USMLE Step 1 - Antibiotics + Antivirals + Antifungals
Study online at https://quizlet.com/_cv0ifr
1. Vancomycin: Cell Wall Synthesis Inhibitor
MOA
-Binds to D-Ala-D-Ala residues (Cell Wall glycoproteins) to inhibit cell wall peptido-
glycan formation
Tx
-MRSA
-C. Diff (Oral)
-S. Epidermidis
AE
-Nephrotoxicity
-Ototoxicity
-Thrombophlebitis
-Red Man Syndrome ’ Flushing + Rashes + severe Pruritus when medication is
infused too rapidly (D/t/ direct Histamine activation)
2. Bictegravir
Dolutegravir
Elvitegravir
Raltegravir: MOA
-Integrase Inhibitors
Effects
-Inhibits HIV genome integration into host cell
AE
-‘‘Creatinine Kinase
3. NRTIs
NNRTIs: MOA
-Inhibit HIV Nucleic Acid Synthesis
4. Amphotericin B
Nystatin: MOA
-Ergosterol binding
5. Terbinafine: MOA
-Inhibition of Squalene Oxidase
, USMLE Step 1 - Antibiotics + Antivirals + Antifungals
Study online at https://quizlet.com/_cv0ifr
6. Capsofungin: MOA
-Blocking of ²-D Glucan synthesis
7. Griseofulvin: MOA
-Prevent Mitosis by binding Tubulin
Effects
-Interferes w/ Microtubule function
8. Flucytosine: MOA
-Inhibition of Fungal protein synthesis
9. Fidaxomycin: Macrocyclic Antibiotic ’ Bactericidal
MOA
-Inhibits the Sigma subunit of RNA Polymerase
Tx
-C. Diff
10. Enfuvirtide: MOA
-Fusion Inhibitor
Effects
-Blocked binding to the Chemokine receptors
11. Nevirapine
Efavirenz
Delavirdine: NNRTIs
MOA
-Bind to different site (Allosterically) of Reverse Transcriptase to alter the shape of
the enzyme + inhibit the addition of new nucleotides to the growing cDNA strand
-Do NOT require phosphorylation to be active
AE
, USMLE Step 1 - Antibiotics + Antivirals + Antifungals
Study online at https://quizlet.com/_cv0ifr
-Rash
-Hepatotoxicity
--Vivid Dreams and CNS symptoms w/ Efavirenz
12. Doxycycline
Tetracycline
Minocycline: Tetracyclines
MOA
-Binds to 30S subunit of Ribosome
Effects
-Prevents attachment of tRNA to Ribosomes
AE
-Yellow discoloration of Teeth
-Bone growth inhibition
-GIT distress
Contraindications
-Pregnancy
13. Jarisch-Herxheimer Reaction: Etiology
-Penicillin G tx
Risk Factors
-Syph
Pathogen
-Massive destruction of Bacterial Cell Wall ’ Lipoproteins released into circulation ’
Transient inflammatory response
Sx
-Fever
-Chills
-Myalgias
14. ²-Lactamase: Enzyme which provided resistance to Penicillins, but it is ONLY
present in Gram "-" Bacteria
15. PBP Alterations: Enzyme which provides resistance to Penicillins, but it is
ONLY present in Gram "+" Bacteria
Study online at https://quizlet.com/_cv0ifr
1. Vancomycin: Cell Wall Synthesis Inhibitor
MOA
-Binds to D-Ala-D-Ala residues (Cell Wall glycoproteins) to inhibit cell wall peptido-
glycan formation
Tx
-MRSA
-C. Diff (Oral)
-S. Epidermidis
AE
-Nephrotoxicity
-Ototoxicity
-Thrombophlebitis
-Red Man Syndrome ’ Flushing + Rashes + severe Pruritus when medication is
infused too rapidly (D/t/ direct Histamine activation)
2. Bictegravir
Dolutegravir
Elvitegravir
Raltegravir: MOA
-Integrase Inhibitors
Effects
-Inhibits HIV genome integration into host cell
AE
-‘‘Creatinine Kinase
3. NRTIs
NNRTIs: MOA
-Inhibit HIV Nucleic Acid Synthesis
4. Amphotericin B
Nystatin: MOA
-Ergosterol binding
5. Terbinafine: MOA
-Inhibition of Squalene Oxidase
, USMLE Step 1 - Antibiotics + Antivirals + Antifungals
Study online at https://quizlet.com/_cv0ifr
6. Capsofungin: MOA
-Blocking of ²-D Glucan synthesis
7. Griseofulvin: MOA
-Prevent Mitosis by binding Tubulin
Effects
-Interferes w/ Microtubule function
8. Flucytosine: MOA
-Inhibition of Fungal protein synthesis
9. Fidaxomycin: Macrocyclic Antibiotic ’ Bactericidal
MOA
-Inhibits the Sigma subunit of RNA Polymerase
Tx
-C. Diff
10. Enfuvirtide: MOA
-Fusion Inhibitor
Effects
-Blocked binding to the Chemokine receptors
11. Nevirapine
Efavirenz
Delavirdine: NNRTIs
MOA
-Bind to different site (Allosterically) of Reverse Transcriptase to alter the shape of
the enzyme + inhibit the addition of new nucleotides to the growing cDNA strand
-Do NOT require phosphorylation to be active
AE
, USMLE Step 1 - Antibiotics + Antivirals + Antifungals
Study online at https://quizlet.com/_cv0ifr
-Rash
-Hepatotoxicity
--Vivid Dreams and CNS symptoms w/ Efavirenz
12. Doxycycline
Tetracycline
Minocycline: Tetracyclines
MOA
-Binds to 30S subunit of Ribosome
Effects
-Prevents attachment of tRNA to Ribosomes
AE
-Yellow discoloration of Teeth
-Bone growth inhibition
-GIT distress
Contraindications
-Pregnancy
13. Jarisch-Herxheimer Reaction: Etiology
-Penicillin G tx
Risk Factors
-Syph
Pathogen
-Massive destruction of Bacterial Cell Wall ’ Lipoproteins released into circulation ’
Transient inflammatory response
Sx
-Fever
-Chills
-Myalgias
14. ²-Lactamase: Enzyme which provided resistance to Penicillins, but it is ONLY
present in Gram "-" Bacteria
15. PBP Alterations: Enzyme which provides resistance to Penicillins, but it is
ONLY present in Gram "+" Bacteria
