IL MPJE
IL MPJE EXAM GUIDE QUESTIONS WITH
CORRECT DETAILED ANSWERS TOP
GRADED 2025
When can a controlled substance be returned to a pharmacy? (3) -Correct Answer ✔1.
Dispensing error
2. Drug recall
3. Authorized collector
Who can be authorized collectors of controlled substances? (6) -Correct Answer ✔1.
Manufacturers
2. Distributors
3. Reverse distributors
4. Narcotic treatment programs
5. Hospitals/clinics with on-site pharmacy
6. Retail pharmacies
What are the 2 ways for an authorized collector to take back controlled substances? -
Correct Answer ✔1. Maintaining collection receptacles
2. Mail-back programs
What are the functions of the DEA associated with the Controlled Substance Act? (4) -
Correct Answer ✔- interpretation
- implementation
- enforcement
- development of regulations
T/F: Law enforcement agencies are permitted to take back controlled substances
without DEA registration -Correct Answer ✔True
What is the method of destruction for controlled substances? -Correct Answer ✔No
specific instructions, but must be "non-retrievable" (permanently altering the controlled
substance's physical or chemical condition by irreversible means)
T/F: Patients are required to bring controlled substances to an authorized collector and
aren't permitted to destroy substances themselves -Correct Answer ✔False - aren't
required and are permitted to destroy substances themselves
What are 5 categories must register with the DEA when it comes to controlled
substance? -Correct Answer ✔1. Manufacturer
2. Distributor
3. Dispenser
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,IL MPJE
4. Narcotic treatment programs
5. Detox compounder
What type of registration do physicians and mid-level practitioners obtain in order to
prescribe controlled sustances? -Correct Answer ✔Dispenser
What is a narcotic? (6) -Correct Answer ✔Any of the following whether produced directly
or indirectly:
1. Opium, opiates and its derivatives
2. Poppy straw
3. Coca leaves
4. Cocaine
5. Ecgonine
6. Any compound/mixture/preparation which contains any of 1-5
When an entity applies for DEA registration, the registration form is signed by the
"owner", who is: (3) -Correct Answer ✔1. "Sole proprietor" if the entity is a sole
proprietorship
2. Partnership: any partner is the owner, and can complete the form
3. Corporation: any officer or director of the corporation can complete the form
What is a power of attorney? -Correct Answer ✔Method of delegating responsibility to
another person to issue orders for and obtain schedule I and II controlled substances
Who must the POA for the DEA Form 222 be executed and signed by? -Correct Answer
✔- the registrant
- person who POA is granted to
- 2 witnesses
If revoking the POA for DEA Form 222, who must revoke the notice of revocation? -
Correct Answer ✔- person who signed the most recent DEA registration
- 2 witnesses
Who can be a POA? Who is preferred to be a POA? -Correct Answer ✔Can be anyone:
non-pharmacist owners, techs, interns, and unlicensed persons. BUT it is always
preferable (even if not legally required) that only pharmacists order controlled
substances
What type of DEA registration do pharmacies apply for? -Correct Answer ✔Dispenser
Which DEA Form do pharmacies and other dispensers use for initial registration? What
form is used for renewal? How often is renewal? -Correct Answer ✔DEA 224; DEA
224a; 3 years
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,IL MPJE
Neither federal or IL law require the DEA registration applicant or the person with POA
to be a pharmacist; however, under state law, the ordering, securing, and dispensing of
controlled substance is responsibility of ____, regardless of whether they are the
registrant and regardless of whether they have a POA. -Correct Answer ✔PIC
Hospitals register as "___ ____" - registration is issued to the entire hospital, allowing
controlled substances to be stored anywhere in the registered location, and to give
employee practitioners, nurses, pharmacists the authority to possess, prescribe,
dispense, and administer controlled substances -Correct Answer ✔Institutional
practitioners
T/F: Pharmacies in hospitals require a separate DEA registration -Correct Answer
✔False - can use the institutional dispenser registration issued to hospital
T/F: Institutional practitioner registration is also available to clinics that are licensed
under state law -Correct Answer ✔True
When are multiple DEA registrations required? (2) -Correct Answer ✔1. Location:
required for each site w/ different street addresses
2. Activity: for each activity, even if in the same address (i.e. distributor, detox
compounder, etc.)
What are 3 activities would trigger multiple DEA registrations for pharmacies? -Correct
Answer ✔1. Pharmacy as a distributor
2. Pharmacy as a manufacturer
3. Pharmacy as "detox compounder"
What makes a pharmacy a distributor? -Correct Answer ✔1. Participates in joint buying
activities, and is the location from which drugs are stored and shipped to other
pharmacies OR
2. Its annual distribution of controlled substances to other pharmacies or practitioners
exceeds 5% of total number of dosage units dispensed
What makes a pharmacy a manufacturer? -Correct Answer ✔1. It purchases controlled
substances for the purpose of repackaging for sale within the pharmacy w/o a
prescription or to other registrants
2. It compounds for office use (note that this is no longer legal)
What makes a pharmacy a detox compounder? -Correct Answer ✔It compounds
controlled substance product for sale or distribution to a narcotic treatment program for
purposes of addiction treatment
Which DEA Form do manufacturers, wholesalers, importers, exporters, and researchers
use to register? What form is used to renew? How often is renewal? -Correct Answer
✔225; 225a; 3 years
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, IL MPJE
If the Applicant has done the following, the DEA may deny registration: (4) -Correct
Answer ✔1. Falsified info
2. Drug-related felony conviction
3. Committed such acts to make registration inconsistent w/ public interest
4. State license suspended, revoked, or denied
When can DEA revoke registration? (5) -Correct Answer ✔1. Falsified info
2. Drug-related felony conviction
3. Committed such acts to make registration inconsistent w/ public interest
4. State license suspended, revoked, or denied
5. Has been subject to mandatory exclusion from Medicare or any state healthcare
program
What is required in order to dispense controlled substances in IL? (3) -Correct Answer
✔1. DEA registration
2. Pharmacy or other practitioner's state professional license
3. State controlled substance license registration
What is required for IL controlled substance registration? (2) -Correct Answer ✔1. Proof
of federal registration
2. Registration fee
When does the IL controlled substance registration expire? -Correct Answer ✔Expires
on date certificate holders pharmacy license expires (March 31 on even years)
What type of license does a pharmacy in IL possess in order to dispense all RX drugs?
(3) -Correct Answer ✔1. 1. DEA registration
2. Pharmacy license
3. State controlled substance license registration
Hospital/clinic/practitioner/teaching institution/pharmacy DEA letters -Correct Answer
✔A/B/F/G
Mid-level practitioner DEA letter -Correct Answer ✔M
Reverse distributors DEA letter -Correct Answer ✔L
Manufacturer/distributor/researcher/analytical lab/importer/exporter/reverse
distributor/narcotic treatment program DEA number -Correct Answer ✔P/R
DEA letter used by a practitioner of addictions on an outpatient basis -Correct Answer
✔X
Issued and used in addition to the A/B/F/G DEA number
4|Page
IL MPJE EXAM GUIDE QUESTIONS WITH
CORRECT DETAILED ANSWERS TOP
GRADED 2025
When can a controlled substance be returned to a pharmacy? (3) -Correct Answer ✔1.
Dispensing error
2. Drug recall
3. Authorized collector
Who can be authorized collectors of controlled substances? (6) -Correct Answer ✔1.
Manufacturers
2. Distributors
3. Reverse distributors
4. Narcotic treatment programs
5. Hospitals/clinics with on-site pharmacy
6. Retail pharmacies
What are the 2 ways for an authorized collector to take back controlled substances? -
Correct Answer ✔1. Maintaining collection receptacles
2. Mail-back programs
What are the functions of the DEA associated with the Controlled Substance Act? (4) -
Correct Answer ✔- interpretation
- implementation
- enforcement
- development of regulations
T/F: Law enforcement agencies are permitted to take back controlled substances
without DEA registration -Correct Answer ✔True
What is the method of destruction for controlled substances? -Correct Answer ✔No
specific instructions, but must be "non-retrievable" (permanently altering the controlled
substance's physical or chemical condition by irreversible means)
T/F: Patients are required to bring controlled substances to an authorized collector and
aren't permitted to destroy substances themselves -Correct Answer ✔False - aren't
required and are permitted to destroy substances themselves
What are 5 categories must register with the DEA when it comes to controlled
substance? -Correct Answer ✔1. Manufacturer
2. Distributor
3. Dispenser
1|Page
,IL MPJE
4. Narcotic treatment programs
5. Detox compounder
What type of registration do physicians and mid-level practitioners obtain in order to
prescribe controlled sustances? -Correct Answer ✔Dispenser
What is a narcotic? (6) -Correct Answer ✔Any of the following whether produced directly
or indirectly:
1. Opium, opiates and its derivatives
2. Poppy straw
3. Coca leaves
4. Cocaine
5. Ecgonine
6. Any compound/mixture/preparation which contains any of 1-5
When an entity applies for DEA registration, the registration form is signed by the
"owner", who is: (3) -Correct Answer ✔1. "Sole proprietor" if the entity is a sole
proprietorship
2. Partnership: any partner is the owner, and can complete the form
3. Corporation: any officer or director of the corporation can complete the form
What is a power of attorney? -Correct Answer ✔Method of delegating responsibility to
another person to issue orders for and obtain schedule I and II controlled substances
Who must the POA for the DEA Form 222 be executed and signed by? -Correct Answer
✔- the registrant
- person who POA is granted to
- 2 witnesses
If revoking the POA for DEA Form 222, who must revoke the notice of revocation? -
Correct Answer ✔- person who signed the most recent DEA registration
- 2 witnesses
Who can be a POA? Who is preferred to be a POA? -Correct Answer ✔Can be anyone:
non-pharmacist owners, techs, interns, and unlicensed persons. BUT it is always
preferable (even if not legally required) that only pharmacists order controlled
substances
What type of DEA registration do pharmacies apply for? -Correct Answer ✔Dispenser
Which DEA Form do pharmacies and other dispensers use for initial registration? What
form is used for renewal? How often is renewal? -Correct Answer ✔DEA 224; DEA
224a; 3 years
2|Page
,IL MPJE
Neither federal or IL law require the DEA registration applicant or the person with POA
to be a pharmacist; however, under state law, the ordering, securing, and dispensing of
controlled substance is responsibility of ____, regardless of whether they are the
registrant and regardless of whether they have a POA. -Correct Answer ✔PIC
Hospitals register as "___ ____" - registration is issued to the entire hospital, allowing
controlled substances to be stored anywhere in the registered location, and to give
employee practitioners, nurses, pharmacists the authority to possess, prescribe,
dispense, and administer controlled substances -Correct Answer ✔Institutional
practitioners
T/F: Pharmacies in hospitals require a separate DEA registration -Correct Answer
✔False - can use the institutional dispenser registration issued to hospital
T/F: Institutional practitioner registration is also available to clinics that are licensed
under state law -Correct Answer ✔True
When are multiple DEA registrations required? (2) -Correct Answer ✔1. Location:
required for each site w/ different street addresses
2. Activity: for each activity, even if in the same address (i.e. distributor, detox
compounder, etc.)
What are 3 activities would trigger multiple DEA registrations for pharmacies? -Correct
Answer ✔1. Pharmacy as a distributor
2. Pharmacy as a manufacturer
3. Pharmacy as "detox compounder"
What makes a pharmacy a distributor? -Correct Answer ✔1. Participates in joint buying
activities, and is the location from which drugs are stored and shipped to other
pharmacies OR
2. Its annual distribution of controlled substances to other pharmacies or practitioners
exceeds 5% of total number of dosage units dispensed
What makes a pharmacy a manufacturer? -Correct Answer ✔1. It purchases controlled
substances for the purpose of repackaging for sale within the pharmacy w/o a
prescription or to other registrants
2. It compounds for office use (note that this is no longer legal)
What makes a pharmacy a detox compounder? -Correct Answer ✔It compounds
controlled substance product for sale or distribution to a narcotic treatment program for
purposes of addiction treatment
Which DEA Form do manufacturers, wholesalers, importers, exporters, and researchers
use to register? What form is used to renew? How often is renewal? -Correct Answer
✔225; 225a; 3 years
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, IL MPJE
If the Applicant has done the following, the DEA may deny registration: (4) -Correct
Answer ✔1. Falsified info
2. Drug-related felony conviction
3. Committed such acts to make registration inconsistent w/ public interest
4. State license suspended, revoked, or denied
When can DEA revoke registration? (5) -Correct Answer ✔1. Falsified info
2. Drug-related felony conviction
3. Committed such acts to make registration inconsistent w/ public interest
4. State license suspended, revoked, or denied
5. Has been subject to mandatory exclusion from Medicare or any state healthcare
program
What is required in order to dispense controlled substances in IL? (3) -Correct Answer
✔1. DEA registration
2. Pharmacy or other practitioner's state professional license
3. State controlled substance license registration
What is required for IL controlled substance registration? (2) -Correct Answer ✔1. Proof
of federal registration
2. Registration fee
When does the IL controlled substance registration expire? -Correct Answer ✔Expires
on date certificate holders pharmacy license expires (March 31 on even years)
What type of license does a pharmacy in IL possess in order to dispense all RX drugs?
(3) -Correct Answer ✔1. 1. DEA registration
2. Pharmacy license
3. State controlled substance license registration
Hospital/clinic/practitioner/teaching institution/pharmacy DEA letters -Correct Answer
✔A/B/F/G
Mid-level practitioner DEA letter -Correct Answer ✔M
Reverse distributors DEA letter -Correct Answer ✔L
Manufacturer/distributor/researcher/analytical lab/importer/exporter/reverse
distributor/narcotic treatment program DEA number -Correct Answer ✔P/R
DEA letter used by a practitioner of addictions on an outpatient basis -Correct Answer
✔X
Issued and used in addition to the A/B/F/G DEA number
4|Page
