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Destroy growth of bacteria or fungi - ✔✔Bactericidal
Inhibit growth of bacteria or fungi - ✔✔Bacteriostatic
Primary goals of antimicrobial agents - ✔✔-Destroy (or inhibit growth of) bacteria
-At the same time, not harm host tissue
General Adverse Reactions - ✔✔Determine any previous allergy or adverse reactions
before administration!
Always ask WHAT KIND OF reaction
Allergic reactions/hypersensitivity
Rash
Fever, chills
Urticaria, pruritus
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,Generalized erythema
Anaphylaxis - 911 - ✔✔Clinical signs and symptoms
May have all of the previous reactions
Laryngeal edema (airway swelling)
Dyspnea, SOB
Hypotension, tachycardia
Treatment
Epinephrine
Antihistamines
Corticosteroids
Airway maintenance
superinfection - ✔✔Eradication or reduction of normal flora growth
Allows growth of other flora
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,Candida endogenous to body
Overgrowth
AKA yeast infection
Thrush
S/Sx: fever, perineal itching, cough, lethargy, or any unusual discharge
General Guidelines - ✔✔Identify infecting organism
Follow agency guidelines
Collect specimens
Culture and sensitivity (C & S)
Obtain before giving first dose of antibiotic
Take specimen immediately to lab
Treatment begun
Based on tentative microorganism ID
Broad-spectrum antibiotics
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, Combinations
C & S results return
Antibiotics changed to one that will fight infection best
Blood levels drawn for therapeutic levels
peak levels - ✔✔Highest blood level
Drawn 30 minutes after dose is administered (completed)
trough levels - ✔✔Lowest blood level
Drawn immediately before administering ordered dose
treatment considerations: patient defense mechanisms - ✔✔Diminished defenses
Chronic disease
Severity of infection
Renal status
Liver function
type of microorganisms - ✔✔Gram positive
Gram negative
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