NURS 6015 Exam 5 – GI Questions With Complete
Solutions
What is H.pylori?
A bacteria found in the stomach, can lead to cancer or peptic
ulcers
Can Escape destruction by acids
Factors that lead to Gastric Ulcers
H.pylori
Acid
NSAIDS (inhibits prostaglandins)
smoking
Pepsin
Defense factors for a healthy Gut
Mucus
Bicarbonate
Blood flow
Prostaglandins
Famotidine (Pepcid/Zantac)
Class: Histamine, H2 antagonist (H2RA)
Diarrhea
, Dizziness
Headache
Peak 1-3 hours & Duration is 6-15 hours
Famotidine can slow metabolism of other drug which can lead to
toxicity of these drugs:
Warfarin, Phenytoin, BBs, Alcohol, TCAs, Lidocaine,
Benzodiazepine
Omeprazole (Prilosec)
proton pump inhibitor
Used for peptic ulcers, esophagitis, GERD.
Widely prescribed
Reduces acid by 97% in 2 hours
Effects last 3-5 days
AE - Headache, diarrhea, pneumonia, fractures (Ca
supplements), Rebound acid hypersecretion, C. Diff?
Drug interactions: can reduce potency
Plavix, HIV drugs
Teaching for PPI's (proton pump inhibitors)
Rebound Acid Hypersecretion
Take 30/60 minutes before eating.
Solutions
What is H.pylori?
A bacteria found in the stomach, can lead to cancer or peptic
ulcers
Can Escape destruction by acids
Factors that lead to Gastric Ulcers
H.pylori
Acid
NSAIDS (inhibits prostaglandins)
smoking
Pepsin
Defense factors for a healthy Gut
Mucus
Bicarbonate
Blood flow
Prostaglandins
Famotidine (Pepcid/Zantac)
Class: Histamine, H2 antagonist (H2RA)
Diarrhea
, Dizziness
Headache
Peak 1-3 hours & Duration is 6-15 hours
Famotidine can slow metabolism of other drug which can lead to
toxicity of these drugs:
Warfarin, Phenytoin, BBs, Alcohol, TCAs, Lidocaine,
Benzodiazepine
Omeprazole (Prilosec)
proton pump inhibitor
Used for peptic ulcers, esophagitis, GERD.
Widely prescribed
Reduces acid by 97% in 2 hours
Effects last 3-5 days
AE - Headache, diarrhea, pneumonia, fractures (Ca
supplements), Rebound acid hypersecretion, C. Diff?
Drug interactions: can reduce potency
Plavix, HIV drugs
Teaching for PPI's (proton pump inhibitors)
Rebound Acid Hypersecretion
Take 30/60 minutes before eating.