NCNN EXAM STUDY GUIDE WITH
CORRECT SOLUTION
Semaglutide dosing and indication - ANSWER Wegovy
Weight management, chronic (Wegovy):
Note: For use as an adjunct to diet and exercise in patients with a BMI ≥30 kg/m2, or in
patients with a BMI ≥27 kg/m2 and ≥1 weight-associated comorbidity (eg, hypertension,
dyslipidemia).
SUBQ: consider delaying the increase for an additional 4 weeks:
Week 1 through week 4: 0.25 mg once weekly.
Week 5 through week 8: 0.5 mg once weekly.
Week 9 through week 12: 1 mg once weekly.
Week 13 through week 16: 1.7 mg once weekly.
Week 17 and thereafter (maintenance dosage): 2.4 mg once weekly; if not tolerated,
may temporarily decrease dosage to 1.7 mg once weekly for up to 4 additional weeks,
then increase to 2.4 mg once weekly.
Wegovy missed dose - ANSWER Missed dose should be administered as soon as
possible within 5 days; resume usual schedule thereafter. If >5 days have elapsed, skip
the missed dose and resume administration at the next scheduled weekly dose. If 2 or
more consecutive doses are missed, resume dosing as scheduled;
wegovy administration - ANSWER Administer by SUBQ injection into the abdomen,
thigh, or upper arm at any time of day on the same day each week, with or without food.
Rotate inj site
After removal of the pen cap, the needle will be hidden inside the needle cover. To begin
injection, press the needle cover firmly against the skin. Once injected, continue to
press the device against the skin until the yellow bar has stopped moving. Then, remove
the needle from the skin.
Wegovy side effects - ANSWER new or worse behavior or mood changes like depression
or thoughts of suicide
Rare but serious side effect
Signs of an allergic reaction, like rash; hives; itching; red, swollen, wheezing; tightness
, in the chest or throat; trouble breathing,
GI effects, mainly abdominal pain, constipation, diarrhea, nausea, and vomiting,
wegovy storage - ANSWER Wegovy pen: Store at 2°C to 8°C (36°F to 46°F). If needed,
prior to cap removal, the pen can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days.
Do not freeze; protect from light. discard pen after use (for single use only).
Sacubitril and valsartan indication and dosing - ANSWER entresto
Heart failure with reduced ejection fraction
It is used to lower the risk of death and having to go to the hospital because of heart
failure.
Patients previously taking a moderate to high dose of an ACE inhibitor (eg, >10 mg/day
of enalapril or equivalent) or ARB (eg, >160 mg/day of valsartan or equivalent):
Oral: Initial: Sacubitril 49 mg/valsartan 51 mg BID. Double the dose as tolerated after ~2
to 4 weeks to the target maintenance dose of sacubitril 97 mg/valsartan 103 mg BID.
Patients not take or previously taking a low dose of an ACE inhibitor (eg, ≤10 mg/day of
enalapril or equivalent) or ARB (eg, ≤160 mg/day of valsartan or equivalent):
Oral: Initial: Sacubitril 24 mg/valsartan 26 mg BID. Double the dose as tolerated in ~2- to
4-week intervals to the target maintenance dose of sacubitril 97 mg/valsartan 103 mg
BID.
with or wo food
Entresto side effects - ANSWER cough
rare but serious se
• High potassium levels like a heartbeat that does not feel normal; feeling confused;
feeling weak, lightheaded, or dizzy; feeling like passing out
Signs of an allergic reaction, like rash; hives; itching; red, swollen, wheezing; tightness
in the chest or throat; trouble breathing,
entresto missed dose and storage - ANSWER Take a missed dose as soon as you think
about it.
•If it is close to the time for your next dose, skip the missed dose and go back to your
normal time.
•Do not take 2 doses at the same time or extra doses.
room temp Store at 20°C to 25°C (68°F to 77°F); Protect from moisture
APO-varenicline - ANSWER Smoking cessation: Oral:
CORRECT SOLUTION
Semaglutide dosing and indication - ANSWER Wegovy
Weight management, chronic (Wegovy):
Note: For use as an adjunct to diet and exercise in patients with a BMI ≥30 kg/m2, or in
patients with a BMI ≥27 kg/m2 and ≥1 weight-associated comorbidity (eg, hypertension,
dyslipidemia).
SUBQ: consider delaying the increase for an additional 4 weeks:
Week 1 through week 4: 0.25 mg once weekly.
Week 5 through week 8: 0.5 mg once weekly.
Week 9 through week 12: 1 mg once weekly.
Week 13 through week 16: 1.7 mg once weekly.
Week 17 and thereafter (maintenance dosage): 2.4 mg once weekly; if not tolerated,
may temporarily decrease dosage to 1.7 mg once weekly for up to 4 additional weeks,
then increase to 2.4 mg once weekly.
Wegovy missed dose - ANSWER Missed dose should be administered as soon as
possible within 5 days; resume usual schedule thereafter. If >5 days have elapsed, skip
the missed dose and resume administration at the next scheduled weekly dose. If 2 or
more consecutive doses are missed, resume dosing as scheduled;
wegovy administration - ANSWER Administer by SUBQ injection into the abdomen,
thigh, or upper arm at any time of day on the same day each week, with or without food.
Rotate inj site
After removal of the pen cap, the needle will be hidden inside the needle cover. To begin
injection, press the needle cover firmly against the skin. Once injected, continue to
press the device against the skin until the yellow bar has stopped moving. Then, remove
the needle from the skin.
Wegovy side effects - ANSWER new or worse behavior or mood changes like depression
or thoughts of suicide
Rare but serious side effect
Signs of an allergic reaction, like rash; hives; itching; red, swollen, wheezing; tightness
, in the chest or throat; trouble breathing,
GI effects, mainly abdominal pain, constipation, diarrhea, nausea, and vomiting,
wegovy storage - ANSWER Wegovy pen: Store at 2°C to 8°C (36°F to 46°F). If needed,
prior to cap removal, the pen can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days.
Do not freeze; protect from light. discard pen after use (for single use only).
Sacubitril and valsartan indication and dosing - ANSWER entresto
Heart failure with reduced ejection fraction
It is used to lower the risk of death and having to go to the hospital because of heart
failure.
Patients previously taking a moderate to high dose of an ACE inhibitor (eg, >10 mg/day
of enalapril or equivalent) or ARB (eg, >160 mg/day of valsartan or equivalent):
Oral: Initial: Sacubitril 49 mg/valsartan 51 mg BID. Double the dose as tolerated after ~2
to 4 weeks to the target maintenance dose of sacubitril 97 mg/valsartan 103 mg BID.
Patients not take or previously taking a low dose of an ACE inhibitor (eg, ≤10 mg/day of
enalapril or equivalent) or ARB (eg, ≤160 mg/day of valsartan or equivalent):
Oral: Initial: Sacubitril 24 mg/valsartan 26 mg BID. Double the dose as tolerated in ~2- to
4-week intervals to the target maintenance dose of sacubitril 97 mg/valsartan 103 mg
BID.
with or wo food
Entresto side effects - ANSWER cough
rare but serious se
• High potassium levels like a heartbeat that does not feel normal; feeling confused;
feeling weak, lightheaded, or dizzy; feeling like passing out
Signs of an allergic reaction, like rash; hives; itching; red, swollen, wheezing; tightness
in the chest or throat; trouble breathing,
entresto missed dose and storage - ANSWER Take a missed dose as soon as you think
about it.
•If it is close to the time for your next dose, skip the missed dose and go back to your
normal time.
•Do not take 2 doses at the same time or extra doses.
room temp Store at 20°C to 25°C (68°F to 77°F); Protect from moisture
APO-varenicline - ANSWER Smoking cessation: Oral:
