N518 Inhalation Anesthetic Agents
UPDATED ACTUAL Exam Questions and
CORRECT Answers
B:G Coefficient of Sevoflurane
MAC% - CORRECT ANSWER - 0.69
2%
B:G Coefficient of Desflurane
MAC % - CORRECT ANSWER - 0.42
6-7%
B:G Coefficient of Isoflurane
MAC % - CORRECT ANSWER - 1.43
1.1%
B:G Coefficient of N2O
MAC% - CORRECT ANSWER - 0.47
104%
Oil : Gas is proportional to ______________ - CORRECT ANSWER - Potency
Blood : Gas is a measure of ____________________ - CORRECT ANSWER - Solubility
Halogenation is the addition of - CORRECT ANSWER - Fluorine (Mainly for the inhaled
anesthetics)
Chlorine
,Bromine
Iodine
Halogenation does what to an inhaled agent? - CORRECT ANSWER - Reduces flammability
Reduces toxicity
Influences potency
Unitarian hypothesis for inhalation anesthesia? - CORRECT ANSWER - proposed all
inhalational agents work via a similar MOA but not necessarily at the same site
Meyer-Overton hypothesis - CORRECT ANSWER - Recognized that the more lipid soluble
an agent was the more potent (slower onset of action)
Even though the anesthetic agents have a wide variety of structures they share the ability to alter
the lipid environment of proteins - thus changing their function
How do inhalation anesthetics produce immobility - CORRECT ANSWER - anesthetic effect
of immobility is modulated at the spinal cord and the supraspinal level
Inhalational anesthesia modulates pain by acting on what receptor type? - CORRECT
ANSWER - NMDA
Why does N2O have a faster rate of onset than Des if Des has a lower B:G coefficient? -
CORRECT ANSWER - We use N2O at a much higher concentration than we use with Des
What makes Iso more potent than Des? - CORRECT ANSWER - Iso has 5 Fluoride
molecules and instead of having a 6th it has a Cl-
This Cl- makes Iso highly soluble = more potent = slower onset of action
, What organs compose the vessel rich group that only make up 10% of the body mass but receive
75% of CO? - CORRECT ANSWER - Brain, heart, liver, kidney
Explain alveolar-to-venous partial pressure differences
Amount of CO %
Amount of body mass % - CORRECT ANSWER - This is in reference to venous blood
flow/supply to different groups within the body
Vessel Rich group make up 9% body mass (75% of CO): Brian, Heart, Kidneys, Liver
Muscle make up 50% body mass (18% CO): skeletal/smooth muscle, skin
Fat makes up 19% body mass (5% CO):
Vessel Poor Group makes up 22% body mass (2% CO): bone, ligaments, tendons
Order of metabolism of inhaled anesthetics - CORRECT ANSWER - Methoxyflurane
Halothane (15-20% hepatic metabolism)
Enflurane
Sevoflurane
Isoflurane
Desflurane
N2O
What is Trifluoromethyl Vinyl Ether? - CORRECT ANSWER - Compound A; product of sevo
degradation via CO2 absorber
List factors that will Increase MAC requirements - CORRECT ANSWER - Hyperthermia
Hypernatremia
UPDATED ACTUAL Exam Questions and
CORRECT Answers
B:G Coefficient of Sevoflurane
MAC% - CORRECT ANSWER - 0.69
2%
B:G Coefficient of Desflurane
MAC % - CORRECT ANSWER - 0.42
6-7%
B:G Coefficient of Isoflurane
MAC % - CORRECT ANSWER - 1.43
1.1%
B:G Coefficient of N2O
MAC% - CORRECT ANSWER - 0.47
104%
Oil : Gas is proportional to ______________ - CORRECT ANSWER - Potency
Blood : Gas is a measure of ____________________ - CORRECT ANSWER - Solubility
Halogenation is the addition of - CORRECT ANSWER - Fluorine (Mainly for the inhaled
anesthetics)
Chlorine
,Bromine
Iodine
Halogenation does what to an inhaled agent? - CORRECT ANSWER - Reduces flammability
Reduces toxicity
Influences potency
Unitarian hypothesis for inhalation anesthesia? - CORRECT ANSWER - proposed all
inhalational agents work via a similar MOA but not necessarily at the same site
Meyer-Overton hypothesis - CORRECT ANSWER - Recognized that the more lipid soluble
an agent was the more potent (slower onset of action)
Even though the anesthetic agents have a wide variety of structures they share the ability to alter
the lipid environment of proteins - thus changing their function
How do inhalation anesthetics produce immobility - CORRECT ANSWER - anesthetic effect
of immobility is modulated at the spinal cord and the supraspinal level
Inhalational anesthesia modulates pain by acting on what receptor type? - CORRECT
ANSWER - NMDA
Why does N2O have a faster rate of onset than Des if Des has a lower B:G coefficient? -
CORRECT ANSWER - We use N2O at a much higher concentration than we use with Des
What makes Iso more potent than Des? - CORRECT ANSWER - Iso has 5 Fluoride
molecules and instead of having a 6th it has a Cl-
This Cl- makes Iso highly soluble = more potent = slower onset of action
, What organs compose the vessel rich group that only make up 10% of the body mass but receive
75% of CO? - CORRECT ANSWER - Brain, heart, liver, kidney
Explain alveolar-to-venous partial pressure differences
Amount of CO %
Amount of body mass % - CORRECT ANSWER - This is in reference to venous blood
flow/supply to different groups within the body
Vessel Rich group make up 9% body mass (75% of CO): Brian, Heart, Kidneys, Liver
Muscle make up 50% body mass (18% CO): skeletal/smooth muscle, skin
Fat makes up 19% body mass (5% CO):
Vessel Poor Group makes up 22% body mass (2% CO): bone, ligaments, tendons
Order of metabolism of inhaled anesthetics - CORRECT ANSWER - Methoxyflurane
Halothane (15-20% hepatic metabolism)
Enflurane
Sevoflurane
Isoflurane
Desflurane
N2O
What is Trifluoromethyl Vinyl Ether? - CORRECT ANSWER - Compound A; product of sevo
degradation via CO2 absorber
List factors that will Increase MAC requirements - CORRECT ANSWER - Hyperthermia
Hypernatremia
