Defined by 2 characteristics - Answers 1. uncontrolled proliferation
2. metasteses
Hypertrophy - Answers Increase in cell size, normal organization, readily reversible. Muscles.
Hyperplasia - Answers Increase in cell number, normal organization, readily reversible. Calluses.
Dysplasia - Answers Disorganized growth, abnormal morphology, can possibly be reversed. Step toward
neoplasia. HPV treatment can reverse dysplasia of cervical cells
Neoplasia - Answers Disorganized growth, abnormal morphology, net increase in number of
dividing/undifferentiated cells.
Neoplasia characteristics - Answers 1. Cells proliferate in an uncontrolled and mostly autonomous
fashion
2. Result in neoplasm or malignant tumor
3. Could either be that the tumor cells are growing faster than normal cells or that the relationship
between cell division and differentiation are changing
Benign tumors - Answers Localized, closely resemble and possibly function like normal cells
1. Delineated by a fibrous capsule keeping tumor in one location
2. Problems due to bulk
3. Limited destructiveness
Benign characteristics - Answers Nuclear size: small
Nuclear to cytoplasm ratio: small
Nuclear shape: regular
Mitotic index: low
Tissue organization: Normal
Differentiation: well differentiated
Tumor boundary: well define, encapsulated
Malignant tumors - Answers Invade surrounding normal tissue and spread to distant body sites. Higher
rate of division, metastasis, eventually kills host