Comprehensive Pathophysiology Midterm Exam Questions and Answers for Guaranteed Success

Comprehensive Pathophysiology Midterm Exam Questions and Answers for Guaranteed Success What are the two categories of intracellular accumulations? - ANS (1) normal cellular substances, such as water, proteins, lipids, and carbohydrate excesses; and (2) abnormal substances, either endogenous (e.g., from abnormal metabolism) or exogenous (e.g., a virus). What mechanisms cause accumulations? - ANS (1) An endogenous substance is produced in excess or at an increased rate; (2) an abnormal substance, often the result of a mutated gene, accumulates; (3) an endogenous substance is not effectively catabolized; and (4) a harmful exogenous substance accumulates because of inhalation, ingestion, or infection. What causes cellular swelling? - ANS the failure of transport mechanisms and is a sign of many types of cellular injury What is dystrophic calcification? - ANS hallmark of CELLULAR INJURY and occurs in all types of cell NECROSIS always in the setting of NORMAL CALCIUM LEVELS, and results in PSAMMOMA BODIES What does a disturbance in urate metabolism cause? - ANS hyperuricemia and deposition of sodium urate crystals in tissue—leading to a painful disorder called gout What are the systemic manifestations of cellular injury? - ANS fever, leukocytosis, increased heart rate, pain, and serum elevations of enzymes in the plasma What is necrosis? - ANS rapid loss of the plasma membrane structure, organelle swelling, mitochondrial dysfunction, and the lack of features of apoptosis What is apoptosis? - ANS regulated or programmed cell death and is characterized by "dropping off" of cellular fragments, called apoptotic bodies How are cells specialized? - ANS through the process of differentiation or maturation What are the eight specialized cellular functions? - ANS movement, conductivity, metabolic absorption, secretion, excretion, respiration, reproduction, and communication What are the three general components of an eukaryotic cell? - ANS the plasma membrane, the cytoplasm, and the intracellular organelles. What causes the release of lysosomal enzemes? - ANS Cellular injury causing cellular self-digestion What is the location and function of the nucleus? - ANS the largest membrane-bound organelle and is found usually in the cell's center. The chief functions of the nucleus are cell division and control of genetic information. What is Cytoplasm? - ANS an aqueous solution (cytosol) that fills the space between the nucleus and the plasma membrane. What is the endoplasmic reticulum and what does it specialize in? - ANS a network of tubular channels (cisternae) that extend throughout the outer nuclear membrane. It specializes in the synthesis and transport of protein and lipid components of most of the organelles What is the Golgi complex and what does it do? - ANS a network of smooth membranes and vesicles located near the nucleus. The Golgi complex is responsible for processing and packaging proteins into secretory vesicles What are lysosomes and what do they do? - ANS saclike structures that originate from the Golgi complex and contain digestive enzymes. These enzymes are responsible for digesting most cellular substances to their basic form, such as amino acids, fatty acids, and carbohydrates What are peroxisomes? - ANS involved in the production and breakdown of hydrogen peroxide Importance of proteins in disease - ANS The major workhorses of the cell, if misfolded they can cause diseases What are mitochondria responsible for? - ANS . Mitochondria contain the metabolic machinery necessary for cellular energy metabolism (Makes ATP). What is the cytoskeleton? - ANS the "bone and muscle" of the cell. The internal skeleton is composed of a network of protein filaments, including microtubules and actin filaments (microfilaments). What is the plasma membrane? - ANS encloses the cell and, by controlling the movement of substances across it, exerts a powerful influence on metabolic pathways What is signal transduction? - ANS The transfer of molecular signals from the exterior to the interior of a cell. If not done apoptosis occurs What is protein regulation and what is it composed of? - ANS protein homeostasis and is defined by the proteostasis network. This network is composed of ribosomes (makers), chaperones (helpers), and protein breakdown or proteolytic systems. Malfunction of these systems is associated with disease. What do protein receptors do? - ANS on the plasma membrane, enable the cell to interact with other cells and with extracellular substances What means accomplish cell-to-cell adhesions? - ANS (1) the extracellular membrane, (2) cell adhesion molecules in the cell's plasma membrane, and (3) specialized cell junctions. What makes up the extracellular matrix and what does it do? - ANS (1) fibrous structural proteins (collagen and elastin), (2) adhesive glycoproteins, and (3) proteoglycans and hyaluronic acid. The matrix helps regulate cell growth, movement, and differentiation. How do cells communicate? - ANS (1) they form protein channels (gap junctions); (2) they display receptors that affect intracellular processes or other cells in direct physical contact; and (3) they use receptor proteins inside the target cell. How is intercellular signaling done? - ANS contact-dependent, paracrine, hormonal, neurohormonal, and neurotransmitter. What is ATP? - ANS Adenosine Triphosphate - ENERGY - is required for active transport. What is anabolism? - ANS energy-using process of metabolism What is catabolism? - ANS the energy-releasing process of metabolism What is passive transport? - ANS The movement of materials across the cell membrane without using cellular energy, water and small electrically uncharged molecules, done through osmosis What is oxidative phosphorylation? - ANS occurs in the mitochondria and is the mechanism by which the energy produced from carbohydrates, fats, and proteins is transferred to ATP. What is endocytosis and exocytosis? - ANS Endo= into the cell (engulf). Exo= out of the cell (excrete). What is active transport? - ANS requires the cell to expend energy (by means of ATP) to move larger molecules and molecular complexes What is pinocytosis? - ANS the ingestion of liquid into a cell by the budding of small vesicles from the cell membrane. (drinking)