the concentration of the
drug at the SITE OF ACTION
Goal is to:
- maximize the beneficial effects- concentration high enough for desired response
- minimize harm- avoid to high a concentration
Three phases of drug action - Answer-1. pharmaceutic phase (dissolution)
2. pharmacokinetic phase (drug moving through the body)
3. pharmacodynamic phase (what the drug does to the body)
1. pharmaceutic phase - Answer-the drug goes into solution
- Dissolution: the process by which a drug goes into solution and becomes available for absorption
- must be dissolved before it can be absorbed
- most absorption takes place in the small intestine
,2. pharmacokinetic phase: four processes - Answer-"what the BODY does to the drug"
- absorption
- distribution
- metabolism/ biotransformation
- exertion
pharmacokinetic phase: Absorption - Answer-(small intestine) the movement of a drug from its site of
administration into the blood
pharmacokinetic phase: Distribution - Answer-drug moves from blood --> cell membrane
pharmacokinetic phase: Metabolism/biotransformation - Answer-lipid soluble metabolite (liver) --> a
water soluble metabolite
pharmacokinetic phase: Excretion - Answer-water soluble metabolite (kidneys)
liver - Answer-breaks down the drug
kidneys - Answer-excretes the drug
Pharmacokinetic phase movement process - Answer-orally --> stomach --> SI --> bloodstream --> site of
action --> liver (broken down) --> kidneys (excreted)
IV --> bloodstream --> cite of action --> liver --> kidneys
drugs crossing the cell membranes phospholipid cell layer - Answer--drugs must be LIPID SOLUBLE in
order to pass through the membrane
, - WATER SOLUBLE drugs penetrate the cell membrane through channels and pores
Absorption
1. direct penetration of the membranes
2. channels and pores
3. transport systems - Answer-the movement of a drug from its site of administration to the blood
How do drugs cross membranes?
1. Direct penetration of the membranes - Answer-- use by MOST drugs
- most drugs to large to pass thru channels and pores
- most drugs lack transport systems
- drugs must be lipid soluble to be able to penetrate cellular membranes = lipophilic drugs
2. channels and pores - Answer-only very small ions such as potassium and sodium can pass through cell
membranes
3. transport systems - Answer-- are carriers that can move drugs from one side of the membrane to the
other
- are selective
Movement of drugs across membranes - Answer--drugs must cross membranes (pass through cells) to
enter the blood from their site of administration
- drugs must then leave the blood (vascular systems) to get to their SITE OF ACTION
