CPHON- HEMATOLOGY EXAM
QUESTIONS AND VERIFIED
ANSWERS
Bone Marrow Failure: examples of - ANSWER Autoimmune hemolytic
anaemia, fancoanaemiani's anaemia, dyskeratosis congenital, watchman-
diamond syndrome
Platelet/ coagulation diseases - ANSWER ITP, Thrombosis, thrombophilia,
haemophilia, VWD
RBC disease: examples - ANSWER SCD, thalassemia, Glucose 6-phosphate
dehydrogenase deficiency, heredity spherocytosis
A child with dysmorphic thumbs is newly dx with myelodysplastic syndrome.
What does the RN anticipate an additional evaluation for? - ANSWER Fanconi
Anemia
Von Willebrand is deficient in. - ANSWER V, W factor
Iron def & Thalassemia: What is the difference in the lab between the two -
ANSWER Iron def- Fe & ferritin levels are low
Thalassemia- Fe & ferritin levels are both normal to high
,3 Factors that increase the risk for thromboembolism - ANSWER Factor V
Leiden
Protein C & S deficiency
Protein C & S are Vitamin K dependent proteins acting as anticoagulants
Thalassemia : How does it gets transmitted genetically? - ANSWER B-Thal =
autosomal recessive
SCD: What is the main symptom of spleenic infarction with SCD disease? -
ANSWER ULQ pain, severe
Pneumocystis Pneumonia: The causative organism of - ANSWER A Fungus
Amylase & lipase: what are they - ANSWER Amylase- breakdown starches
Lipase- digest fats
What electrolytes have an inverse relationship with each other? - ANSWER
potassium - magnesium
Phosphate-calcium
Sodium-water
PTT-fibrinogen
B cells purpose - ANSWER Humoral immunity- makes antibodies, memory
cells
,Eosinophils: purpose - ANSWER Prominent in allergic rxs
Can selectively destroy parasites/ have function in immediate
allergic/hypersensitivity reactions/ produced prifivrinolysin - form fubrinolysin
- digests fibrin- dissolves clots
Stem cells mature into - ANSWER RBC, granulocytes, monocytes,
lymphocytes, plts
Monocytes purpose - ANSWER Phagocytosis
Large phagocytic cells involved in early stage of inflammatory reaction
natural killer cells (NK cells) purpose - ANSWER Destroy viruses &
malignant cells non specifically
Neutrophils function - ANSWER Ingest & kill microorganisms, primary
defense against bacterial infection
Primary defense in infection/phagocytize and kill bacteria
T lymphocytes (T cells) function - ANSWER Cell mediated immunity- attacks
invaders
a lymphocyte
They are circulated through the thymus gland- ralidly- divide & produce T-cells
that are sensituzed to antigen-killer cells- play a role in body's resistance to
proliferation of cancer cells
, Malignant stem cells are - ANSWER Cells that lose the ability to regulate cell
division and differentiate to mature functioning cells
Blasts accumulate where and what does this cause - ANSWER Marrow spaces,
peripheral vasculature, and organs
Normal cell proliferation is blocked d/t lack of space/nutrients
Diploid - ANSWER 46 chromosomes
G6PD: A ______ retic count and _____Coombs test are found in glucose 6
phosphate deficiency - ANSWER High; negative
Pseudodiploid - ANSWER 46 chromosomes with structural changes
Hyperdiploidy and prognosis - ANSWER Fewer than 50 chromosomes and
good prognosis
Platelet life span - ANSWER 7-10 days
Lymphocytes - ANSWER Involved in development of antibodies and delayed
hypersensitivity
RBC lifespan - ANSWER 120 days (4 months)
Hemoglobin broken down into - ANSWER Iron-iron used by bone marrow to
make more RBC and bilirubin which is excreted by liver as bile
QUESTIONS AND VERIFIED
ANSWERS
Bone Marrow Failure: examples of - ANSWER Autoimmune hemolytic
anaemia, fancoanaemiani's anaemia, dyskeratosis congenital, watchman-
diamond syndrome
Platelet/ coagulation diseases - ANSWER ITP, Thrombosis, thrombophilia,
haemophilia, VWD
RBC disease: examples - ANSWER SCD, thalassemia, Glucose 6-phosphate
dehydrogenase deficiency, heredity spherocytosis
A child with dysmorphic thumbs is newly dx with myelodysplastic syndrome.
What does the RN anticipate an additional evaluation for? - ANSWER Fanconi
Anemia
Von Willebrand is deficient in. - ANSWER V, W factor
Iron def & Thalassemia: What is the difference in the lab between the two -
ANSWER Iron def- Fe & ferritin levels are low
Thalassemia- Fe & ferritin levels are both normal to high
,3 Factors that increase the risk for thromboembolism - ANSWER Factor V
Leiden
Protein C & S deficiency
Protein C & S are Vitamin K dependent proteins acting as anticoagulants
Thalassemia : How does it gets transmitted genetically? - ANSWER B-Thal =
autosomal recessive
SCD: What is the main symptom of spleenic infarction with SCD disease? -
ANSWER ULQ pain, severe
Pneumocystis Pneumonia: The causative organism of - ANSWER A Fungus
Amylase & lipase: what are they - ANSWER Amylase- breakdown starches
Lipase- digest fats
What electrolytes have an inverse relationship with each other? - ANSWER
potassium - magnesium
Phosphate-calcium
Sodium-water
PTT-fibrinogen
B cells purpose - ANSWER Humoral immunity- makes antibodies, memory
cells
,Eosinophils: purpose - ANSWER Prominent in allergic rxs
Can selectively destroy parasites/ have function in immediate
allergic/hypersensitivity reactions/ produced prifivrinolysin - form fubrinolysin
- digests fibrin- dissolves clots
Stem cells mature into - ANSWER RBC, granulocytes, monocytes,
lymphocytes, plts
Monocytes purpose - ANSWER Phagocytosis
Large phagocytic cells involved in early stage of inflammatory reaction
natural killer cells (NK cells) purpose - ANSWER Destroy viruses &
malignant cells non specifically
Neutrophils function - ANSWER Ingest & kill microorganisms, primary
defense against bacterial infection
Primary defense in infection/phagocytize and kill bacteria
T lymphocytes (T cells) function - ANSWER Cell mediated immunity- attacks
invaders
a lymphocyte
They are circulated through the thymus gland- ralidly- divide & produce T-cells
that are sensituzed to antigen-killer cells- play a role in body's resistance to
proliferation of cancer cells
, Malignant stem cells are - ANSWER Cells that lose the ability to regulate cell
division and differentiate to mature functioning cells
Blasts accumulate where and what does this cause - ANSWER Marrow spaces,
peripheral vasculature, and organs
Normal cell proliferation is blocked d/t lack of space/nutrients
Diploid - ANSWER 46 chromosomes
G6PD: A ______ retic count and _____Coombs test are found in glucose 6
phosphate deficiency - ANSWER High; negative
Pseudodiploid - ANSWER 46 chromosomes with structural changes
Hyperdiploidy and prognosis - ANSWER Fewer than 50 chromosomes and
good prognosis
Platelet life span - ANSWER 7-10 days
Lymphocytes - ANSWER Involved in development of antibodies and delayed
hypersensitivity
RBC lifespan - ANSWER 120 days (4 months)
Hemoglobin broken down into - ANSWER Iron-iron used by bone marrow to
make more RBC and bilirubin which is excreted by liver as bile
