Biochemistry
Extracellular Matrix & Connective Tissue
Compiled By Simon Mwangi
Edition: 2024/25
, Science | Biochemistry I of V pages
1. The following describes the structure of what biomolecule found in the extracellular matrix: found in
proteoglycans
2. Proteoglycans interact with proteins in the matrix such as collagen and elastin, fibronectin, and laminin.
structural; adhesion, migration
3. Proteoglycans consist of a ___ protein covalently attach to many long, linear chains of _____.
core; glycosaminoglycans
4. Glycosaminoglycans are made of repeating ____ units. These repeating units usually contain a ____ and an
acid. These sugars are frequently sulfated. Therefore they repel each other (due to negative charge) and act as
disaccharide; hexosamine, uronic
5. Proteoglycans occupy a very large space and act as molecular ____. These properties give some flexibility
sieves
6. There are at least seven types of glycosaminoglycans, which differ in the monosaccharides present in their
chondoritin sulfate
dermatan sulfate
heparan
heparan sulfate
hyaluronic acid
keratan sulfate I
keratan sulfate II
7. All glycosaminoglycans except ___ ___ are attached to proteins by covalent linkage to serine or threonine
hyaluronic acid
8. Keratan sulfate I is attached via ____ residues
asparagine
9. Once the protein enters the ER, synthesis of the proteoglycans starts with the attachment of a ___ to serine
sugar
10. ____-sugars are the substrates for proteoglycan synthesis
UDP
11. Specific UDP-sugar ________ are responsible for sequential transfer of monosaccharides from a
glycosyltransferases
12. Sulfate groups are added through N- and O-sulfation, and they occur after the addition of sugars. What
PAPS
3 phosphoadenosine 5
13. Once the synthesis of the proteoglycan is complete, it is secreted and forms the ___ ____
extracellular matrix
Biochemistry 2024/25 Edition
Extracellular Matrix & Connective Tissue
Compiled By Simon Mwangi
Edition: 2024/25
, Science | Biochemistry I of V pages
1. The following describes the structure of what biomolecule found in the extracellular matrix: found in
proteoglycans
2. Proteoglycans interact with proteins in the matrix such as collagen and elastin, fibronectin, and laminin.
structural; adhesion, migration
3. Proteoglycans consist of a ___ protein covalently attach to many long, linear chains of _____.
core; glycosaminoglycans
4. Glycosaminoglycans are made of repeating ____ units. These repeating units usually contain a ____ and an
acid. These sugars are frequently sulfated. Therefore they repel each other (due to negative charge) and act as
disaccharide; hexosamine, uronic
5. Proteoglycans occupy a very large space and act as molecular ____. These properties give some flexibility
sieves
6. There are at least seven types of glycosaminoglycans, which differ in the monosaccharides present in their
chondoritin sulfate
dermatan sulfate
heparan
heparan sulfate
hyaluronic acid
keratan sulfate I
keratan sulfate II
7. All glycosaminoglycans except ___ ___ are attached to proteins by covalent linkage to serine or threonine
hyaluronic acid
8. Keratan sulfate I is attached via ____ residues
asparagine
9. Once the protein enters the ER, synthesis of the proteoglycans starts with the attachment of a ___ to serine
sugar
10. ____-sugars are the substrates for proteoglycan synthesis
UDP
11. Specific UDP-sugar ________ are responsible for sequential transfer of monosaccharides from a
glycosyltransferases
12. Sulfate groups are added through N- and O-sulfation, and they occur after the addition of sugars. What
PAPS
3 phosphoadenosine 5
13. Once the synthesis of the proteoglycan is complete, it is secreted and forms the ___ ____
extracellular matrix
Biochemistry 2024/25 Edition
