Pharmacology - pANCE review Questions and Answers A+ guide

Pharmacology - pANCE review Questions
and Answers A+ guide

IRreversible platelet effect - correct answers✅✅Aspirin
(acetylsalicylic acid = ASA


Kids with viral infection
- give aspirin ---> will cause - correct answers✅✅Reye's
syndrome


*ASA Triad (asthma, nasal polyps)
caution will cause _____ in ___ patients - correct
answers✅✅bronchospam in asthma patients


medication that Antagonizes vitamin K - correct
answers✅✅Warfarin


reverse warfarin in
• Non-Life-Threatening Hemorrhage - correct answers✅✅ORAL
vitamin K1 (phytonadione)


reverse warfarin in
Life-Threatening Hemorrhage - correct answers✅✅** IV
vitamin K ...plus
+ Prothrombin complex concentrates (PCC) > fresh frozen
plasma (FFP)


- Prevention & treatment of thrombosis /embolism

,Pharmacology - pANCE review Questions
and Answers A+ guide

- Atrial fibrillation - correct answers✅✅Warfarin


Warfarin interactions - correct answers✅✅CYP enzymes
(CYP2C9)
2C9 - important!
• ABX often cause issues with warfarin


Warfarin pregnancy category - correct answers✅✅X -
teratogenic


Mechanism of action =
Indirect thrombin inhibitor - correct answers✅✅Unfractionated
Heparin


Reversal of Heparin
(longer to clot with med b/c "blood thinner") - correct
answers✅✅Protamine
(if urgent reversal required)


Adverse drug reaction of heparin - correct answers✅✅•
Heparin-induced thrombocytopenia (decreased platelets)
aka... HIT syndrome


Inactivates factor Xa - correct answers✅✅Low molecular
weight heparin

,Pharmacology - pANCE review Questions
and Answers A+ guide

ex) enoxaparin


enoxaparin pregnancy category - correct answers✅✅B


New agents for anticoagulation - correct
answers✅✅Rivaroxaban (Xarelto)("-aban" drugs)
** can't reverse any of these


statin drugs
- adverse reaction / SE - correct answers✅✅Myalgia myopathy


Statin drug
- pregnancy category - correct answers✅✅X - teratogenic


Fibrate drugs
- names and use - correct answers✅✅Gemfibrozil &
fenofibrate
TX = hypertriglyceridemia (high triglycerides)


fibrate: Gemfibrozil & fenofibrate
adverse drug reactions - correct answers✅✅• Reversible
hepatotoxicity
• Myopathy

, Pharmacology - pANCE review Questions
and Answers A+ guide

Niacin (vitamin B3)
adverse drug reactions - correct answers✅✅- flushing -
Prostaglandin related
- hepatotoxic
- Aggravate glucose intolerance / gout


Anti-Arrhythmics Classification
Class 1 - correct answers✅✅1 = Na+
* modulate or block Na+ channels IA : Quinidine, procainamide,
IB : Lidocaine, mexiletine
IC : Flecainide, propafenone


Anti-Arrhythmics Classification
Class 2 - correct answers✅✅2 = Beta blockers
* inhibit sympathetic activity
-- β-blockers "olol" drugs


Anti-Arrhythmics Classification
Class 3 - correct answers✅✅3 = K+
* block K+ channels
-- Amiodarone, Sotolol


Anti-Arrhythmics Classification