ATI PHARMACOLOGY NURS 7430 REAL EXAM QUESTIONS AND VERIFIED ANSWERS 2024
LATEST//GRADED A+
Name the following concepts involved in active transport of drugs
- answer--Consumption of Energy
-Specific Carrier
-Saturable
"Passive diffusion is driven by concentration gradient. Active CARRIER transport requires energy and a
specific carrier which can be saturated if too much medication is available"
What is the predominant issue that impacts drug effectiveness and safety with regard to
pharmacokinetics in the elderly? - answer-decreased renal functioning
"remember - pharmacokinetics is what the BODY does to the drug, thus decreased renal function is the
right answer!"
Which schedule of drugs is described as "A drug used in medical treatment with high abuse potential
and may result in physical and mental dependence liability." - answer-Schedule II
"Schedule 1 drugs aren't used in medical treatment (except of course, now marijuana is used in the
states where it is legal) BUT the best answer is schedule 2"
What type of drugs can cross the blood-brain barrier (BBB)? - answer-Small and lipid soluble
"The BBB has tight barriers so the molecules must be small. Also lipid soluble drugs cross cell
membranes whereas water soluble drugs aren't able to cross the membrane"
Which statement describes the effects of the presence of liver disease on drug half-life and plasma
protein binding? - answer--Drug half-life would be prolonged and plasma protein binding would
decrease.
, "The liver produces albumin. Albumin is a MAJOR protein that drugs bind to after absorption. Therefore
there is less plasma protein binding because there is less albumin
Less binding sites will increase volume of distribution, slow metabolism (increase half life) because there
is more free drug to metabolize AND because the liver is unable to express the CYP 450 enzymes for
metabolism"
Which of the following is TRUE regarding "first pass" elimination? - answer--drug is first transported
across the gut wall into the portal circulation
-sometimes extensive drug metabolism may occur in the liver
-first-pass effects may reduce drug bioavailability
Which of the following best describes or defines the efficacy of a drug? - answer-Maximal response
produced by a drug
"Efficacy is how well the drug works - POTENCY is the amount of response / dosage."
If a drug with a 2-hour half life is given with an initial dose of 8 mcg/ml, assuming first-order kinetics,
how much drug will be left at 6 hours? - answer-1 mcg. ml
"At 2 hours - 4 mg is left,
At 4 hrs. - 2 mg is left
At 6 hours - 1 mg is left"
Which of the following describes an agonist? - answer-A drug that binds to a receptor and stimulates
cellular activity
"an agonist binds to a cell and leads to cellular activity. An antagonist inhibits cellular activity"
LATEST//GRADED A+
Name the following concepts involved in active transport of drugs
- answer--Consumption of Energy
-Specific Carrier
-Saturable
"Passive diffusion is driven by concentration gradient. Active CARRIER transport requires energy and a
specific carrier which can be saturated if too much medication is available"
What is the predominant issue that impacts drug effectiveness and safety with regard to
pharmacokinetics in the elderly? - answer-decreased renal functioning
"remember - pharmacokinetics is what the BODY does to the drug, thus decreased renal function is the
right answer!"
Which schedule of drugs is described as "A drug used in medical treatment with high abuse potential
and may result in physical and mental dependence liability." - answer-Schedule II
"Schedule 1 drugs aren't used in medical treatment (except of course, now marijuana is used in the
states where it is legal) BUT the best answer is schedule 2"
What type of drugs can cross the blood-brain barrier (BBB)? - answer-Small and lipid soluble
"The BBB has tight barriers so the molecules must be small. Also lipid soluble drugs cross cell
membranes whereas water soluble drugs aren't able to cross the membrane"
Which statement describes the effects of the presence of liver disease on drug half-life and plasma
protein binding? - answer--Drug half-life would be prolonged and plasma protein binding would
decrease.
, "The liver produces albumin. Albumin is a MAJOR protein that drugs bind to after absorption. Therefore
there is less plasma protein binding because there is less albumin
Less binding sites will increase volume of distribution, slow metabolism (increase half life) because there
is more free drug to metabolize AND because the liver is unable to express the CYP 450 enzymes for
metabolism"
Which of the following is TRUE regarding "first pass" elimination? - answer--drug is first transported
across the gut wall into the portal circulation
-sometimes extensive drug metabolism may occur in the liver
-first-pass effects may reduce drug bioavailability
Which of the following best describes or defines the efficacy of a drug? - answer-Maximal response
produced by a drug
"Efficacy is how well the drug works - POTENCY is the amount of response / dosage."
If a drug with a 2-hour half life is given with an initial dose of 8 mcg/ml, assuming first-order kinetics,
how much drug will be left at 6 hours? - answer-1 mcg. ml
"At 2 hours - 4 mg is left,
At 4 hrs. - 2 mg is left
At 6 hours - 1 mg is left"
Which of the following describes an agonist? - answer-A drug that binds to a receptor and stimulates
cellular activity
"an agonist binds to a cell and leads to cellular activity. An antagonist inhibits cellular activity"
