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PCB 3233 Exam 2 questions with answers

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PCB 3233 Exam 2 questions with answers

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PCB 3233 Exam 2 questions with answers


What are two cells that use receptors to distinguish between self and non-self cells? - ** VERIFIED
ANSWERS **✔✔-Macrophages

-NK Cells



C3b is a ligand for - ** VERIFIED ANSWERS **✔✔Macrophage CR1



CR3 & CR4 - ** VERIFIED ANSWERS **✔✔Recognize iC3b & other ligands including LPS



Lectins - ** VERIFIED ANSWERS **✔✔Carbohydrates-binding proteins

ex: Mannose & glucose receptors



Scavenger Receptors - ** VERIFIED ANSWERS **✔✔Prefer molecules that are negatively charged
like nucleic acids, LPS.



Phagocytic Receptors - ** VERIFIED ANSWERS **✔✔Bind directly to microbial surface
components



What do surface receptors promote? - ** VERIFIED ANSWERS **✔✔Phagocytosis



PRR's bind to - ** VERIFIED ANSWERS **✔✔PAMPs on pathogens



Receptors that detect microbial products signal what? - ** VERIFIED ANSWERS **✔✔-Macrophage
activation

-Cytokine Secretion



Toll-Like Receptors (TLR) - ** VERIFIED ANSWERS **✔✔-10 receptors

, -Has specificities for several microbial products



TLR-4 - ** VERIFIED ANSWERS **✔✔-Senses LPS

-Found on macrophages



What can LPS cause? - ** VERIFIED ANSWERS **✔✔Septic Shock



What is LPS known for being? - ** VERIFIED ANSWERS **✔✔Endotoxin



What is local accumulation of fluid accompanied by? - ** VERIFIED ANSWERS **✔✔Swelling,
redness, heat, & pain



What does increased dilation cause? - ** VERIFIED ANSWERS **✔✔Reduced blood flow



Complement receptors 3&4 (Mac-1, CD11b, CD8) target what? - ** VERIFIED ANSWERS
**✔✔Bacteria & Fungi



CD14 binds to what? - ** VERIFIED ANSWERS **✔✔-LPS

-Peptidoglycan



What does IL-8 (CXCL-8) do? - ** VERIFIED ANSWERS **✔✔Attracts leukocytes (neutrophils) to
the site of infection/damage



What are your proinflammatory cytokines? - ** VERIFIED ANSWERS **✔✔-IL-1Beta

-IL-6

-CXCL8 (IL-8)

-IL-12

-TNF Alpha

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