Conduction Synapses Neuromuscular
Junction
Introduction Nerve conduction
salt ry.co uction.m EPSPELypostsynapticpotential
ffpffgf.tt
fi d9piaiiiiipt imsaberane
Eeaii End
of
itEE iks ieotential
movement
1Neurotransmitterreleasedfrompresynapticneuron
receptive
s egment
Egett cysteine segments've
fiiai gghotejhfianpggffjgs.si
F 2NT
3The
bindstoNTreceptoronthepostsynapticneuron
receptorisactivated causesNat
to
channel
i.NLipYe1fumnY h f1Eh2nerves
gated open
chemically
continuous conduction
4Natfloodsinsidepostsynapticneuron
signal 5thiscauseslocalizeddepolarizationofthe
neuron
ftp.adf
ff IEiftiffffffs E ignaginatedaxons
Glutamate
Presynaptic postsynaptic Et 1 ihh Each
IPSPInhibitorypostsynapticpotential EPPEndplatepotential
Synaptic Transmission typeofEPSPfor a neuromuscularjunction
EfI
ftp.oth it'Thoresen
actionpotential
steps of chemical neurotransmission
Spatial summationvs Temporalsummati
p
neuron
Action arrivesataxon
potential terminal stash memurgyhghiifeushe.in
9 ggreqIedpenfotmhetiefpterminal
voltage 1Neurotransmitterreleasedfrompresynapticneuron
stylible Eltondiff addingsignalsfromsame
synapseovertime
clinicalrelevance paintoall
2NTbindstoNTreceptoronthepostsynapticneuron
ofyourbackhurtsmorethan glinicagarelevance chronic
ho Enn
If f 3Thereceptor isactivated morechannel
io
causes
c ftp.E
as'm Eap isonlyoneparthurt
gs
nffotransmitters
exitFresynapticnerveviaexocytosis iiiii.it iii ii
the
etip
YEepfrss.se tcIert
sIytna
thistriggers
theionctanneccroat.kt.sonci.to
open TIPSEL Effigin
Ioninfluxcausesptstsynapticpotentialon
the2ndneuron
voltagegated vs Neuromuscular Junction
p aᵈ ligandtobe opened
structure Function
n
intilari h.isffintesreceptors junctionbetweenamotorneuron skeletalmusclefibermotorendplate
Neurotransmitterinactivation Steps
1Diffusionoutofsynapticcleft APdown presynapticneurontosynapticknob
2 EnzymaticDestructionexAchesterase goest
ca channelopens cart intothepresynapticneuron'scytosol
3Activetransportex norepinephrine
vesiclesreleaseAdh
viaexocytosis
Drugs e Disorders of the NMMJ Achcrossessynaptic
cleft binds nicotinicreceptor
to
Drugs myasthenia Gravis activationcauses ligandgated channelstoopen
not
type I hypersensitivity localized depolarization ofthemotor
endplate
T.IE qglinekeACh self Abs onAchreceptor
nerveImpulse
blottisleythicked doublevision
Blocktransmission nmg AchTermination cholinergicReceptors achasthenix
require
IyPm worsen w sustained
activity
ÉFÉÉÉiEnÉiÉjÉise
LambertEatonsyndrome
Nqgstiqmiaeipprstim.infohygostigmine
a4jEfo nes
phosphate
DijhEp
selfAbsonpresynapticvoltagegated
ieaeEEhiiywit choline
Effach
acid
acetic
hh
lying.gg
i fgfggjsijrecento
blockAch
esterase fordaysweeks thereforeaesthetic Intagonist atropinep.us
antagoni
iinic
g
Junction
Introduction Nerve conduction
salt ry.co uction.m EPSPELypostsynapticpotential
ffpffgf.tt
fi d9piaiiiiipt imsaberane
Eeaii End
of
itEE iks ieotential
movement
1Neurotransmitterreleasedfrompresynapticneuron
receptive
s egment
Egett cysteine segments've
fiiai gghotejhfianpggffjgs.si
F 2NT
3The
bindstoNTreceptoronthepostsynapticneuron
receptorisactivated causesNat
to
channel
i.NLipYe1fumnY h f1Eh2nerves
gated open
chemically
continuous conduction
4Natfloodsinsidepostsynapticneuron
signal 5thiscauseslocalizeddepolarizationofthe
neuron
ftp.adf
ff IEiftiffffffs E ignaginatedaxons
Glutamate
Presynaptic postsynaptic Et 1 ihh Each
IPSPInhibitorypostsynapticpotential EPPEndplatepotential
Synaptic Transmission typeofEPSPfor a neuromuscularjunction
EfI
ftp.oth it'Thoresen
actionpotential
steps of chemical neurotransmission
Spatial summationvs Temporalsummati
p
neuron
Action arrivesataxon
potential terminal stash memurgyhghiifeushe.in
9 ggreqIedpenfotmhetiefpterminal
voltage 1Neurotransmitterreleasedfrompresynapticneuron
stylible Eltondiff addingsignalsfromsame
synapseovertime
clinicalrelevance paintoall
2NTbindstoNTreceptoronthepostsynapticneuron
ofyourbackhurtsmorethan glinicagarelevance chronic
ho Enn
If f 3Thereceptor isactivated morechannel
io
causes
c ftp.E
as'm Eap isonlyoneparthurt
gs
nffotransmitters
exitFresynapticnerveviaexocytosis iiiii.it iii ii
the
etip
YEepfrss.se tcIert
sIytna
thistriggers
theionctanneccroat.kt.sonci.to
open TIPSEL Effigin
Ioninfluxcausesptstsynapticpotentialon
the2ndneuron
voltagegated vs Neuromuscular Junction
p aᵈ ligandtobe opened
structure Function
n
intilari h.isffintesreceptors junctionbetweenamotorneuron skeletalmusclefibermotorendplate
Neurotransmitterinactivation Steps
1Diffusionoutofsynapticcleft APdown presynapticneurontosynapticknob
2 EnzymaticDestructionexAchesterase goest
ca channelopens cart intothepresynapticneuron'scytosol
3Activetransportex norepinephrine
vesiclesreleaseAdh
viaexocytosis
Drugs e Disorders of the NMMJ Achcrossessynaptic
cleft binds nicotinicreceptor
to
Drugs myasthenia Gravis activationcauses ligandgated channelstoopen
not
type I hypersensitivity localized depolarization ofthemotor
endplate
T.IE qglinekeACh self Abs onAchreceptor
nerveImpulse
blottisleythicked doublevision
Blocktransmission nmg AchTermination cholinergicReceptors achasthenix
require
IyPm worsen w sustained
activity
ÉFÉÉÉiEnÉiÉjÉise
LambertEatonsyndrome
Nqgstiqmiaeipprstim.infohygostigmine
a4jEfo nes
phosphate
DijhEp
selfAbsonpresynapticvoltagegated
ieaeEEhiiywit choline
Effach
acid
acetic
hh
lying.gg
i fgfggjsijrecento
blockAch
esterase fordaysweeks thereforeaesthetic Intagonist atropinep.us
antagoni
iinic
g
