Nagelhout Pharm 1- Exam 3 UPDATED
Questions and CORRECT Answers
What is the least potent opiate? - CORRECT ANSWER - Codeine.
Relative potency of 0.04 relative to morphine.
T or F. High dose opioids like sufentanil provide all of the requirement of general anesthesia? -
CORRECT ANSWER - False.
Supplemental drugs may be need to achieve amnesia/unconsciousness, relaxation and
sympathetic control.
What is the most potent opioid? - CORRECT ANSWER - Sufentanil
500-1000 as potent as morphine sulfate
Rank these drugs from least potent to most potent-
Meperidine, Fentanil, Codeine, Alfentanil, Sufentanil, Morphine, Remifentanil? - CORRECT
ANSWER - 1. Codeine 0.04
2. Meperidine 0.1
3. Morphine 1
4. Alfentanil 10
5. Fentanil 100
6. Remifentanil 100
7.Sufentanil 1,000
T or F. It's ok to give fentanyl to someone with morphine allergy. - CORRECT
ANSWER - True.
Fentanyl is a piperidine derivative. Morphine is phenantrene alkaloid. Cross allergy occurs to
drugs in the same classes
, T or F. Morphine's metabolite has no significant analgesic activity? - CORRECT
ANSWER - False.
They have significant analgesic activity. Accumulation may occur with repetitive dosing in renal
patient.
Which class of opioids are best to give to asthmatics? - CORRECT ANSWER -
phenylpiperadines (i.e fentanil)
(no histamine release)
Which opioid has a metabolite that is CNS toxic? - CORRECT ANSWER - Meperidine.
metabolite (normeperidine) causes seizure. caution in patient with renal disease or the elderly or
when used repeatedly.
Which opioid is metabolized by non esterase dependent enzymes? - CORRECT
ANSWER - Remifentanil
This happens via hydrolysis of ester bonds in the blood plasma
What is the elimination half life of remifentanil? - CORRECT ANSWER - 5-10 minutes
T or F. Remifentanil has anti shivering property? - CORRECT ANSWER - False.
Only Meperidine has anti shivering property.
Which stimuli requires the highest dose narcotics to achieve no response: skin incision, skin
closure, intubation? - CORRECT ANSWER - Intubation
T or F. Opiates have anti-emetic properties. - CORRECT ANSWER - True.
They inhibit vomiting center especially with repeated doses.
What receptors are responsible for the ventilatory depressing and analgesic effects of opiods? -
CORRECT ANSWER - Mu
Questions and CORRECT Answers
What is the least potent opiate? - CORRECT ANSWER - Codeine.
Relative potency of 0.04 relative to morphine.
T or F. High dose opioids like sufentanil provide all of the requirement of general anesthesia? -
CORRECT ANSWER - False.
Supplemental drugs may be need to achieve amnesia/unconsciousness, relaxation and
sympathetic control.
What is the most potent opioid? - CORRECT ANSWER - Sufentanil
500-1000 as potent as morphine sulfate
Rank these drugs from least potent to most potent-
Meperidine, Fentanil, Codeine, Alfentanil, Sufentanil, Morphine, Remifentanil? - CORRECT
ANSWER - 1. Codeine 0.04
2. Meperidine 0.1
3. Morphine 1
4. Alfentanil 10
5. Fentanil 100
6. Remifentanil 100
7.Sufentanil 1,000
T or F. It's ok to give fentanyl to someone with morphine allergy. - CORRECT
ANSWER - True.
Fentanyl is a piperidine derivative. Morphine is phenantrene alkaloid. Cross allergy occurs to
drugs in the same classes
, T or F. Morphine's metabolite has no significant analgesic activity? - CORRECT
ANSWER - False.
They have significant analgesic activity. Accumulation may occur with repetitive dosing in renal
patient.
Which class of opioids are best to give to asthmatics? - CORRECT ANSWER -
phenylpiperadines (i.e fentanil)
(no histamine release)
Which opioid has a metabolite that is CNS toxic? - CORRECT ANSWER - Meperidine.
metabolite (normeperidine) causes seizure. caution in patient with renal disease or the elderly or
when used repeatedly.
Which opioid is metabolized by non esterase dependent enzymes? - CORRECT
ANSWER - Remifentanil
This happens via hydrolysis of ester bonds in the blood plasma
What is the elimination half life of remifentanil? - CORRECT ANSWER - 5-10 minutes
T or F. Remifentanil has anti shivering property? - CORRECT ANSWER - False.
Only Meperidine has anti shivering property.
Which stimuli requires the highest dose narcotics to achieve no response: skin incision, skin
closure, intubation? - CORRECT ANSWER - Intubation
T or F. Opiates have anti-emetic properties. - CORRECT ANSWER - True.
They inhibit vomiting center especially with repeated doses.
What receptors are responsible for the ventilatory depressing and analgesic effects of opiods? -
CORRECT ANSWER - Mu
