NU 578 UNIT 1
PHARMACOLOGY UNIT
1 EXAM
Full term
36-40 weeks gestation
Ganglionic blocking agents
Interrupt impulse transmission through ganglia of the autonomic nervous system.
They do this by competing with Ach for binding to nicotinic receptors in autonomic
ganglia.
Generic name
Assigned by US Adopted Names Council. -each drug has only ONE -aka
nonproprietary name or US Adopted Name
Glomerular filtration
,Moves drugs from the blood into the tubular urine within the glomerulus of the
Bowman's capsule.
Half life
The time it takes for a drug to be 50% of its original concentration in the body. The
time required for the amount of dug in the body to decrease by 50%.
Hepatic metabolism
Is low in newborns.
Hepatic microsomal enzyme system
a.k.a. P450 system which an enzyme system consisting of 12 closely enzyme
families in the liver involved with metabolizing drugs. Cyochrome P450 is a key
component of the system. These enzymes are capable of catalyzing a wide variety of
reactions using drugs as substrate.
Hepatotoxic drugs
Drugs that cause injury to the liver. Patients taking these should have liver function
tests to check liver enzymes: aspartate aminotransferase (AST, formerly known as
SGOT) and alanine aminotransferase (ALT, formerly known as SGPT).
, Latrogenic disease
A disease produced by drugs.
Idiosyncratic effect
An uncommon drug response resulting from a genetic predisposition.
Inactivation
Drug metabolism can convert pharmacologically active compounds to inactive
forms.
Induction
The process of stimulating liver enzyme synthesis to increase the drug-metabolizing
capacity of the liver.
Infants
weeks 5-52
Intramuscular administration
PHARMACOLOGY UNIT
1 EXAM
Full term
36-40 weeks gestation
Ganglionic blocking agents
Interrupt impulse transmission through ganglia of the autonomic nervous system.
They do this by competing with Ach for binding to nicotinic receptors in autonomic
ganglia.
Generic name
Assigned by US Adopted Names Council. -each drug has only ONE -aka
nonproprietary name or US Adopted Name
Glomerular filtration
,Moves drugs from the blood into the tubular urine within the glomerulus of the
Bowman's capsule.
Half life
The time it takes for a drug to be 50% of its original concentration in the body. The
time required for the amount of dug in the body to decrease by 50%.
Hepatic metabolism
Is low in newborns.
Hepatic microsomal enzyme system
a.k.a. P450 system which an enzyme system consisting of 12 closely enzyme
families in the liver involved with metabolizing drugs. Cyochrome P450 is a key
component of the system. These enzymes are capable of catalyzing a wide variety of
reactions using drugs as substrate.
Hepatotoxic drugs
Drugs that cause injury to the liver. Patients taking these should have liver function
tests to check liver enzymes: aspartate aminotransferase (AST, formerly known as
SGOT) and alanine aminotransferase (ALT, formerly known as SGPT).
, Latrogenic disease
A disease produced by drugs.
Idiosyncratic effect
An uncommon drug response resulting from a genetic predisposition.
Inactivation
Drug metabolism can convert pharmacologically active compounds to inactive
forms.
Induction
The process of stimulating liver enzyme synthesis to increase the drug-metabolizing
capacity of the liver.
Infants
weeks 5-52
Intramuscular administration
