NBME PATHOLOGY FINAL TEST BANK EXAM
NEWEST 2024 ACTUAL EXAM COMPLETE 300
QUESTIONS AND CORRECT DETAILED ANSWERS
Practice questions for this set
Learn 2 /7 Study with Learn
Cells have invaded the BM using collagenases and hydrolases
(metalloproteinases). Can metastasize of they reach blood or lymphatic
vessels.
Give this one a try later!
Invasive carcinoma: 2 What is associated with high ESR?
What happens if Bcl-2 is
3 4 What is transudate?
overexpressed?
Don't know?
Terms in this set (223)
, Programmed cell death. REQUIRES ATP. Can occur via
the intrinsic or extrinsic pathways, both of which
involve activation of cytosolic caspases which
mediate cellular breakdown. **Unlike necrosis,
apoptosis does not involve significant inflammation.
Involves eosinophilic cytoplasm, cell shrinkage,
Apoptosis:
pyknosis and basophilia, membrane blebbing and
karyorrhexis, and formation of apoptotic bodies
which are phagocytosed. DNA laddering is a
sensitive indicator of apoptosis* Occurs because
during karyorrhexis endonucleases yield 180bp
fragments.
Causes apoptosis of cancer cells because it causes
formation of free radicals which lead to dsDNA
Radiation therapy does
breakage. rapidly dividing cells like skin and GI
what?
mucosa are highly susceptible to radiation-induced
apoptosis.
It's involved in tissue remodeling in embryogenesis.
Often occurs when a regulating factor is withdrawn
from a proliferating cell population. For example, low
Intrinsic pathway of
IL-2 after completion of an immunological reaction
apoptosis: what is its
causes apoptosis of proliferating effector cells. Also
general purpose / when
occurs in response to injury from radiation, toxins,
does it occur?
hypoxia,etc. Changes in proportions of pro- and anti-
apoptotic factors leads to an increase in
mitochondrial permeability and cyt c release.
BAK, BAX, Bcl-2: Which of BAX and BAK are pro. Bcl-2 is anti-apoptotic.
these are pro- and which
are anti-apoptotic?
It prevents cyt c release by binding to an inhibiting
How does Bcl-2 function?
Apaf-1, which normally INDUCES caspases.
This occurs in follicular lymphoma. Apaf-1 is over-
What happens if Bcl-2 is
inhibited which leads to tumorigenesis because of
overexpressed?
lowered caspase activation.
NEWEST 2024 ACTUAL EXAM COMPLETE 300
QUESTIONS AND CORRECT DETAILED ANSWERS
Practice questions for this set
Learn 2 /7 Study with Learn
Cells have invaded the BM using collagenases and hydrolases
(metalloproteinases). Can metastasize of they reach blood or lymphatic
vessels.
Give this one a try later!
Invasive carcinoma: 2 What is associated with high ESR?
What happens if Bcl-2 is
3 4 What is transudate?
overexpressed?
Don't know?
Terms in this set (223)
, Programmed cell death. REQUIRES ATP. Can occur via
the intrinsic or extrinsic pathways, both of which
involve activation of cytosolic caspases which
mediate cellular breakdown. **Unlike necrosis,
apoptosis does not involve significant inflammation.
Involves eosinophilic cytoplasm, cell shrinkage,
Apoptosis:
pyknosis and basophilia, membrane blebbing and
karyorrhexis, and formation of apoptotic bodies
which are phagocytosed. DNA laddering is a
sensitive indicator of apoptosis* Occurs because
during karyorrhexis endonucleases yield 180bp
fragments.
Causes apoptosis of cancer cells because it causes
formation of free radicals which lead to dsDNA
Radiation therapy does
breakage. rapidly dividing cells like skin and GI
what?
mucosa are highly susceptible to radiation-induced
apoptosis.
It's involved in tissue remodeling in embryogenesis.
Often occurs when a regulating factor is withdrawn
from a proliferating cell population. For example, low
Intrinsic pathway of
IL-2 after completion of an immunological reaction
apoptosis: what is its
causes apoptosis of proliferating effector cells. Also
general purpose / when
occurs in response to injury from radiation, toxins,
does it occur?
hypoxia,etc. Changes in proportions of pro- and anti-
apoptotic factors leads to an increase in
mitochondrial permeability and cyt c release.
BAK, BAX, Bcl-2: Which of BAX and BAK are pro. Bcl-2 is anti-apoptotic.
these are pro- and which
are anti-apoptotic?
It prevents cyt c release by binding to an inhibiting
How does Bcl-2 function?
Apaf-1, which normally INDUCES caspases.
This occurs in follicular lymphoma. Apaf-1 is over-
What happens if Bcl-2 is
inhibited which leads to tumorigenesis because of
overexpressed?
lowered caspase activation.
