MCB4271 - Exam 1 Study
Guide
cycloserine - ANSWER 5-membered ring, amide containing
Oxazolidinones structure - ANSWER has a F
Both metronidazole and isoniazid...
A) are prodrugs
B) are commonly used antituberculosis drugs
C) inhibit 50S ribosomal subunit
D) irreversibly and covalently bind to DNA
E) none of the above - ANSWER A
Carbapenems - ANSWER 5 membered ring attached to beta lactam
Methicillin structure - ANSWER -OCH3 (x2)
Monobactams - ANSWER single 4-membered ring
Tetracycline structure - ANSWER 4 6-membered rings structure
Amoxicillin structure - ANSWER -OH
Chloramphenicol structure - ANSWER has a nitro group
macrolides structure - ANSWER lactone structure
6 membered ring containing oxygens
Rifampin structure contains - ANSWER two aromatic rings in the middle and an aliphatic
chain
clavams - ANSWER O-containing 5 membered ring attached to beta-lactam
quinolones - ANSWER look for the F
cephalosporins - ANSWER 6-membered ring attached to beta lactam ring
S at top
lipopeptides structure - ANSWER
, Teixobactin MoA - ANSWER binds to highly conserved part of Lipid II and Lipid III, *not in
clinical trials yet*
glycopeptides structure contains _____, an example is ______ - ANSWER
Penicillin V structure - ANSWER -CH2-O
Ampicillin structure - ANSWER -CHNH2
Streptogramins structure - ANSWER
Fosfomycin structure - ANSWER epoxide with phosphate and methyl
Penicillin G structure - ANSWER -CH2
Discovery of antimicrobial property of penicillium mold was made by - ANSWER Ernest
Duchesne
The "rediscovery" of Penicillin was made by ______ in what year? - ANSWER Alexander
Fleming in 1928
The first clinical use of penicillin was accomplished by - ANSWER Cecil George Paine
Making note of prior clinical use of penicillin, ________ began his studies into the field -
ANSWER Howard Florey
Ernst Chain is best known for - ANSWER the purification of penicillin from Penicillium
mold
In 1940, both _______ and _______ published work stating "Penicillin as a
chemotheraputic agent" - ANSWER Howard Florey and Ernst Chain
In 1943, ______ became commercialized and touted as the "miracle drug" - ANSWER
penicillin
In 1945, which 3 scientists won a Nobel Prize for their work on penicillin? - ANSWER
Florey, Chain and Fleming
A microbial product that kills or inhibits the growth of other microbes - ANSWER
antibiotics
Selman Waksman was most known for - ANSWER his discoveries of numerous and the
most antibiotics
"Father of Antibiotics"
A bacteriocidal agent - ANSWER kills bacteria
A bacteriostatic agent - ANSWER inhibits growth of bacteria
T/F: Antibiotics are not developed, they are discovered - ANSWER T
Guide
cycloserine - ANSWER 5-membered ring, amide containing
Oxazolidinones structure - ANSWER has a F
Both metronidazole and isoniazid...
A) are prodrugs
B) are commonly used antituberculosis drugs
C) inhibit 50S ribosomal subunit
D) irreversibly and covalently bind to DNA
E) none of the above - ANSWER A
Carbapenems - ANSWER 5 membered ring attached to beta lactam
Methicillin structure - ANSWER -OCH3 (x2)
Monobactams - ANSWER single 4-membered ring
Tetracycline structure - ANSWER 4 6-membered rings structure
Amoxicillin structure - ANSWER -OH
Chloramphenicol structure - ANSWER has a nitro group
macrolides structure - ANSWER lactone structure
6 membered ring containing oxygens
Rifampin structure contains - ANSWER two aromatic rings in the middle and an aliphatic
chain
clavams - ANSWER O-containing 5 membered ring attached to beta-lactam
quinolones - ANSWER look for the F
cephalosporins - ANSWER 6-membered ring attached to beta lactam ring
S at top
lipopeptides structure - ANSWER
, Teixobactin MoA - ANSWER binds to highly conserved part of Lipid II and Lipid III, *not in
clinical trials yet*
glycopeptides structure contains _____, an example is ______ - ANSWER
Penicillin V structure - ANSWER -CH2-O
Ampicillin structure - ANSWER -CHNH2
Streptogramins structure - ANSWER
Fosfomycin structure - ANSWER epoxide with phosphate and methyl
Penicillin G structure - ANSWER -CH2
Discovery of antimicrobial property of penicillium mold was made by - ANSWER Ernest
Duchesne
The "rediscovery" of Penicillin was made by ______ in what year? - ANSWER Alexander
Fleming in 1928
The first clinical use of penicillin was accomplished by - ANSWER Cecil George Paine
Making note of prior clinical use of penicillin, ________ began his studies into the field -
ANSWER Howard Florey
Ernst Chain is best known for - ANSWER the purification of penicillin from Penicillium
mold
In 1940, both _______ and _______ published work stating "Penicillin as a
chemotheraputic agent" - ANSWER Howard Florey and Ernst Chain
In 1943, ______ became commercialized and touted as the "miracle drug" - ANSWER
penicillin
In 1945, which 3 scientists won a Nobel Prize for their work on penicillin? - ANSWER
Florey, Chain and Fleming
A microbial product that kills or inhibits the growth of other microbes - ANSWER
antibiotics
Selman Waksman was most known for - ANSWER his discoveries of numerous and the
most antibiotics
"Father of Antibiotics"
A bacteriocidal agent - ANSWER kills bacteria
A bacteriostatic agent - ANSWER inhibits growth of bacteria
T/F: Antibiotics are not developed, they are discovered - ANSWER T
