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CSUSM Spring '26, NURS 316, Exam 1
Study online at https://quizlet.com/_iwio0h
1. What does ADME Absorption, Distribution, Metabolism, Excretion
stand for in phar-
macokinetics?
2. What is absorption The passage of a drug from the site of administration into the bloodstream
in pharmacokinet-
ics?
3. What is the The reduction in drug concentration before it reaches systemic circulation when
first-pass effect? oral medications pass through the liver first
4. What is distribu- The transport of a drug by the bloodstream from the site of absorption to the
tion in pharmaco- site of action
kinetics?
5. What is metabo- The chemical alteration of drugs in the body to facilitate elimination
lism in pharmaco-
kinetics?
6. What is excretion The elimination of drugs from the body
in pharmacokinet-
ics?
7. What is the The time required for half (50%) of a given drug to be removed from the body
half-life of a drug?
8. After how many Approximately five half-lives
half-lives is a
drug considered ef-
fectively removed
from the body?
9.
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CSUSM Spring '26, NURS 316, Exam 1
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What is steady The physiologic state in which the amount of drug removed via elimination
state in pharmaco- equals the amount absorbed with each dose
kinetics?
10. Why does the Because liver metabolism inactivates a portion of the drug before it reaches
first-pass effect systemic circulation
lower oral bioavail-
ability?
11. Why might high- Because a portion of the drug is metabolized by the liver before reaching
er oral doses systemic circulation, reducing bioavailability
be needed for
drugs with signif-
icant first-pass ef-
fect?
12. Why is nitro- Because it undergoes extensive first-pass metabolism in the liver
glycerin ineffective
when given orally?
13. What is a poten- May postpone effective treatment of chronic disease states
tial hazard of OTC
drug use related to
chronic disease?
14. What is a poten- May delay treatment of serious or life-threatening disorders
tial hazard of OTC
drug use related to
serious illness?
15. What is a poten- May relieve symptoms of a disorder but not treat the underlying cause
tial hazard of OTC
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CSUSM Spring '26, NURS 316, Exam 1
Study online at https://quizlet.com/_iwio0h
drug use related to
symptom relief?
16. What toxicity risk OTC drugs can cause toxicity if misused or taken in excess
exists with OTC
drugs?
17. What interaction Interactions with current prescription medications may occur
risk exists with
OTC drugs?
18. What abuse risk Some OTC drugs have potential for abuse or dependence
exists with OTC
drugs?
19. What is tonicity? The amount of solutes in a solution compared with the bloodstream
20. What is an isotonic A solution with the same tonicity as blood that does not cause fluid shifts or
solution? changes in cell size
21. What is the 0.9% sodium chloride (normal saline)
standard isotonic
saline solution?
22. What is Ringer's An isotonic solution with physiological constituents similar to those found in
lactate solution? blood
23. What is a hypoton- A solution with fewer particles (more water) than blood
ic solution?
24. What happens It causes fluid to shift from the extracellular fluid into the intracellular fluid
when a hypotonic
solution is infused
intravenously?
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CSUSM Spring ’26 NURS
316 Exam 1 Practice
Questions and Answers |
Nursing Exam Prep
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CSUSM Spring '26, NURS 316, Exam 1
Study online at https://quizlet.com/_iwio0h
1. What does ADME Absorption, Distribution, Metabolism, Excretion
stand for in phar-
macokinetics?
2. What is absorption The passage of a drug from the site of administration into the bloodstream
in pharmacokinet-
ics?
3. What is the The reduction in drug concentration before it reaches systemic circulation when
first-pass effect? oral medications pass through the liver first
4. What is distribu- The transport of a drug by the bloodstream from the site of absorption to the
tion in pharmaco- site of action
kinetics?
5. What is metabo- The chemical alteration of drugs in the body to facilitate elimination
lism in pharmaco-
kinetics?
6. What is excretion The elimination of drugs from the body
in pharmacokinet-
ics?
7. What is the The time required for half (50%) of a given drug to be removed from the body
half-life of a drug?
8. After how many Approximately five half-lives
half-lives is a
drug considered ef-
fectively removed
from the body?
9.
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CSUSM Spring '26, NURS 316, Exam 1
Study online at https://quizlet.com/_iwio0h
What is steady The physiologic state in which the amount of drug removed via elimination
state in pharmaco- equals the amount absorbed with each dose
kinetics?
10. Why does the Because liver metabolism inactivates a portion of the drug before it reaches
first-pass effect systemic circulation
lower oral bioavail-
ability?
11. Why might high- Because a portion of the drug is metabolized by the liver before reaching
er oral doses systemic circulation, reducing bioavailability
be needed for
drugs with signif-
icant first-pass ef-
fect?
12. Why is nitro- Because it undergoes extensive first-pass metabolism in the liver
glycerin ineffective
when given orally?
13. What is a poten- May postpone effective treatment of chronic disease states
tial hazard of OTC
drug use related to
chronic disease?
14. What is a poten- May delay treatment of serious or life-threatening disorders
tial hazard of OTC
drug use related to
serious illness?
15. What is a poten- May relieve symptoms of a disorder but not treat the underlying cause
tial hazard of OTC
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CSUSM Spring '26, NURS 316, Exam 1
Study online at https://quizlet.com/_iwio0h
drug use related to
symptom relief?
16. What toxicity risk OTC drugs can cause toxicity if misused or taken in excess
exists with OTC
drugs?
17. What interaction Interactions with current prescription medications may occur
risk exists with
OTC drugs?
18. What abuse risk Some OTC drugs have potential for abuse or dependence
exists with OTC
drugs?
19. What is tonicity? The amount of solutes in a solution compared with the bloodstream
20. What is an isotonic A solution with the same tonicity as blood that does not cause fluid shifts or
solution? changes in cell size
21. What is the 0.9% sodium chloride (normal saline)
standard isotonic
saline solution?
22. What is Ringer's An isotonic solution with physiological constituents similar to those found in
lactate solution? blood
23. What is a hypoton- A solution with fewer particles (more water) than blood
ic solution?
24. What happens It causes fluid to shift from the extracellular fluid into the intracellular fluid
when a hypotonic
solution is infused
intravenously?
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