Biochemistry-Coagulation cascade

Biochemistry

Coagulation Cascade




Compiled By Simon Mwangi
Edition: 2024/25

, Science | Biochemistry I of VI pages
1. What is hemostasis?
The process of blood clot formation and dissolution

2. What does homeostasis require?
Platelet activation and a cascade of zymogens activation

3. 4 phases of hemostasis
Constriction of blood vesselFormation of a temporary platelet plugActivation of the coagulation

4. Which steps are included in primary hemostasis?
Constriction of blood vesselFormation of a temporary platelet plugActivatio

5. Which step is included in secondary hemostasis?
Activation of the coagulation cascade

6. Which are the smallest cell in the blood?
Platelets

7. Where is the production of platelets?
Bone marrow

8. What is endothelin released by?
The endothelium

9. What layer of the blood vessel is destroyed during injury?
The endothelium layer

10. What causes platelet activation?
Collagen and basement membran exposure to blood

11. What does endothelin release cause?
Vasoconstriction

12. What are some of the signalling molecules released by platelets?
Thromboxanes

13. What allows adhesion of platelets to collagen?
Membran proteins like GPIb, GPIIB and GPIIIa

14. What is the coagulation cascade?
A series of reactions catalysed by protein enzymes known as coagulation factors

15. Why is blood coagulation a cascade?
A small trigger can have a bigger impactIt is very sensitive and effective

16. Is blood coagulation cascade regulated?
Yes highlyThere are inhibitors which help with regulation


Biochemistry 2024/25 Edition