UNE Biochem 1005 Unit 2 exam UPDATED
Questions with CORRECT Answers
1. Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? -
CORRECT ANSWER - The phosphorylation and inactivation of E1 subunit (pyruvate
dehydrogenase complex
1. Which of the following intermediates is an allosteric activator of pyruvate kinase? -
CORRECT ANSWER - a. Fructose 1.6 bisphosphate
1. Which of the following is the initial second messenger in the signaling cascade initiated by
glucagon? - CORRECT ANSWER - a. cAMP
1. Hereditary fructose intolerance in caused by a deficiency in aldolase B. These individuals may
present with hypoglycemia due to an accumulation of fructose 1-P in the cell and inhibition of
which of the following pathways? - CORRECT ANSWER - a. Gluconeogenesis and
glycogenolysis
1. Following insulin binding its receptor and autophosphorylation of the beta chain, what is the
initial step in the cascade of events? - CORRECT ANSWER - a. Recruitment of the insulin
receptor substrate
1. What sequence of enzymes allows for the synthesis of glycogen from glucose 6-P? -
CORRECT ANSWER - Phosphoglucomutase, UDP-glucose phosphorylase, glycogen
synthase amylo-(1,4a1,6)-transglycosylase
1. Complex II, succinate dehydrogenase, is not considered to be part of the process of oxidative
phosphorylation because it is unable to do which of the following activities? - CORRECT
ANSWER - a. Pump protons from the mitochondrial matrix to the intermembrane space
1. Which of the following is the primary GLUT transporter in skeletal muscle and adipose
tissue? - CORRECT ANSWER - GLUT 4
,1. Which of the following best describes the net effect of the 8 steps of the TCA cycle? -
CORRECT ANSWER - a. This process completely oxidizes an acetyl group to carbon
dioxide
1. Which of the following enzymes is correctly paired with this activator? - CORRECT
ANSWER - a. Pyruvate dehydrogenase complex, pyruvate
1. ATP is a high energy molecule that is often hydrolyzed during reactions. The energy within
ATP is stored primarily in which of the following compounds of the molecule? - CORRECT
ANSWER - a. In the high energy phosphate bonds
1. Which of the following is a key inhibitor of the a-ketoglutarate dehydrogenase? - CORRECT
ANSWER - NADH
1. As electrons flow through complexes in the inner mitochondrial membrane, protons are
pumped from the matrix to the intermembrane space. Which of the following statements is most
reflective of the pH in the intermembrane space? - CORRECT ANSWER - a. The pH is
higher in the matrix when compared to the intermembrane space
1. Pyruvate dehydrogenase complex is highly regulated. The enzyme will be most active when
which of the following compounds is high? - CORRECT ANSWER - Pyruvate
1. TCA cycle intermediates are always being removed for various metabolic processes. One
example of this is the removal of succinyl CoA which is used for the synthesis of which of the
following compounds? - CORRECT ANSWER - Heme
1. The fully reduced quinol form of CoQ contains which of the following combinations of
electrons and protons? - CORRECT ANSWER - 2 e- and two protons
1. Individuals with a deficiency in glucose 6-P dehydrogenase often present with hemolytic
anemia. This is primarily due to a deficiency in which of the following metabolic products? -
CORRECT ANSWER - NADPH
, 1. Within the red blood cell, glucose can be oxidized to which of the following products? -
CORRECT ANSWER - lactate and ribose 5- phosphate
1. Which of the following is an inhibitor of isocitrate dehydrogenase and a-ketoglutarate
dehydrogenase? - CORRECT ANSWER - a. NADH
1. The non-oxidative stage of the pentose phosphate pathway produces substances that are
intermediates of ____? - CORRECT ANSWER - Glycolysis
1. The glycerol 3-P shuttle is the major shuttle of most tissues. Which of the following best
describes the transfer of electrons by this shuttle? - CORRECT ANSWER - a. Electrons
are directly transferred from glycerol 3-P to an FAD containing glycerol phosphate
dehydrogenase
1. Glycogen degradation in the liver can be enhanced by the activation of alpha-adrenergic
receptors by epinephrine. The initial step in this cascade involves which of the following second
messengers or active enzymes? - CORRECT ANSWER - a. Phospholipase C
1. Which of the following enzymes is involved in the non-oxidative portion of the pentose
pathway? - CORRECT ANSWER - Transketolase
1. Heme can inhibit its own synthesis by inhibiting the activity of which of the following
enzymes? - CORRECT ANSWER - a. Aminolevulinic acid synthase
1. Under low energy conditions, AMP will bind to phosphofructokinase-1 and glycogen
phosphorylase. This is an example of which of the following types of enzyme regulation? -
CORRECT ANSWER - a. Allosteric activation
1. Activation of glycogen phosphorylase is regulated in several manners. In skeletal muscle,
which of the following compounds can allosterically activate the enzyme? - CORRECT
ANSWER - a. AMP
Questions with CORRECT Answers
1. Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? -
CORRECT ANSWER - The phosphorylation and inactivation of E1 subunit (pyruvate
dehydrogenase complex
1. Which of the following intermediates is an allosteric activator of pyruvate kinase? -
CORRECT ANSWER - a. Fructose 1.6 bisphosphate
1. Which of the following is the initial second messenger in the signaling cascade initiated by
glucagon? - CORRECT ANSWER - a. cAMP
1. Hereditary fructose intolerance in caused by a deficiency in aldolase B. These individuals may
present with hypoglycemia due to an accumulation of fructose 1-P in the cell and inhibition of
which of the following pathways? - CORRECT ANSWER - a. Gluconeogenesis and
glycogenolysis
1. Following insulin binding its receptor and autophosphorylation of the beta chain, what is the
initial step in the cascade of events? - CORRECT ANSWER - a. Recruitment of the insulin
receptor substrate
1. What sequence of enzymes allows for the synthesis of glycogen from glucose 6-P? -
CORRECT ANSWER - Phosphoglucomutase, UDP-glucose phosphorylase, glycogen
synthase amylo-(1,4a1,6)-transglycosylase
1. Complex II, succinate dehydrogenase, is not considered to be part of the process of oxidative
phosphorylation because it is unable to do which of the following activities? - CORRECT
ANSWER - a. Pump protons from the mitochondrial matrix to the intermembrane space
1. Which of the following is the primary GLUT transporter in skeletal muscle and adipose
tissue? - CORRECT ANSWER - GLUT 4
,1. Which of the following best describes the net effect of the 8 steps of the TCA cycle? -
CORRECT ANSWER - a. This process completely oxidizes an acetyl group to carbon
dioxide
1. Which of the following enzymes is correctly paired with this activator? - CORRECT
ANSWER - a. Pyruvate dehydrogenase complex, pyruvate
1. ATP is a high energy molecule that is often hydrolyzed during reactions. The energy within
ATP is stored primarily in which of the following compounds of the molecule? - CORRECT
ANSWER - a. In the high energy phosphate bonds
1. Which of the following is a key inhibitor of the a-ketoglutarate dehydrogenase? - CORRECT
ANSWER - NADH
1. As electrons flow through complexes in the inner mitochondrial membrane, protons are
pumped from the matrix to the intermembrane space. Which of the following statements is most
reflective of the pH in the intermembrane space? - CORRECT ANSWER - a. The pH is
higher in the matrix when compared to the intermembrane space
1. Pyruvate dehydrogenase complex is highly regulated. The enzyme will be most active when
which of the following compounds is high? - CORRECT ANSWER - Pyruvate
1. TCA cycle intermediates are always being removed for various metabolic processes. One
example of this is the removal of succinyl CoA which is used for the synthesis of which of the
following compounds? - CORRECT ANSWER - Heme
1. The fully reduced quinol form of CoQ contains which of the following combinations of
electrons and protons? - CORRECT ANSWER - 2 e- and two protons
1. Individuals with a deficiency in glucose 6-P dehydrogenase often present with hemolytic
anemia. This is primarily due to a deficiency in which of the following metabolic products? -
CORRECT ANSWER - NADPH
, 1. Within the red blood cell, glucose can be oxidized to which of the following products? -
CORRECT ANSWER - lactate and ribose 5- phosphate
1. Which of the following is an inhibitor of isocitrate dehydrogenase and a-ketoglutarate
dehydrogenase? - CORRECT ANSWER - a. NADH
1. The non-oxidative stage of the pentose phosphate pathway produces substances that are
intermediates of ____? - CORRECT ANSWER - Glycolysis
1. The glycerol 3-P shuttle is the major shuttle of most tissues. Which of the following best
describes the transfer of electrons by this shuttle? - CORRECT ANSWER - a. Electrons
are directly transferred from glycerol 3-P to an FAD containing glycerol phosphate
dehydrogenase
1. Glycogen degradation in the liver can be enhanced by the activation of alpha-adrenergic
receptors by epinephrine. The initial step in this cascade involves which of the following second
messengers or active enzymes? - CORRECT ANSWER - a. Phospholipase C
1. Which of the following enzymes is involved in the non-oxidative portion of the pentose
pathway? - CORRECT ANSWER - Transketolase
1. Heme can inhibit its own synthesis by inhibiting the activity of which of the following
enzymes? - CORRECT ANSWER - a. Aminolevulinic acid synthase
1. Under low energy conditions, AMP will bind to phosphofructokinase-1 and glycogen
phosphorylase. This is an example of which of the following types of enzyme regulation? -
CORRECT ANSWER - a. Allosteric activation
1. Activation of glycogen phosphorylase is regulated in several manners. In skeletal muscle,
which of the following compounds can allosterically activate the enzyme? - CORRECT
ANSWER - a. AMP
