©THEBRIGHT EXAM SOLUTIONS
11/9/2024 2:18 PM
Pharmacology 5334 Module 3 Exam
Questions And Answers 100% Pass
Maximum amount of Sumatriptan that can be taken in 1 day - answer✔200 mg
The ability of the anesthetic to penetrate the axon membrane is determined by what 3 properties? -
answer✔Lipid solubility, degree of ionization at tissue pH, molecular size
Why is epinephrine given with local anesthetics? - answer✔Decreases local blood flow; delays systemic
absorption of the anesthetic; prolongs anesthesia; reduces the risk of toxicity
Most widely used local anesthetic - answer✔Lidocaine
What is a possible fatal reaction to benzocaine? - answer✔Methemoglobinemia
What is included in application guidelines for topical anesthetics? - answer✔Avoid wrapping the site and
heating the site; avoid application to open skin; use to smallest amount to the smallest site
What is the best option for menstrual migraine? - answer✔Low dose estrogen about 3 days prior to
menses
What are the 3 main classes of opiod receptors? - answer✔Mu, alpha, and delta
Which medication will reverse the effects caused by opioid agonists? - answer✔Naloxone (Narcan)
What medications are used to treat opioid induced constipation (OIC)? - answer✔Naloxegol,
methylinaltrexone, and lubiprostone
Tolerance is defined as: - answer✔increased doses of a medication needed to obtain the same response
Physical dependence is defined as: - answer✔abstinence syndrome with abrupt discontinuation
Abuse is defined as: - answer✔drug use that is inconsistent with medical or social norms
Addiction is defined as: - answer✔behavior pattern characterized by continued use of a psychoactive
substance despite physical, psychologic, or social harm
What medication is used for opioid abuse? - answer✔Naltrexone
, ©THEBRIGHT EXAM SOLUTIONS
11/9/2024 2:18 PM
Euphoria induced by morphine: - answer✔an exaggerated sense of well-being caused by the activation
of mu receptors
What medication is given nasally for migraines? - answer✔Butorphanol
Describe the mechanism of NSAIDs - answer✔Inhibition of the cyclo-oxygenase enzyme
Second generation Cox 2 inhibitors: - answer✔suppress inflammation and cause less risk for GI
ulceration than Cox 1; increase the risk for heart disease
What medication should NOT be given with aspirin? - answer✔Glucocorticoids
What medication is given for acetaminophen overdose? - answer✔Acetylcysteine
What are non-endocrine therapeutic uses for glucocorticoids? - answer✔RA, SLE, IBS, bursitis, OA, gout,
disorders of the eye
What is the danger of prolonged use of glucocorticoids? - answer✔Adrenal insufficiency
Methotrexate can cause fatal toxicities of: - answer✔bone marrow, liver, kidneys, lungs; hemorrhagic
enteritis and GI perforation
What must be checked yearly while taking etanercept? - answer✔TB
What is the mechanism of action of etanercept? - answer✔Suppresses the immune system
First line treatment of gout - answer✔Indomethacin
When would you initiate a uricosuric medication? - answer✔more than 3 gout attacks per year
Moderate-strong opioid agonists - answer✔codeine, oxycodone, hydrocodone, tapentadol
Opioid agonist-antagonist - answer✔Pentazocine, nalbuphine, butorphanol, buprenorpine (prolongs QT)
Non-opioid centrally acting analgesics - answer✔Tramadol (suicide and seizure risk), clonidine,
Ziconotide, dexmetomidine (used for patients on mechanical ventilation)
Non-Aspirin First Generation NSAIDs - answer✔Ibuprofen, naproxen. SAFETY ALERT: all first-generation
NSAIDs are associated with an increased risk of GI blessing that can lead to hospitalization or death
2nd generation NSAIDs - answer✔Celecoxib, meloxican
Risks for NSAIDs - answer✔Heart disease, renal function, and GI bleeding. Cox-2 poses less risk for GI
bleeding
Rheumatoid arthritis (RA) - answer✔Chronic systemic inflammation including the synovial membranes
of multiple joints; shortens lifespan and increases risk of cardiovascular events and stroke; goal of
treatment is to reduce inflammation and pain while preserving function and preventing deformity
11/9/2024 2:18 PM
Pharmacology 5334 Module 3 Exam
Questions And Answers 100% Pass
Maximum amount of Sumatriptan that can be taken in 1 day - answer✔200 mg
The ability of the anesthetic to penetrate the axon membrane is determined by what 3 properties? -
answer✔Lipid solubility, degree of ionization at tissue pH, molecular size
Why is epinephrine given with local anesthetics? - answer✔Decreases local blood flow; delays systemic
absorption of the anesthetic; prolongs anesthesia; reduces the risk of toxicity
Most widely used local anesthetic - answer✔Lidocaine
What is a possible fatal reaction to benzocaine? - answer✔Methemoglobinemia
What is included in application guidelines for topical anesthetics? - answer✔Avoid wrapping the site and
heating the site; avoid application to open skin; use to smallest amount to the smallest site
What is the best option for menstrual migraine? - answer✔Low dose estrogen about 3 days prior to
menses
What are the 3 main classes of opiod receptors? - answer✔Mu, alpha, and delta
Which medication will reverse the effects caused by opioid agonists? - answer✔Naloxone (Narcan)
What medications are used to treat opioid induced constipation (OIC)? - answer✔Naloxegol,
methylinaltrexone, and lubiprostone
Tolerance is defined as: - answer✔increased doses of a medication needed to obtain the same response
Physical dependence is defined as: - answer✔abstinence syndrome with abrupt discontinuation
Abuse is defined as: - answer✔drug use that is inconsistent with medical or social norms
Addiction is defined as: - answer✔behavior pattern characterized by continued use of a psychoactive
substance despite physical, psychologic, or social harm
What medication is used for opioid abuse? - answer✔Naltrexone
, ©THEBRIGHT EXAM SOLUTIONS
11/9/2024 2:18 PM
Euphoria induced by morphine: - answer✔an exaggerated sense of well-being caused by the activation
of mu receptors
What medication is given nasally for migraines? - answer✔Butorphanol
Describe the mechanism of NSAIDs - answer✔Inhibition of the cyclo-oxygenase enzyme
Second generation Cox 2 inhibitors: - answer✔suppress inflammation and cause less risk for GI
ulceration than Cox 1; increase the risk for heart disease
What medication should NOT be given with aspirin? - answer✔Glucocorticoids
What medication is given for acetaminophen overdose? - answer✔Acetylcysteine
What are non-endocrine therapeutic uses for glucocorticoids? - answer✔RA, SLE, IBS, bursitis, OA, gout,
disorders of the eye
What is the danger of prolonged use of glucocorticoids? - answer✔Adrenal insufficiency
Methotrexate can cause fatal toxicities of: - answer✔bone marrow, liver, kidneys, lungs; hemorrhagic
enteritis and GI perforation
What must be checked yearly while taking etanercept? - answer✔TB
What is the mechanism of action of etanercept? - answer✔Suppresses the immune system
First line treatment of gout - answer✔Indomethacin
When would you initiate a uricosuric medication? - answer✔more than 3 gout attacks per year
Moderate-strong opioid agonists - answer✔codeine, oxycodone, hydrocodone, tapentadol
Opioid agonist-antagonist - answer✔Pentazocine, nalbuphine, butorphanol, buprenorpine (prolongs QT)
Non-opioid centrally acting analgesics - answer✔Tramadol (suicide and seizure risk), clonidine,
Ziconotide, dexmetomidine (used for patients on mechanical ventilation)
Non-Aspirin First Generation NSAIDs - answer✔Ibuprofen, naproxen. SAFETY ALERT: all first-generation
NSAIDs are associated with an increased risk of GI blessing that can lead to hospitalization or death
2nd generation NSAIDs - answer✔Celecoxib, meloxican
Risks for NSAIDs - answer✔Heart disease, renal function, and GI bleeding. Cox-2 poses less risk for GI
bleeding
Rheumatoid arthritis (RA) - answer✔Chronic systemic inflammation including the synovial membranes
of multiple joints; shortens lifespan and increases risk of cardiovascular events and stroke; goal of
treatment is to reduce inflammation and pain while preserving function and preventing deformity
