Cancer Pharmacology Exam Questions and Correct Answers Latest Update 2024 (Rated A+)

Cancer Pharmacology Exam Questions and Correct Answers Latest Update 2024 (Rated A+) Antimetabolites (S-Phase) (3) - Answers Methotrexate 5-FU Cytarabine Topo II Inhibitors (S-Phase) (2) - Answers Etoposide Teniposide Microtubule Targeting Classes (2) - Answers Vinka Alkaloids Taxoids Vinka Alkaloids (2) - Answers Vincristine Vinblastine Taxoids (1) - Answers Placlitaxel Methotrexate is an analog of - Answers Folic acid Methotrexate inhibits - Answers Dihydrofolate reductase Methotrexate effect - Answers Retards DNA, RNA and protein synthesis 5-FU blocks - Answers Thymidylate synthase 5-FU additional use - Answers Actinic Keratoses Cytarabine is an analog of what - Answers Cytosine Cytarabine MOA - Answers Stalls DNA synthesis and blocks DNA/RNA polymerases Vinca alkaloids MOA - Answers Inhibit tubulin/prevent spindle formation Taxoids MOA - Answers Stabilize microtubules (no progression to anaphase) Alkylating agent example - Answers Cyclophosphamide Alkylating agents MOA - Answers Cross-links DNA Alkylating agents negative effects (3) - Answers Mutagenic, teratogenic, carcinogenic Platinum compounds examples (2) - Answers Cisplatin Carboplatin Platinum compounds MOA - Answers Cross-linking DNA, blocking replication and transcription Antitumor abx examples (1) - Answers Doxorubicin Antitumor abx MOA (3) - Answers Intercalate DNA, inhibit transcription and induce breakage Doxorubicin negative effects - Answers Cardiotoxicity Topo I inhibitors (2) - Answers Topotecan Irinotecan Topo II inhibitors MOA - Answers DNA ds breaks Topo I inhibitors MOA - Answers DNA ss breaks Estrogen receptor antagonist - Answers Tamoxifen Androgen receptor inhibitor - Answers Enzalutamide Tamoxifen use - Answers Post-menopausal breast cancer Enzalutamide use - Answers Prostate carcinoma What do aromatase inhibitors target - Answers Estrogen pathway Aromatase inhibitor (1) - Answers Letrozole Letrozole MOA - Answers Blocks estrogen production Estrogen receptor downregulator (1) - Answers Fulvestrant Abiraterone MOA - Answers Inhibits androgen production Abiraterone use - Answers Castration-resistant prostate cancer All-tran retinoic acid treats (ATRA) [and important gene fusion] - Answers Acute promyelocytic leukemia (PML-RAR-A fusion) ATRA MOA - Answers Induces differentiation of immature granulocytes What drugs end in "-nib" - Answers Kinase inhibitors What drugs end in "-mab" - Answers Antibodies Imatinib targets (3) - Answers ABL, KIT, PDGF receptor Imatinib uses (2) - Answers Chronic myeloid leukemia (ABL) and GIST (KIT) Tyrosine Kinase inhibitor classes (4) - Answers Imatinib HER2 inhibitors EGFR inhibitors Bevacizumab What is HER2 overexpressed in - Answers Breast cancer HER2 Inhibitors (3) - Answers Trastuzumab Ado-trastuzumab Emtansine Lapatinib Trastuzumab MOA - Answers Anti-HER2 antibody Ado-Trastuzumab Emtansine MOA - Answers Anti-HER2 antibody w/ microtubule poison Lapatinib MOA - Answers HER2 Kinase inhibitor EGFR inhibitors (3) - Answers Erlotinib Gefitonib Cetuximab Erlotinib and Gefitonib are used for - Answers NSCLC (Tyrosine kinase inhibitors) Cetuximab uses (2) - Answers Squamous cell carcinoma Colon cancer Bevacizumab MOA - Answers Sequesters VEGF; Inhibits angiogenesis Bevacizumab uses (2) - Answers Metastatic colorectal cancer NSCLC Cell-cycle specific classes (3) - Answers Antimetabolites Topo II Inhibitors Microtubule targeting drugs Cell-cycle non-specific classes (4) - Answers Alkylating agents Platinum compounds Antitumor abx