NU 578 Unit 1 Adrenergic
Agonists Drugs
What does the autonomic system control?
smooth and cardiac muscles and glandular secretion
What does the sympathetic system do to the body
Increases HR, dilates pupils, dilates bronchi, decreases secretions, and expands
energy, "fight or flight"
Book states:
-Regulating the cardiovascular system
-Regulating body temperature
- Implementing the acute stress response (commonly called a "fight-or-flight"
reaction)
What does the parasympathetic system do to the body
Dominates at rest, Conserves energy, decreases HR, increases GI tract functions,
constricts pupils
What processes are happening for neurotransmission to occur
,Synthesis of neurotransmitters (NTs)
• Packaging of NTs in presynaptic terminals
• Stimulation of presynaptic nerve/release of NT
• Diffusion of NT across synaptic cleft & and binding to post-synaptic membrane
• Activation of the postsynaptic cell
• Degradation/reuptake of the NT
What are specific neurotransmitters in the body
Norepinephrine (NE)
• Epinephrine (Epi)
• Dopamine (DA)
• Acetylcholine (Ach)
• Also, 5-HT (Serotonin), and gamma-aminobutyric acid (GABA)
Activation of alpha 1 receptors causes.....
-Vasoconstriction
-↓secretions
-pupil dilation
-↓GI motility
-urinary retention
, Activation of alpha 2 receptors causes
-↓CNS sympathetic outflow(postsynaptic),
-↓NE release (presynaptic),
-↓insulin release
Name DIRECT acting sympathetic agonists
Epinephrine, Norepinephrine, dopamine, dobutamine, phenylephrine, Terbutaline,
Mirabegron
Activation of Beta 1 receptors causes...
↑HR,
↑CO,
↑automaticity,
↑contractility,
↑renin secretion
Activation of Beta 2 receptors causes
-bronchial relaxation,
-Uterine relaxation,
Agonists Drugs
What does the autonomic system control?
smooth and cardiac muscles and glandular secretion
What does the sympathetic system do to the body
Increases HR, dilates pupils, dilates bronchi, decreases secretions, and expands
energy, "fight or flight"
Book states:
-Regulating the cardiovascular system
-Regulating body temperature
- Implementing the acute stress response (commonly called a "fight-or-flight"
reaction)
What does the parasympathetic system do to the body
Dominates at rest, Conserves energy, decreases HR, increases GI tract functions,
constricts pupils
What processes are happening for neurotransmission to occur
,Synthesis of neurotransmitters (NTs)
• Packaging of NTs in presynaptic terminals
• Stimulation of presynaptic nerve/release of NT
• Diffusion of NT across synaptic cleft & and binding to post-synaptic membrane
• Activation of the postsynaptic cell
• Degradation/reuptake of the NT
What are specific neurotransmitters in the body
Norepinephrine (NE)
• Epinephrine (Epi)
• Dopamine (DA)
• Acetylcholine (Ach)
• Also, 5-HT (Serotonin), and gamma-aminobutyric acid (GABA)
Activation of alpha 1 receptors causes.....
-Vasoconstriction
-↓secretions
-pupil dilation
-↓GI motility
-urinary retention
, Activation of alpha 2 receptors causes
-↓CNS sympathetic outflow(postsynaptic),
-↓NE release (presynaptic),
-↓insulin release
Name DIRECT acting sympathetic agonists
Epinephrine, Norepinephrine, dopamine, dobutamine, phenylephrine, Terbutaline,
Mirabegron
Activation of Beta 1 receptors causes...
↑HR,
↑CO,
↑automaticity,
↑contractility,
↑renin secretion
Activation of Beta 2 receptors causes
-bronchial relaxation,
-Uterine relaxation,
