Chapter 53. Pediatric Patients
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. The Pediatric Research Equity Acts requires:
1. All children be provided equal access to drug research trials
2. Children to be included in the planning phase of new drug development
3. That pediatric drug trials guarantee children of multiple ethnic groups are included
4. All applications for new active ingredients, new indications, new dosage forms, or
new routes of administration require pediatric studies
2. The Best Pharmaceuticals for Children Act:
1. Includes a pediatric exclusivity rule which extends the patent on drugs studied in
children
2. Establishes a committee that writes guidelines for pediatric prescribing
3. Provides funding for new drug development aimed at children
4. Encourages manufacturers specifically to develop pediatric formulations
3. The developmental variation in Phase I enzymes has what impact on pediatric prescribing?
1. None, Phase I enzymes are stable throughout childhood.
2. Children should always be prescribed lower than adult doses per weight due to low
enzyme activity until puberty.
3. Children should always be prescribed higher than adult doses per weight due to
high enzyme activity.
4. Prescribing dosages will vary based on the developmental activity of each enzyme,
at times requiring lower than adult doses and other times higher than adult doses
based on the age of the child.
4. Developmental variation in renal function has what impact on prescribing for infants and children?
, 1. Lower doses of renally excreted drugs may be prescribed to infants younger than
age 6 months.
2. Higher doses of water soluble drugs may need to be prescribed because of
increased renal excretion.
3. Renal excretion rates have no impact on prescribing.
4. Parents need to be instructed on whether drugs are renally excreted or not.
5. Topical corticosteroids are prescribed cautiously in young children because:
1. They may cause an intense hypersensitivity reaction
2. Of hypothalamic-pituitary-adrenal axis suppression
3. Corticosteroids are less effective in young children
4. Young children may accumulate corticosteroids, leading to toxic levels
6. Liza is breastfeeding her 2-month-old son and has an infection that requires an antibiotic. What drug
factors influence the effect of the drug on the infant?
1. Maternal drug levels
2. Half-life
3. Lipid-solubility
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. The Pediatric Research Equity Acts requires:
1. All children be provided equal access to drug research trials
2. Children to be included in the planning phase of new drug development
3. That pediatric drug trials guarantee children of multiple ethnic groups are included
4. All applications for new active ingredients, new indications, new dosage forms, or
new routes of administration require pediatric studies
2. The Best Pharmaceuticals for Children Act:
1. Includes a pediatric exclusivity rule which extends the patent on drugs studied in
children
2. Establishes a committee that writes guidelines for pediatric prescribing
3. Provides funding for new drug development aimed at children
4. Encourages manufacturers specifically to develop pediatric formulations
3. The developmental variation in Phase I enzymes has what impact on pediatric prescribing?
1. None, Phase I enzymes are stable throughout childhood.
2. Children should always be prescribed lower than adult doses per weight due to low
enzyme activity until puberty.
3. Children should always be prescribed higher than adult doses per weight due to
high enzyme activity.
4. Prescribing dosages will vary based on the developmental activity of each enzyme,
at times requiring lower than adult doses and other times higher than adult doses
based on the age of the child.
4. Developmental variation in renal function has what impact on prescribing for infants and children?
, 1. Lower doses of renally excreted drugs may be prescribed to infants younger than
age 6 months.
2. Higher doses of water soluble drugs may need to be prescribed because of
increased renal excretion.
3. Renal excretion rates have no impact on prescribing.
4. Parents need to be instructed on whether drugs are renally excreted or not.
5. Topical corticosteroids are prescribed cautiously in young children because:
1. They may cause an intense hypersensitivity reaction
2. Of hypothalamic-pituitary-adrenal axis suppression
3. Corticosteroids are less effective in young children
4. Young children may accumulate corticosteroids, leading to toxic levels
6. Liza is breastfeeding her 2-month-old son and has an infection that requires an antibiotic. What drug
factors influence the effect of the drug on the infant?
1. Maternal drug levels
2. Half-life
3. Lipid-solubility
