ATI PHARMACOLOGY TEST BANK ACTUAL EXAM 350
QUESTIONS AND CORRECT ANSWERS 2024-2025
LATEST//ALREADY GRADED A+
Phenoxybenzamine is a nonselective, noncompetitive blocker of a1 and a2 adrenergic receptors. This
means that phenoxybenzamine - ANSWER-blocks the activation of a adrenergic receptors and prevents
the function of endogenous and exogenous ligands e.g. norepinephrine
What is the mechanism of action of atropine? - ANSWER-binds to muscarinic receptors and
competitively prevents acetylcholine from binding
An indirect agonist will - ANSWER-enhance the release of norepinephrine from vesicles
Why is propranolol contradicted in patients with COPD or asthma? - ANSWER-it causes significant
bronchoconstriction due to its blockade of the B2 receptor
Which fo the following is responsible for the peripheral nervous system innervation at the skeletal
muscle? - ANSWER-somatic system
Which of the following explains why physostigmine is useful in treating the symptoms of myasthenia
gravis? - ANSWER-physostigmine inhibits acetylcholinesterase and increases acetylcholine levels at the
synaptic cleft
Which of the following agents is best suited to treat pregnancy-induced hypertension? -
ANSWERlabetalol
A patient enters the emergency room with bradycardia and hypotension. He reports eating Amanita
muscaria mushrooms, a species known to contain muscarine. What is the best drug to use as an
antidote? - ANSWER-atropine
Neuromuscular blocking drugs, such as ciastricurium and tubocurarine, function by -
ANSWERcompetitively blocking acetylcholine by binding to nicotine receptors in the neuromuscular
junction Higher affinity to B adrenergic receptors is found with compounds that have - ANSWER-larger
substituents on the amine nitrogen
,A patient with Alzheimer disease needs treatment for overactive bladder. Which drug is the best choice
for this patient? - ANSWER-trospium
What is the main clinic use for mirabegron, an agonist at the B3-adrenoceptor? - ANSWER-treatment of
overactive bladder
A 40-year old man presents to his family physician with drooping eyelids, difficulty chewing and
swallowing, and muscle fatigue even on mild exertion. Which agent could be used to diagnose
myasthenia gravis in this patient? - ANSWER-edrophonium
What is the main clinical use for agonists at the B2-adrenoceptor? - ANSWER-treatment of asthma
A 23-year old male college student is taking amphetamine on a regular basis to stay alert while studying.
The mechanism of action of amphetamine that causes this effect is: - ANSWER-due to the release of
norepinephrine from central adrenergic neurons
What is the predominant adrenoceptor in heart muscles? - ANSWER-B1-adrenoceptor
Which enzyme is responsible for the deactivation of norepinephrine through the oxidation of the amine?
- ANSWER-monoamine oxidase (MAO)
Which of the following is a natural chemical messenger for the adrenergic receptor? -
ANSWERnorepinephrine
What are the two main adrenergic receptors? - ANSWER-alpha and beta
What is the benefit of salmeterol over other B2-adrenoceptor agonists such as terbutaline? -
ANSWERlonger lasting duration of action, fewer doses throughout the day
A 32-year old women with the diagnosis of pheochromocytoma is scheduled for surgery to remove her
adrenal tumor. The best drug to control her episodes of high blood pressure prior to her surgery would
be - ANSWER-a nonselective a adrenergic antagonist such as phenoxybenzamine
, Which of the following explains why a patient might experience muscle soreness after the use of
succinylcholine for surgery - ANSWER-succinylcholine causes a brief muscle twitch and initial
depolarization
A 23-year old man is accosted by 3 men late at night. Immediately his heart rate increases due to an
increase in epinephrine in his circulation. The release of epinephrine from the adrenal medulla is the
result of the action of acetylcholine on - ANSWER-nicotine receptors
A 65-year old men with the diagnosis of Alzheimer's disease is being treated with donepezil. This drug
acts by - ANSWER-inhibiting acetylcholinesterase
A patient on a diagnostic test for myasthenia gravis would be expected to have improved neuromuscular
function after being treated with with - ANSWER-edrophonium
Which of the following enzymes catalyzes the rate-limiting step in the synthesis of norepinephrine,
responsible for the conversion of tyramine to L-DOPA - ANSWER-tyrosine hydroxylase
A 23-year old man has deliberately ingested an organophosphate insecticide. His initial symptoms of
salivation, lacrimation, and diarrhea are a consequence of - ANSWER-inhibition of acetylcholinesterase
Due to its shorter duration of action, this drug is used as ophthalmic solutions for mydriasis and
cycloplegia - ANSWER-tropicamide
Which of the following is useful in treating hypertension and minimizing withdrawal symptoms from
opiates? - ANSWER-clonidine
A 72-year old patient is seeking treatment for chronic open-angle glaucoma, what drug would you
recommend? - ANSWER-timolol
The characterization of the B adrenergic receptors is based on the strong response to -
ANSWERisoproterenol
QUESTIONS AND CORRECT ANSWERS 2024-2025
LATEST//ALREADY GRADED A+
Phenoxybenzamine is a nonselective, noncompetitive blocker of a1 and a2 adrenergic receptors. This
means that phenoxybenzamine - ANSWER-blocks the activation of a adrenergic receptors and prevents
the function of endogenous and exogenous ligands e.g. norepinephrine
What is the mechanism of action of atropine? - ANSWER-binds to muscarinic receptors and
competitively prevents acetylcholine from binding
An indirect agonist will - ANSWER-enhance the release of norepinephrine from vesicles
Why is propranolol contradicted in patients with COPD or asthma? - ANSWER-it causes significant
bronchoconstriction due to its blockade of the B2 receptor
Which fo the following is responsible for the peripheral nervous system innervation at the skeletal
muscle? - ANSWER-somatic system
Which of the following explains why physostigmine is useful in treating the symptoms of myasthenia
gravis? - ANSWER-physostigmine inhibits acetylcholinesterase and increases acetylcholine levels at the
synaptic cleft
Which of the following agents is best suited to treat pregnancy-induced hypertension? -
ANSWERlabetalol
A patient enters the emergency room with bradycardia and hypotension. He reports eating Amanita
muscaria mushrooms, a species known to contain muscarine. What is the best drug to use as an
antidote? - ANSWER-atropine
Neuromuscular blocking drugs, such as ciastricurium and tubocurarine, function by -
ANSWERcompetitively blocking acetylcholine by binding to nicotine receptors in the neuromuscular
junction Higher affinity to B adrenergic receptors is found with compounds that have - ANSWER-larger
substituents on the amine nitrogen
,A patient with Alzheimer disease needs treatment for overactive bladder. Which drug is the best choice
for this patient? - ANSWER-trospium
What is the main clinic use for mirabegron, an agonist at the B3-adrenoceptor? - ANSWER-treatment of
overactive bladder
A 40-year old man presents to his family physician with drooping eyelids, difficulty chewing and
swallowing, and muscle fatigue even on mild exertion. Which agent could be used to diagnose
myasthenia gravis in this patient? - ANSWER-edrophonium
What is the main clinical use for agonists at the B2-adrenoceptor? - ANSWER-treatment of asthma
A 23-year old male college student is taking amphetamine on a regular basis to stay alert while studying.
The mechanism of action of amphetamine that causes this effect is: - ANSWER-due to the release of
norepinephrine from central adrenergic neurons
What is the predominant adrenoceptor in heart muscles? - ANSWER-B1-adrenoceptor
Which enzyme is responsible for the deactivation of norepinephrine through the oxidation of the amine?
- ANSWER-monoamine oxidase (MAO)
Which of the following is a natural chemical messenger for the adrenergic receptor? -
ANSWERnorepinephrine
What are the two main adrenergic receptors? - ANSWER-alpha and beta
What is the benefit of salmeterol over other B2-adrenoceptor agonists such as terbutaline? -
ANSWERlonger lasting duration of action, fewer doses throughout the day
A 32-year old women with the diagnosis of pheochromocytoma is scheduled for surgery to remove her
adrenal tumor. The best drug to control her episodes of high blood pressure prior to her surgery would
be - ANSWER-a nonselective a adrenergic antagonist such as phenoxybenzamine
, Which of the following explains why a patient might experience muscle soreness after the use of
succinylcholine for surgery - ANSWER-succinylcholine causes a brief muscle twitch and initial
depolarization
A 23-year old man is accosted by 3 men late at night. Immediately his heart rate increases due to an
increase in epinephrine in his circulation. The release of epinephrine from the adrenal medulla is the
result of the action of acetylcholine on - ANSWER-nicotine receptors
A 65-year old men with the diagnosis of Alzheimer's disease is being treated with donepezil. This drug
acts by - ANSWER-inhibiting acetylcholinesterase
A patient on a diagnostic test for myasthenia gravis would be expected to have improved neuromuscular
function after being treated with with - ANSWER-edrophonium
Which of the following enzymes catalyzes the rate-limiting step in the synthesis of norepinephrine,
responsible for the conversion of tyramine to L-DOPA - ANSWER-tyrosine hydroxylase
A 23-year old man has deliberately ingested an organophosphate insecticide. His initial symptoms of
salivation, lacrimation, and diarrhea are a consequence of - ANSWER-inhibition of acetylcholinesterase
Due to its shorter duration of action, this drug is used as ophthalmic solutions for mydriasis and
cycloplegia - ANSWER-tropicamide
Which of the following is useful in treating hypertension and minimizing withdrawal symptoms from
opiates? - ANSWER-clonidine
A 72-year old patient is seeking treatment for chronic open-angle glaucoma, what drug would you
recommend? - ANSWER-timolol
The characterization of the B adrenergic receptors is based on the strong response to -
ANSWERisoproterenol
