ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE

ONS CHEMOTHERAPY
IMMUNOTHERAPY CERTIFICATE



3opmajoropphasesopofopcellopdivision:op-opans--Interphase
Mitoticopphase
Cytokinesis

3opstepsopofopinterphase:op-opans--Firstopgrowthopphaseop(G1)
Synthesisopphaseop(Sopphase)
Secondopgrowthopphaseop(G2)

4opphasesopofopmitosis:op-opans--Prophase
Metaphase
Anaphase
Telophase

Innateopimmunity:op-opans--Non-specificopresponse,opeither:
1.opBarrierop(skin,opmucousopmembranes,opfloraopofopskin/gut)
2.opCellularopcomponentsop(phagocytes,opnaturalopkilleropcells,opgranulocytes,opmacroph
ages)

Adaptiveopimmunity:op-opans--
Followsopinnateopimmunityopifopunsuccessful.opMemoryopimmunity,opincluding:
1.opHumoralopimmunityop(productionopofopantibodiesoporopimmunoglobulins)
2.opCellopmediatedopimmunityop(dependentopuponopTopcells)
3.opRegulatoryopTop-
cellsop(preventopautoimmuneopreactionsopandoplimitopinflammatoryopresponses)

Defineopmutationsop-opans--Variationsopinoptheopnucleotideopsequenceopofopaopgene

3opmainopgoalsopofoptreatment:op-opans--Cure
Control
Palliation

Defineopneoadjuvantoptherapyop-opans--
Treatmentopisopgivenopprioroptoopsurgeryoptoopshrinkoptheoptumor

, Defineopadjuvantoptherapyop-opans--
Additionalopcanceroptreatmentopgivenopafteroptheopprimaryoptreatmentoptooploweroptheopris
kopthatoptheopcanceropreoccur

Defineopconditioning/preparativeoptherapyop-opans--
Treatmentsopusedoptoopprepareopaoppatientopforopstemopcelloptransplantation

2optypesopofopconditioningoptherapies:op-opans--Myeloablative
Nonmyeloablative

Defineopdoseopdensityop-opans--Drugopdoseopperopunitopofoptime

Defineopdoseopintensityop-opans--Amountopofopdrugopdeliveredopoveroptime

Howopisoprelativeopdoseopintensityop(RDI)opcalculated?op-opans--
ByopcomparingoptheopdoseopthatoptheoppatientopACTUALLYopreceivedoptooptheopplannedo
pdoseopofoptheopstandardopregimen


Howopdoopalkylatingopagentsopwork?op-opans--
ByopcausingopaopbreakopinoptheopDNAophelixopstrand,opinterferingopwithopDNAopreplication
opandopcausingopcellopdeath


3opsubcategoriesopofopalkylatingopagents:op-opans--1.opNitrogenopmustards
2.opPlatinum-
basedopagentsop(doopnotoppossessopanopalkylopgroupopbutopstilloptermedopalkylatingopage
ntsopasoptheyopworkopsimilarly)
3.opNitrosoureas

Mostopcommonopsubcategoryopofopalkylatingopagents:op-opans--Nitrogenopmustards

Commonopalkylatingopagents:op-opans--Cyclophosphamideop(Cytoxan)
Ifosfamideop(Ifex)
Bendamustineop(Treanda)

Commonopplatinum-basedopagents:op-opans--Cisplatinop(Platinol)
Carboplatinop(Paraplatin)

Whatopisopuniqueopaboutopnitrosoureasopagents?op-opans--Ableoptoopcrossoptheopblood-
brainopbarrier;opcanopbeopeffectiveopinoptreatingopsomeopbrainoptumors

Commonopnitrosoureasopagents:op-opans--Carmustineop(BiCNU)
Lomustineop(CeeNu)
Streptozocinop(Zanosar)

Hypersensitivityopcanopoccuropwithoplateopdosesopof:op-opans--Carboplatin