Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
Pharmacotherapeutics
for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Nurse practitioner prescriptive authority is regulated by:
1. The National Council of State Boards of Nursing
2. The U.S. Drug Enforcement Administration
3. The State Board of Nursing for each state
4. The State Board of Pharmacy
2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber
include:
1. Nurses know more about Pharmacology than other prescribers because they take it
both in their basic nursing program and in their APRN program.
2. Nurses care for the patient from a holistic approach and include the patient in
decision making regarding their care.
3. APRNs are less likely to prescribe narcotics and other controlled substances.
4. APRNs are able to prescribe independently in all states, whereas a physician’s
assistant needs to have a physician supervising their practice.
3. Clinical judgment in prescribing includes:
1. Factoring in the cost to the patient of the medication prescribed
2. Always prescribing the newest medication available for the disease process
3. Handing out drug samples to poor patients
4. Prescribing all generic medications to cut costs
4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
5. Nurse practitioner practice may thrive under health-care reform because of:
1. The demonstrated ability of nurse practitioners to control costs and improve patient
outcomes
2. The fact that nurse practitioners will be able to practice independently
3. The fact that nurse practitioners will have full reimbursement under health-care
reform
4. The ability to shift accountability for Medicaid to the state level
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner
Answer Section
MULTIPLE CHOICE
1. ANS: 3 PTS: 1
2. ANS: 2 PTS: 1
3. ANS: 1 PTS: 1
4. ANS: 2 PTS: 1
5. ANS: 1 PTS: 1
Chapter 2. Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of absorption.
3. There will be less free drug available to generate an effect.
4. Drugs bound to albumin are readily excreted by the kidneys.
2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired action
4. Are converted by the liver to more active and fat-soluble forms
3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage
reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the 3. Onset of action
prescription. This is considered a loading dose. A loading dose: 4. Therapeutic range
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
4. Is directly related to the drug circulating to the target tissues
2. When the drug will be administered for a short time only
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect 3. When there is a high correlation between the dose and saturation of receptor sites
is the: 4. To determine if a drug is in the therapeutic range
1. Minimum adverse effect level
2. Peak of action 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
2. All brands of a drug have the same bioavailability. 4. Reducing the dosage of both drugs
3. Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
23. Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
4. Combining an active drug with an inert substance does not affect bioavailability.
Which of the following would reduce or inhibit this process?
1. Protein malnutrition
16. Which of the following statements about the major distribution barriers (blood-brain or 2. Iron-deficiency anemia
fetal-placental) is true? 3. Both 1 and 2
1. Water soluble and ionized drugs cross these barriers rapidly. 4. Neither 1 nor 2
2. The blood-brain barrier slows the entry of many drugs into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the mother. 24. The time required for the amount of drug in the body to decrease by 50% is called:
4. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women. 1. Steady state
2. Half-life
17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of 3. Phase II metabolism
these types of reactions is to: 4. Reduced bioavailability time
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes 25. An agonist activates a receptor and stimulates a response. When given frequently over time,
3. Change drug molecules to a form that an excretory organ can excrete the body may:
4. Make these drugs more ionized and polar to facilitate excretion 1. Upregulate the total number of receptors
2. Block the receptor with a partial agonist
18. Once they have been metabolized by the liver, the metabolites may be: 3. Alter the drug’s metabolism
1. More active than the parent drug 4. Downregulate the numbers of that specific receptor
2. Less active than the parent drug
3. Totally ―deactivated‖ so they are excreted without any effect 26. Drug antagonism is best defined as an effect of a drug that:
4. All of the above 1. Leads to major physiological and psychological dependence
2. Is modified by the concurrent administration of another drug
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to 3. Cannot be metabolized before another dose is administered
excrete drugs via the renal system would be increased by: 4. Leads to a decreased physiological response when combined with another drug
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease 27. Instructions to a client regarding self-administration of oral enteric-coated tablets should include
3. Competition for a transport site by another drug which of the following statements?
4. Unbinding a nonvolatile drug from plasma proteins 1. ―Avoid any other oral medicines while taking this drug.‖
2. ―If swallowing this tablet is difficult, dissolve it in 3 ounces of orange juice.‖
20. Steady state is: 3. ―The tablet may be crushed if you have any difficulty taking it.‖
1. The point on the drug concentration curve when absorption exceeds excretion 4. ―To achieve best effect, take the tablet with at least 8 ounces of fluid.‖
2. When the amount of drug in the body remains constant
3. When the amount of drug in the body stays below the minimum toxic 28. The major reason for not crushing a sustained-release capsule is that, if crushed, the coated beads of
concentration the drugs could possibly result in:
4. All of the above 1. Disintegration
2. Toxicity
21. Two different pain medications are given together for pain relief. The drug—drug interaction is: 3. Malabsorption
1. Synergistic 4. Deterioration
2. Antagonistic
3. Potentiative 29. Which of the following substances is the most likely to be absorbed in the intestines rather than in
4. Additive the stomach?
1. Sodium bicarbonate
22. Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT: 2. Ascorbic acid
1. Reducing the dosage of one of the drugs 3. Salicylic acid
2. Scheduling their administration at different times 4. Glucose
3. Prescribing a third drug to counteract the adverse reaction of the combination
Pharmacotherapeutics
for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. Nurse practitioner prescriptive authority is regulated by:
1. The National Council of State Boards of Nursing
2. The U.S. Drug Enforcement Administration
3. The State Board of Nursing for each state
4. The State Board of Pharmacy
2. The benefits to the patient of having an Advanced Practice Registered Nurse (APRN) prescriber
include:
1. Nurses know more about Pharmacology than other prescribers because they take it
both in their basic nursing program and in their APRN program.
2. Nurses care for the patient from a holistic approach and include the patient in
decision making regarding their care.
3. APRNs are less likely to prescribe narcotics and other controlled substances.
4. APRNs are able to prescribe independently in all states, whereas a physician’s
assistant needs to have a physician supervising their practice.
3. Clinical judgment in prescribing includes:
1. Factoring in the cost to the patient of the medication prescribed
2. Always prescribing the newest medication available for the disease process
3. Handing out drug samples to poor patients
4. Prescribing all generic medications to cut costs
4. Criteria for choosing an effective drug for a disorder include:
1. Asking the patient what drug they think would work best for them
2. Consulting nationally recognized guidelines for disease management
3. Prescribing medications that are available as samples before writing a prescription
4. Following U.S. Drug Enforcement Administration guidelines for prescribing
5. Nurse practitioner practice may thrive under health-care reform because of:
1. The demonstrated ability of nurse practitioners to control costs and improve patient
outcomes
2. The fact that nurse practitioners will be able to practice independently
3. The fact that nurse practitioners will have full reimbursement under health-care
reform
4. The ability to shift accountability for Medicaid to the state level
,Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
Chapter 1. The Role of the Nurse Practitioner
Answer Section
MULTIPLE CHOICE
1. ANS: 3 PTS: 1
2. ANS: 2 PTS: 1
3. ANS: 1 PTS: 1
4. ANS: 2 PTS: 1
5. ANS: 1 PTS: 1
Chapter 2. Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to
prescribing because:
1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of absorption.
3. There will be less free drug available to generate an effect.
4. Drugs bound to albumin are readily excreted by the kidneys.
2. Drugs that have a significant first-pass effect:
1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little if any desired action
4. Are converted by the liver to more active and fat-soluble forms
3. The route of excretion of a volatile drug will likely be the:
1. Kidneys
2. Lungs
3. Bile and feces
4. Skin
4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage
reservoir of the drug. Storage reservoirs:
1. Assure that the drug will reach its intended target tissue
2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and active
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the 3. Onset of action
prescription. This is considered a loading dose. A loading dose: 4. Therapeutic range
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
4. Is directly related to the drug circulating to the target tissues
2. When the drug will be administered for a short time only
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect 3. When there is a high correlation between the dose and saturation of receptor sites
is the: 4. To determine if a drug is in the therapeutic range
1. Minimum adverse effect level
2. Peak of action 9. A laboratory result indicates that the peak level for a drug is above the minimum toxic concentration.
This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
, Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank Pharmacotherapeutics for Advanced Practice Nurse Prescribers 5th Edition Woo Robinson Test Bank
2. All brands of a drug have the same bioavailability. 4. Reducing the dosage of both drugs
3. Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
23. Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
4. Combining an active drug with an inert substance does not affect bioavailability.
Which of the following would reduce or inhibit this process?
1. Protein malnutrition
16. Which of the following statements about the major distribution barriers (blood-brain or 2. Iron-deficiency anemia
fetal-placental) is true? 3. Both 1 and 2
1. Water soluble and ionized drugs cross these barriers rapidly. 4. Neither 1 nor 2
2. The blood-brain barrier slows the entry of many drugs into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the mother. 24. The time required for the amount of drug in the body to decrease by 50% is called:
4. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women. 1. Steady state
2. Half-life
17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of 3. Phase II metabolism
these types of reactions is to: 4. Reduced bioavailability time
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes 25. An agonist activates a receptor and stimulates a response. When given frequently over time,
3. Change drug molecules to a form that an excretory organ can excrete the body may:
4. Make these drugs more ionized and polar to facilitate excretion 1. Upregulate the total number of receptors
2. Block the receptor with a partial agonist
18. Once they have been metabolized by the liver, the metabolites may be: 3. Alter the drug’s metabolism
1. More active than the parent drug 4. Downregulate the numbers of that specific receptor
2. Less active than the parent drug
3. Totally ―deactivated‖ so they are excreted without any effect 26. Drug antagonism is best defined as an effect of a drug that:
4. All of the above 1. Leads to major physiological and psychological dependence
2. Is modified by the concurrent administration of another drug
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to 3. Cannot be metabolized before another dose is administered
excrete drugs via the renal system would be increased by: 4. Leads to a decreased physiological response when combined with another drug
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease 27. Instructions to a client regarding self-administration of oral enteric-coated tablets should include
3. Competition for a transport site by another drug which of the following statements?
4. Unbinding a nonvolatile drug from plasma proteins 1. ―Avoid any other oral medicines while taking this drug.‖
2. ―If swallowing this tablet is difficult, dissolve it in 3 ounces of orange juice.‖
20. Steady state is: 3. ―The tablet may be crushed if you have any difficulty taking it.‖
1. The point on the drug concentration curve when absorption exceeds excretion 4. ―To achieve best effect, take the tablet with at least 8 ounces of fluid.‖
2. When the amount of drug in the body remains constant
3. When the amount of drug in the body stays below the minimum toxic 28. The major reason for not crushing a sustained-release capsule is that, if crushed, the coated beads of
concentration the drugs could possibly result in:
4. All of the above 1. Disintegration
2. Toxicity
21. Two different pain medications are given together for pain relief. The drug—drug interaction is: 3. Malabsorption
1. Synergistic 4. Deterioration
2. Antagonistic
3. Potentiative 29. Which of the following substances is the most likely to be absorbed in the intestines rather than in
4. Additive the stomach?
1. Sodium bicarbonate
22. Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT: 2. Ascorbic acid
1. Reducing the dosage of one of the drugs 3. Salicylic acid
2. Scheduling their administration at different times 4. Glucose
3. Prescribing a third drug to counteract the adverse reaction of the combination
