PHARMACOLOGY
FUNDAMENTALS FINAL EXAM -
CHAMBERLAIN (LATEST 2025 /
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Drugs that reduce absorption of levothyroxine
, Histamine 2 (H2) receptor blockers (e.g., cimetidine [Tagamet])
Proton pump inhibitors (e.g., lansoprazole [Prevacid])
Sucralfate (Carafate)
Cholestyramine (Questran)
Colestipol (Colestid)
Aluminum-containing antacids (e.g., Maalox, Mylanta)
Calcium supplements (e.g., Tums, Os-Cal)
Iron supplements (e.g., ferrous sulfate)
Magnesium salts
Orlistat (Xenical)
administer 4 hours apart from levothyroxine
Food interactions with levothyroxine
Food decreases absorption. Should be taken on an empty stomach 30-60 minutes prior to
breakfast
Drugs that accelerate levothyroxine metabolism
phenytoin (Dilantin)
carbamazepine (Tegretol, Carbatrol)
rifampin (Rifadin)
sertraline (Zoloft)
phenobarbital.
*To maintain adequate levothyroxine levels, patients taking these drugs may need to increase
their levothyroxine dosage.
*Digoxin and Insulin may have more requirements when taking levothyroxine
Which laboratory tests should be completed before prescribing methimazole?
free triiodothyronine (T3)
free thyroxine (T4)
LFTs
thyroid-stimulating hormone (TSH)