PCOL LEC (prelim exam) PCOL LEC
(prelim exam) 100% Correct Answers
PHARMACOLOGY - correct answer-Study of substances that interact with the living
system through a chemical process
MEDICAL PHARMACOLOGY - correct answer-Science of substances used to prevent,
diagnose, and treat disease
TOXICOLOGY - correct answer-Branch of pharmacology that deals with the
undesirable effects of chemicals on living
system
PHARMACODYNAMICS - correct answer-Action of the Drug on the Body (Drug-
receptor interactions)
PHARMACOKINETICS - correct answer-Action of the Body on the Drug (Absorption,
Distribution, Metabolism, Excretion)
DRUG - correct answer-Any substance that brings a change in biologic function through
its chemical
process
RECEPTORS - correct answer-Component of cell or organism that interacts with drug
leading to an effect
RECEPTOR SITE - correct answer-Specific region of the receptor molecule to which
the drug binds
EFFECTOR - correct answer-Translate the drug-receptor interaction into a change in
cellular activity
EFFICACY - correct answer-Maximal effect drug can produce
POTENCY - correct answer-Amount/concentration of drug required to produce a
specified effect
PREHISTORIC - correct answer-beneficial or toxic effects of many plants and animal
materials
1500 - correct answer-attempts to introduce rational methods to medicine
, 17th century - correct answer-concepts based on observation and experiment
MATERIA MEDICA - correct answer-science of preparation and the medical uses of
drugs
18th, 19th, 20th centuries - correct answer-Experimental physiology and pharmacology
CLINICAL TRIALS
DRUG RECEPTOR - correct answer-was introduced → rapid growth of information and
understanding pf the molecular basis of drug action
CLINICAL TRIALS
ORPHAN RECEPTORS - correct answer-receptors for which no ligand has been
discovered and
whose function can only be guessed
PHARMACOGENOMICS - correct answer-relation of the individual's genetic makeup to
his or her
response to specific drugs
DRUG SIZE - correct answer-Varies in sizes from very small (MW 7 = Li) to very
large(MW 50,000 = thrombolytics)
Most of the drugs MW 100-1000
< 100 → rarely specific, > 1,000 do not diffuse between compartments of the body
DRUG-RECEPTOR BONDS
COVALENT BONDS - correct answer-Very strong (many cases irreversible)
Aspirin (Acetylsalicylic acid)
DRUG-RECEPTOR BONDS
ELECTROSTATIC BONDS - correct answer-Weaker than covalent bonds but stronger
than hydrophobic
Most of drugs
DRUG-RECEPTOR BONDS
HYDROPHOBIC BONDS - correct answer-Weak
Highly lipid soluble drugs and lipids of cell membrane
PHARMACODYNAMIC PRINCIPLES - correct answer-Concerned with receptors,
effectors, dose-response curves, agonist, antagonist, signaling
mechanisms, and receptor regulations
TYPES OF DRUG-RECEPTOR INTERACTIONS
*AGONIST - correct answer-Drugs that binds to and activate the receptors
Affinity + Intrinsic activity
(prelim exam) 100% Correct Answers
PHARMACOLOGY - correct answer-Study of substances that interact with the living
system through a chemical process
MEDICAL PHARMACOLOGY - correct answer-Science of substances used to prevent,
diagnose, and treat disease
TOXICOLOGY - correct answer-Branch of pharmacology that deals with the
undesirable effects of chemicals on living
system
PHARMACODYNAMICS - correct answer-Action of the Drug on the Body (Drug-
receptor interactions)
PHARMACOKINETICS - correct answer-Action of the Body on the Drug (Absorption,
Distribution, Metabolism, Excretion)
DRUG - correct answer-Any substance that brings a change in biologic function through
its chemical
process
RECEPTORS - correct answer-Component of cell or organism that interacts with drug
leading to an effect
RECEPTOR SITE - correct answer-Specific region of the receptor molecule to which
the drug binds
EFFECTOR - correct answer-Translate the drug-receptor interaction into a change in
cellular activity
EFFICACY - correct answer-Maximal effect drug can produce
POTENCY - correct answer-Amount/concentration of drug required to produce a
specified effect
PREHISTORIC - correct answer-beneficial or toxic effects of many plants and animal
materials
1500 - correct answer-attempts to introduce rational methods to medicine
, 17th century - correct answer-concepts based on observation and experiment
MATERIA MEDICA - correct answer-science of preparation and the medical uses of
drugs
18th, 19th, 20th centuries - correct answer-Experimental physiology and pharmacology
CLINICAL TRIALS
DRUG RECEPTOR - correct answer-was introduced → rapid growth of information and
understanding pf the molecular basis of drug action
CLINICAL TRIALS
ORPHAN RECEPTORS - correct answer-receptors for which no ligand has been
discovered and
whose function can only be guessed
PHARMACOGENOMICS - correct answer-relation of the individual's genetic makeup to
his or her
response to specific drugs
DRUG SIZE - correct answer-Varies in sizes from very small (MW 7 = Li) to very
large(MW 50,000 = thrombolytics)
Most of the drugs MW 100-1000
< 100 → rarely specific, > 1,000 do not diffuse between compartments of the body
DRUG-RECEPTOR BONDS
COVALENT BONDS - correct answer-Very strong (many cases irreversible)
Aspirin (Acetylsalicylic acid)
DRUG-RECEPTOR BONDS
ELECTROSTATIC BONDS - correct answer-Weaker than covalent bonds but stronger
than hydrophobic
Most of drugs
DRUG-RECEPTOR BONDS
HYDROPHOBIC BONDS - correct answer-Weak
Highly lipid soluble drugs and lipids of cell membrane
PHARMACODYNAMIC PRINCIPLES - correct answer-Concerned with receptors,
effectors, dose-response curves, agonist, antagonist, signaling
mechanisms, and receptor regulations
TYPES OF DRUG-RECEPTOR INTERACTIONS
*AGONIST - correct answer-Drugs that binds to and activate the receptors
Affinity + Intrinsic activity
