Antigen and Antibody MCQ Questions and Answers

Antigen and Antibody MCQ Questions and Answers The immunoglobulin isotype is determined by which of the following? The Framework region Number of antigen-binding sites L chain variable region H chain constant region Number of VH domains H chain constant region Question 2 1 / 1 pts What process is taking place during the lag period between antigen contact and detection of adaptive immunity? Innate immunity blocks the activation of adaptive immune effector cells. Innate immune effectors are eliminating antigen. New B and T cells with the appropriate antigen specificity must be produced in the bone marrow. Cellular immunity can be detected but antibodies cannot. Antigen is hidden from the immune system in macrophages. Innate immune effectors are eliminating antigen. Question 3 1 / 1 pts If V(D)J recombination events cannot take place due to the absence of RAG1 and/or RAG2 genes, which of the following cells would be most affected? B cells and T cells Plasma cells and dendritic cells NK cells and macrophages M cells and Paneth cells Eosinophils and mast cells B cells and T cells Question 4 1 / 1 pts Antibody-dependent cell-mediated cytotoxicity (ADCC) is a process in which antibody-coated cells are killed by Cytotoxic T cells. Cells with Fc receptors for IgG3. Cells with Fc receptors for IgE. Antibody Complement Cells with Fc receptors for IgG3. Question 5 1 / 1 pts When do lymphocytes acquire their antigen specificity? Before they encounter antigen As they enter the tissues from the circulation After contact with self-antigen Upon binding with MHC Following processing in the secondary lymphoid organs Before they encounter antigen Question 6 1 / 1 pts Antibody effector functions include all EXCEPT which of the following? Blocking uptake of bacterial toxins by host cells Binding intracellular viruses to initiate cytotoxicity Coating bacteria to promote their phagocytosis by neutrophils Activating complement on bacterial surfaces to promote phagocytosis by neutrophils Binding extracellular viruses to block their entry into host cells Binding intracellular viruses to initiate cytotoxicity Question 7 1 / 1 pts The gene segments needed to encode the variable region of a λ chain are: one Vλ and one Jλ and one Dλ one Jλ and one Cλ one Vλ and one Jλ one Vλ and one Dλ one Jλ and one Dλ one Vλ and one Jλ Question 8 1 / 1 pts Because of the order of the CH gene segments (Cμ, Cd, Cg3, Cg1, Ce ...) a human B cell which undergoes isotype switching from IgM to IgG1 can never in the future secrete which antibody? IgG2 IgG4 IgE IgG3 IgA IgG3 Question 9 1 / 1 pts Which of the following does NOT contribute to immunoglobulin antigen-binding diversity? Any Vk can be joined to any Jk to encode the light chain V region. Many CH genes are present in the germline DNA. Any L chain can combine with any H chain to form a functional antibody. Random numbers of N nucleotides can be added during somatic recombination. VJL and VDJH joining is imprecise. Many CH genes are present in the germline DNA. Question 10 1 / 1 pts What does the term "MHC restriction" refer to? Inheritance of a limited number of MHC antigens Requirement for antigen to be recognized in association with MHC molecules. Ability of MHC genes to regulate TCR rearrangement. Problems associated with allograft rejection. Requirement for MHC molecules to be bound in order to reject grafts Requirement for antigen to be recognized in association with MHC molecules.