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Final Exam: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana

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Final Exam: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana Q: What is the correct way to take bisphosphonates Answer: On an empty stomach with a full 8 ounces of water Cannot eat or lie down for at least 30-60 minutes after taking Q: Which medication class used to treat osteoporosis can cause severe esophagitis and possible osteonecrosis of the jaw? Answer: Bisphosphonates (-nate) Q: Which medication class used to treat osteoporosis should not be taken by patients with swallowing difficulties or known esophageal abnormalities Answer: Bisphosphonates (-nate) Q: Oral absorption of bisphosphonates is inhibited/blocked by what? Answer: - Food, especially dairy - Calcium supplements (should give these at least an hour after bisphosphonates are taken) Q: How long does it take to see measurable effects on fracture risk with use of bisphosphonates Answer: 6-12 months Q: Pharmacodynamics of the anabolic agent teraperitide (Forteo) in treatment of osteoporosis Answer: This drug is a synthetic, recombinant form of parathyroid hormone (PTH). Like physiologic PTH it stimulates osteoblast activity to form new bone. It also increases absorption of calcium from the G.I. tract and enhances the renal tubular reabsorption of calcium. The net effect is to increase bone density Q: Advantages of using the anabolic agent teraperitide (Forteo) in the treatment of osteoporosis Answer: - Effective in reducing fracture risk in osteoporosis patients who have already suffered a fracture - Provides an option for patients who cannot take other therapies for osteoporosis Q: Disadvantages of using the anabolic agent teraperitide (Forteo) in the treatment of osteoporosis Answer: - Very expensive - Must be injected subcutaneously daily - Limited indications for use - Not recommended for more than 2 years of therapy - Has caused osteosarcoma in laboratory rats; should not be used in patients with Paget's disease of bone Q: Advantages of Acetaminophen in Osteoarthritis Answer: - Does not cause G.I. tract irritations - Does not cause a bleeding tendency like some of the other analgesics used for osteoarthritis - Rapid onset of action (30-60 min.) - Very few contraindications or precautions. Q: Disadvantages of Acetaminophen in Osteoarthritis Answer: - Less potent than aspirin and the other NSAIDs - Has no anti-inflammatory effects outside of the brain; will not reduce peripheral inflammatory conditions - Hepatotoxicity; especially in patients with pre-existing liver disease or with concomitant alcohol intake - Precautions in patients with renal disease; does have some nephrotoxicity if used in excessive doses - Has no anti platelet effects. However, it may increase the anticoagulant effect of warfarin Q: Primary function of the COX-1 enzyme Answer: The COX-1 enzyme is a normally functioning enzyme that continually synthesizes the normal biomediators prostaglandin, prostacyclin, and thromboxane. These biomediators have beneficial normal functions such as gastric mucus production, enhancement of platelet function in blood clotting, vasodilatation (especially of renal arteries), regulation of body temperature, and stimulation of uterine contractions

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FinallExam:lNURS617/lNURSl617l(Latestl
Update)lPharmacotherapeuticslGuide|lQsl&l
As|lGradelA|l100%lCorrectl(Verifiedl
Answers)-lSoutheasternlLouisiana

Q:lWhatlislthelcorrectlwayltoltakelbisphosphonates

Answer:
Onlanlemptylstomachlwithlalfulll8louncesloflwaterl
Cannotleatlorllieldownlforlatlleastl30-60lminuteslafterltaking

Q:lWhichlmedicationlclasslusedltoltreatlosteoporosislcanlcauselseverelesophagitislandlpossibl
elosteonecrosislofltheljaw?

Answer:
Bisphosphonatesl(-nate)

Q:lWhichlmedicationlclasslusedltoltreatlosteoporosislshouldlnotlbeltakenlbylpatientslwithlswa
llowingldifficultieslorlknownlesophageallabnormalities

Answer:
Bisphosphonatesl(-nate)

Q:lOrallabsorptionloflbisphosphonateslislinhibited/blockedlbylwhat?

Answer:

,-lFood,lespeciallyldairy
-lCalciumlsupplementsl(shouldlgiveltheselatlleastlanlhourlafterlbisphosphonateslareltaken)

Q:lHowllongldoeslitltakeltolseelmeasurableleffectslonlfracturelrisklwithluseloflbisphosphonate
s

Answer:
6-12lmonths

Q:lPharmacodynamicsloflthelanaboliclagentlteraperitidel(Forteo)linltreatmentloflosteoporosis

Answer:
Thisldruglislalsynthetic,lrecombinantlformloflparathyroidlhormonel(PTH).lLikelphysiologiclPT
Hlitlstimulateslosteoblastlactivityltolformlnewlbone.lItlalsolincreaseslabsorptionloflcalciumlfro
mlthelG.I.ltractlandlenhanceslthelrenalltubularlreabsorptionloflcalcium.lThelnetleffectlisltolincre
aselboneldensity

Q:lAdvantagesloflusinglthelanaboliclagentlteraperitidel(Forteo)linltheltreatmentloflosteoporosi
s

Answer:
-
lEffectivelinlreducinglfracturelrisklinlosteoporosislpatientslwholhavelalreadylsufferedlalfracture
-lProvideslanloptionlforlpatientslwholcannotltakelotherltherapieslforlosteoporosis

Q:lDisadvantagesloflusinglthelanaboliclagentlteraperitidel(Forteo)linltheltreatmentloflosteopor
osis

Answer:

,-lVerylexpensive
-lMustlbelinjectedlsubcutaneouslyldaily
-lLimitedlindicationslforluse
-lNotlrecommendedlforlmorelthanl2lyearslofltherapy
-
lHaslcausedlosteosarcomalinllaboratorylrats;lshouldlnotlbelusedlinlpatientslwithlPaget'sldiseasel
oflbone

Q:lAdvantagesloflAcetaminophenlinlOsteoarthritis

Answer:
-lDoeslnotlcauselG.I.ltractlirritations
-lDoeslnotlcauselalbleedingltendencyllikelsomeloflthelotherlanalgesicslusedlforlosteoarthritis
-lRapidlonsetloflactionl(30-60lmin.)
-lVerylfewlcontraindicationslorlprecautions.

Q:lDisadvantagesloflAcetaminophenlinlOsteoarthritis

Answer:
-lLesslpotentlthanlaspirinlandlthelotherlNSAIDs
-lHaslnolanti-
inflammatoryleffectsloutsideloflthelbrain;lwilllnotlreducelperipherallinflammatorylconditionsl
-lHepatotoxicity;lespeciallylinlpatientslwithlpre-
existinglliverldiseaselorlwithlconcomitantlalcohollintake
-
lPrecautionslinlpatientslwithlrenalldisease;ldoeslhavelsomelnephrotoxicityliflusedlinlexcessiveld
oses
-lHaslnolantilplateletleffects.lHowever,litlmaylincreaselthelanticoagulantleffectloflwarfarin

Q:lPrimarylfunctionloflthelCOX-1lenzyme

Answer:

, ThelCOX-
1lenzymelislalnormallylfunctioninglenzymelthatlcontinuallylsynthesizeslthelnormallbiomediator
slprostaglandin,lprostacyclin,landlthromboxane.lTheselbiomediatorslhavelbeneficiallnormallfun
ctionslsuchlaslgastriclmucuslproduction,lenhancementloflplateletlfunctionlinlbloodlclotting,lvas
odilatationl(especiallyloflrenallarteries),lregulationloflbodyltemperature,landlstimulationlofluteri
nelcontractions

Q:lPrimarylfunctionloflthelCOX-2lenzyme

Answer:
ThelCOX-
2lenzymelonlylfunctionslduringlstresslorlinflammatorylconditionslandlproduceslthelsamelbiome
diatorslbutlinlgreaterlamountsltolactivatelpainlsensors,lproducelvasodilatation,landlenhancelbloo
dlclottinglinldamagedlbloodlvessels.

Q:lWhichlNSAIDlhaslthelgreatestlanalgesicleffect

Answer:
Ketorolacl(Toradol)lIM

Q:lWhichlNSAIDslhavelalrapidlonsetloflactionlandlarelusedlforlacutelpain

Answer:
naproxen,libuprofen,lfenoprofen,lindomethacin,letodolac,landlpiroxicamlhavelanlonsetloflaction
lofl30-60lmin

Q:lWhichlNSAIDlhaslallongldurationloflactionlandlislusefullinlchroniclpain

Answer:

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Final Exam: NURS617/ NURS 617 (Latest 2024/ 2025 Update) Pharmacotherapeutics Guide| Qs & As| Grade A| 100% Correct (Verified Answers)- Southeastern Louisiana

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