PAT401 WK 10 MEDS Exam Questions
With Correct Answers A+
What are indications of use for opioids in sickle cell? - Answer✔pain relief
What opioids are used for sickle cell? - Answer✔morphine and hydromorphone
What are the mechanisms of action for morphine? - Answer✔- activates mu and kappa receptors
in brain and dorsal horn of spinal cord
- mimics endogenous opioids such as endorphins and enkephalins (also stimulate opioid
receptors)
What are adverse effects of morphine? - Answer✔- dysphoria (restlessness, depression, anxiety)
- hallucinations
- nausea, constipation
- orthostatic hypotension, dizziness
- pruritus
- respiratory depression, cardiac arrest
What are mechanisms of action for hydromorphone? - Answer✔- inhibits ascending pain
pathways in CNS
- increases pain threshold
- alters pain perception
What are adverse effects of hydromorphone? - Answer✔- life-threatening respiratory depression!
- hypotension
- drowsiness, dizziness, confusion
- pruritus
- nausea, constipation
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