PHRM 4200- Solubility Test With
Complete Solution
Where must a drug be in order to work? - Answer in solution
What is the importance of the blood concentration/time graphs? - Answer important for
therapeutic windows
solvation - Answer the transfer of molecules or ions into the solvent (aka dissolution)
hydration - Answer the transfer of molecules or ions into water (solvation when water is
the solvent)
solubility - Answer the amount of solute needed to form a saturated solution in a given
quantity of solvent and experimental conditions
saturated solution - Answer when no more solid will dissolve and a dynamic equilibrium
exists between the solution and the undissolved solid
At what saturation is a solution in dynamic equilibrium? - Answer saturated solution
precipitation - Answer the opposite of solvation; the solvent cannot accommodate more
solute, so the solute precipitates back into solid form (aka crystallization)
What are the 2 opposing processes? - Answer solvation/dissolution and
precipitation/crystallization
cohesion - Answer attraction between molecules of the same substance
adhesion - Answer attraction between molecules of different substances
intermolecular forces - Answer the ability of the solvent to break up the cohesive forces
between solute particles and create adhesive forces
and the ability of the solute to break apart
What are the 6 types of intermolecular forces? - Answer - ion-dipole
- H bond
- dipole-dipole
- ion-induced dipole
- dipole-induced dipole
- London dispersion forces
Complete Solution
Where must a drug be in order to work? - Answer in solution
What is the importance of the blood concentration/time graphs? - Answer important for
therapeutic windows
solvation - Answer the transfer of molecules or ions into the solvent (aka dissolution)
hydration - Answer the transfer of molecules or ions into water (solvation when water is
the solvent)
solubility - Answer the amount of solute needed to form a saturated solution in a given
quantity of solvent and experimental conditions
saturated solution - Answer when no more solid will dissolve and a dynamic equilibrium
exists between the solution and the undissolved solid
At what saturation is a solution in dynamic equilibrium? - Answer saturated solution
precipitation - Answer the opposite of solvation; the solvent cannot accommodate more
solute, so the solute precipitates back into solid form (aka crystallization)
What are the 2 opposing processes? - Answer solvation/dissolution and
precipitation/crystallization
cohesion - Answer attraction between molecules of the same substance
adhesion - Answer attraction between molecules of different substances
intermolecular forces - Answer the ability of the solvent to break up the cohesive forces
between solute particles and create adhesive forces
and the ability of the solute to break apart
What are the 6 types of intermolecular forces? - Answer - ion-dipole
- H bond
- dipole-dipole
- ion-induced dipole
- dipole-induced dipole
- London dispersion forces
