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- Collaborate with dietician
- Family members encouraged to bring nutritious and favorite foods to the hospital
- High-calorie nutritional supplements prescribed
- Document nutritional intake accurately
- If caloric goals cannot be met by oral feeding, a feeding tube is inserted
- Weigh daily
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, Nutrition in burn patients
Nutritional status
Skin integrity
Respiratory status
Neuro status
Fluid & electrolyte balance
Knowledge level
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Assessment of patient with HIV/AIDS
- Total excision of the lesion often is not possible for two reasons: (1) extensive growth
of tumor before diagnosis and (2) probable widespread metastases (especially to the
liver, lungs, and bones).
- Radiation & chemotherapy
- Gemcitabine is the standard of care for patients with metastatic pancreatic cancer
and has been found to lengthen survival
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Treating pancreatic cancer
- Antiretroviral drugs that exert their effects against HIV at a different phase of its life
cycle
- Inhibits the HIV enzyme protease, which is required to process viral protein
precursors into mature particles capable of infecting other cells
- Active in both acutely and chronically infected cells
, - Prototype: Saquinavir mesylate (Invirase) "Navir tease a pro"
- ECG monitoring for long QT syndrome is necessary
- Pharmacokinetics: in GI tract with high fat meal
- Action: Binds to the site of HIV-1 protease activity to prevent the cleavage of viral
gag-pol polyproteins that are required for the maturation of the HIV virus
- Use: To reduce the viral load in HIV—in combination with other antiretroviral agents
(and for gout)
- Contraindications: Congenital or acquired prolongation of the QT interval,
atrioventricular block, hepatic impairment, refractory hypokalemia, or
hypomagnesemia.
- Interactions: St John's Wort, Grapefruit (decreases ART activity)
- Take saquinavir with ritonavir within 2 hours of a meal
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Protease inhibitors
- defined as the involuntary loss of more than 10% of one's body weight while having
experienced diarrhea or weakness and fever for more than 30 days
- Wasting refers to the loss of muscle mass, although part of the weight loss may also
be due to loss of fat.
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HIV wasting syndrome
Alkylating Drugs - cyclophosphamide
Biologic Antineoplastic Drugs - target cellular differences between the malignant and
normal cells
Monoclonal Antibodies - Alemtuzumab
Growth Factor and Tyrosine Kinase Inhibitors - Erlotinib
Proteasome Inhibitors - Bortezomib (Velcade)