PCOL 406 Exam 1 with Accurate
Solutions
Drug Plasma Concentration - correct answer-how effective the drug is going to be
absorption - correct answer-how it gets from the site of administration into circulation
Distribution - correct answer-how it gets distributed in the body
metabolism - correct answer-how fast is goes through the body(designed to inactivate
and detoxify the drug)
primary organ of metabolism - correct answer-liver
what organ do you want to avoid for the drug to stay active in the body? - correct
answer-liver
what molecular change does metabolism make to drug - correct answer-more
soluble(hydrophilic)
excretion - correct answer-how it leaves the body
primary organ for excretion - correct answer-kidneys(urine)
two things needed for an effect - correct answer-drug and receptor [D-R]
things that affect [D-R] - correct answer-molecule affinity, number of receptors, [C] of
drug
what happens for [D-R] to not come apart - correct answer-a covalent bond is formed
type of bond formed in [D-R] - correct answer-non covalent bonds
parenteral administration - correct answer-drugs that are given by routes other than oral
(beside intestine)
which route of administration has a greater barrier?why? - correct answer-oral, there is
an epithelial barrier in the GI tract and there are tight junctions
routes taken to enter through oral medication - correct answer-1. diffusion
2. transporters
Solutions
Drug Plasma Concentration - correct answer-how effective the drug is going to be
absorption - correct answer-how it gets from the site of administration into circulation
Distribution - correct answer-how it gets distributed in the body
metabolism - correct answer-how fast is goes through the body(designed to inactivate
and detoxify the drug)
primary organ of metabolism - correct answer-liver
what organ do you want to avoid for the drug to stay active in the body? - correct
answer-liver
what molecular change does metabolism make to drug - correct answer-more
soluble(hydrophilic)
excretion - correct answer-how it leaves the body
primary organ for excretion - correct answer-kidneys(urine)
two things needed for an effect - correct answer-drug and receptor [D-R]
things that affect [D-R] - correct answer-molecule affinity, number of receptors, [C] of
drug
what happens for [D-R] to not come apart - correct answer-a covalent bond is formed
type of bond formed in [D-R] - correct answer-non covalent bonds
parenteral administration - correct answer-drugs that are given by routes other than oral
(beside intestine)
which route of administration has a greater barrier?why? - correct answer-oral, there is
an epithelial barrier in the GI tract and there are tight junctions
routes taken to enter through oral medication - correct answer-1. diffusion
2. transporters
