NUSCTX 11 UPDATED ACTUAL Exam
Questions and CORRECT Answers
What does ED50 refer to? - CORRECT ANSWER - Dose at which 50% of subjects
experience effectiveness from a drug
What does LD50 refer to? - CORRECT ANSWER - Dose at which 50% of subjects
experience lethality from a chemical
How do you calculate the therapeutic index? - CORRECT ANSWER - Ratio of
LD50/ED50
For a drug to have minimal toxicity, what type or ratio do you want for your therapeutic index? -
CORRECT ANSWER - A large number
What is the difference between on and off-target toxicity? - CORRECT ANSWER - On
target toxicity is when you get toxicity through your therapeutic target, whereas off-target
toxicity is when you get toxicity from targeting a protein that is not your therapeutic target
How do ibuprofen, Tylenol, and other non-steroidal anti inflammatory drugs (NSAIDS) act to
inhibit pain, fever, and inflammation? - CORRECT ANSWER - They inhibit
cyclooxyrgenase 1 and 2 (cox 1/Cox 2) to reduce pro-inflammatory prostaglandins/eicosanoids
What type of toxicity is associated with NSAIDS, what is the mechanism of toxicity, and is this
on or off-target toxicity - CORRECT ANSWER - Gastrointestinal bleeding, on-target
toxicity
How does Benadryl exert its anti-allergenic effects/ - CORRECT ANSWER -
Antagonizing histamine receptors
What toxicity does Benadryl exert ad what is the mechanism and is this on or off-target toxicity -
CORRECT ANSWER - Drowsiness, antagonizing histamine receptor, on-target
Questions and CORRECT Answers
What does ED50 refer to? - CORRECT ANSWER - Dose at which 50% of subjects
experience effectiveness from a drug
What does LD50 refer to? - CORRECT ANSWER - Dose at which 50% of subjects
experience lethality from a chemical
How do you calculate the therapeutic index? - CORRECT ANSWER - Ratio of
LD50/ED50
For a drug to have minimal toxicity, what type or ratio do you want for your therapeutic index? -
CORRECT ANSWER - A large number
What is the difference between on and off-target toxicity? - CORRECT ANSWER - On
target toxicity is when you get toxicity through your therapeutic target, whereas off-target
toxicity is when you get toxicity from targeting a protein that is not your therapeutic target
How do ibuprofen, Tylenol, and other non-steroidal anti inflammatory drugs (NSAIDS) act to
inhibit pain, fever, and inflammation? - CORRECT ANSWER - They inhibit
cyclooxyrgenase 1 and 2 (cox 1/Cox 2) to reduce pro-inflammatory prostaglandins/eicosanoids
What type of toxicity is associated with NSAIDS, what is the mechanism of toxicity, and is this
on or off-target toxicity - CORRECT ANSWER - Gastrointestinal bleeding, on-target
toxicity
How does Benadryl exert its anti-allergenic effects/ - CORRECT ANSWER -
Antagonizing histamine receptors
What toxicity does Benadryl exert ad what is the mechanism and is this on or off-target toxicity -
CORRECT ANSWER - Drowsiness, antagonizing histamine receptor, on-target
