Walden 6630 Psychopharmacology Midterm
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Terms in this set (174)
Serotonin regulates Mood, emotion, feeding, and reproductive behavior
SSRIs
This class of antidepressants
binds to presynaptic SERT
and inhibits them from
reuptake of serotonin to
increase levels in the synaptic
cleft to bind with
postsysnaptic 5HT2 receptors
,First line therapy for MDD SSRIs
due to milder side effect
profiles
Six Common SSRIs citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline,
paroxetine
Onset of therapeutic benefit 4-6 weeks
from SSRIs
In addition to MDD, SSRIs Chronic Anxiety, PTSD, OCD, and eating disorders
also treat (bulimia)
Five Common side effects of Anxiety, insomnia, GI distress, sexual dysfunction (ED),
SSRIs include SIADH
Severe side effect of SSRIs in suicidal ideation
children/adolescents under
age 25 years old
Life threatening adverse Serotonin Syndrome
effect of SSRIs, especially
when used in combination
with other serotonergic
drugs (SNRIs, TCAs,
MAOIs, etc.)
Excess accumulation of Serotonin Syndrome
serotonin resulting in
overstimulation of the
nervous system
Seven symptoms of Flushing, hyperthermia, agitation, muscle rigidity, seizure,
Serotonin Syndrome coma, HYPERreflexia
The treatment for serotonin Cyproheptadine (5-HT2 receptor antagonist)
syndrome
Cyproheptadine treats blocking 5-HT2 receptors (serotonin antagonist)
serotonin syndrome by
, When SSRIs or SNRIs are Irritability, headaches, and insomnia
stopped abruptly, common
symptoms of withdrawal
include
Medicine specific side effect Prolonged QT interval (normal=0.4.-0.44 seconds)
of citalopram
This SSRI is pregnancy Paroxetine
category D due to
associations with
congenital heart defects
All SSRIs but paroxetine C
(D) are pregnancy
category
Three SSRIs that are fluoxetine, fluvoxamine, and paroxetine
inhibitors of Cytochrome
P450 enzymes
Five common SNRIs include duloxetine, venlafaxine, desvenlafaxine, milnacipran,
levomilnacipran
This antidepressant class of SNRIs
medications works by
binding to presynaptic SERT
and NET to inhibit them
from reuptake of serotonin
and norepinephrine to
increase their levels in the
synaptic cleft
In addition to MDD SNRIs Anxiety and neuropathic pain (peripheral neuropathy)
treat
Medication specific urinary incontinence and Fibromyalgia
indications of duloxetine:
Medication specific social anxiety, panic disorders, PTSD, OCD, postmenopausal hot
indications of venlafaxine: flashes
Study Guide / All-In-One Comprehensive Study
Guide – Expert Strategies, Full Review of Key
Topics, and Practice Questions for Guaranteed
Succes
Practice questions for this set
Learn
Studied terms
Nice work, you're crushing it
Continue studying in Learn
Terms in this set (174)
Serotonin regulates Mood, emotion, feeding, and reproductive behavior
SSRIs
This class of antidepressants
binds to presynaptic SERT
and inhibits them from
reuptake of serotonin to
increase levels in the synaptic
cleft to bind with
postsysnaptic 5HT2 receptors
,First line therapy for MDD SSRIs
due to milder side effect
profiles
Six Common SSRIs citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline,
paroxetine
Onset of therapeutic benefit 4-6 weeks
from SSRIs
In addition to MDD, SSRIs Chronic Anxiety, PTSD, OCD, and eating disorders
also treat (bulimia)
Five Common side effects of Anxiety, insomnia, GI distress, sexual dysfunction (ED),
SSRIs include SIADH
Severe side effect of SSRIs in suicidal ideation
children/adolescents under
age 25 years old
Life threatening adverse Serotonin Syndrome
effect of SSRIs, especially
when used in combination
with other serotonergic
drugs (SNRIs, TCAs,
MAOIs, etc.)
Excess accumulation of Serotonin Syndrome
serotonin resulting in
overstimulation of the
nervous system
Seven symptoms of Flushing, hyperthermia, agitation, muscle rigidity, seizure,
Serotonin Syndrome coma, HYPERreflexia
The treatment for serotonin Cyproheptadine (5-HT2 receptor antagonist)
syndrome
Cyproheptadine treats blocking 5-HT2 receptors (serotonin antagonist)
serotonin syndrome by
, When SSRIs or SNRIs are Irritability, headaches, and insomnia
stopped abruptly, common
symptoms of withdrawal
include
Medicine specific side effect Prolonged QT interval (normal=0.4.-0.44 seconds)
of citalopram
This SSRI is pregnancy Paroxetine
category D due to
associations with
congenital heart defects
All SSRIs but paroxetine C
(D) are pregnancy
category
Three SSRIs that are fluoxetine, fluvoxamine, and paroxetine
inhibitors of Cytochrome
P450 enzymes
Five common SNRIs include duloxetine, venlafaxine, desvenlafaxine, milnacipran,
levomilnacipran
This antidepressant class of SNRIs
medications works by
binding to presynaptic SERT
and NET to inhibit them
from reuptake of serotonin
and norepinephrine to
increase their levels in the
synaptic cleft
In addition to MDD SNRIs Anxiety and neuropathic pain (peripheral neuropathy)
treat
Medication specific urinary incontinence and Fibromyalgia
indications of duloxetine:
Medication specific social anxiety, panic disorders, PTSD, OCD, postmenopausal hot
indications of venlafaxine: flashes
