PCB 3233 - Immunology - Exam 2 (Dr. Ambivero) questions
with correct answers
Induced Innate Response - ** VERIFIED ANSWERS **✔✔Takes place once the pathogen has
breached the physical barriers and outrun the initial response
Macrophages, NK Cells - ** VERIFIED ANSWERS **✔✔Two cells that use receptors to distinguish
between self and non-self cells
Macrophage CR1 - ** VERIFIED ANSWERS **✔✔C3b is a ligand for
CR3, CR4 - ** VERIFIED ANSWERS **✔✔Recognize iC3b & other ligands including LPS
Lectins - ** VERIFIED ANSWERS **✔✔Carbohydrates-binding proteins
ex: Mannose & glucose receptors
Scavenger Receptors - ** VERIFIED ANSWERS **✔✔Prefer molecules that are negatively charged
like nucleic acids, LPS.
Phagocytic Receptors - ** VERIFIED ANSWERS **✔✔Bind directly to microbial surface
components
Phagocytosis - ** VERIFIED ANSWERS **✔✔Promoted by surface receptors promote
PAMPs on pathogens - ** VERIFIED ANSWERS **✔✔PRR's bind to
Macrophage activation, Cytokine Secretion - ** VERIFIED ANSWERS **✔✔Receptors that detect
microbial products signal _____ and ______
,Toll-Like Receptors (TLR) - ** VERIFIED ANSWERS **✔✔-10 receptors
-Has specificities for several microbial products
TLR-4 - ** VERIFIED ANSWERS **✔✔-Senses LPS
-Found on macrophages
Septic Shock - ** VERIFIED ANSWERS **✔✔What can LPS cause?
Endotoxin - ** VERIFIED ANSWERS **✔✔Other than a lipoglycan, what is another denomination
attributed to LPS?
Swelling, redness, heat, & pain - ** VERIFIED ANSWERS **✔✔Characteristics of Inflammation
Reduced blood flow - ** VERIFIED ANSWERS **✔✔What does increased vasodilation cause?
Bacteria, Fungi - ** VERIFIED ANSWERS **✔✔Complement receptors 3&4 (Mac-1, CD11b, CD8)
target what?
LPS, Peptidoglycan - ** VERIFIED ANSWERS **✔✔CD14 binds to what?
Attracts leukocytes (neutrophils) to the site of infection/damage - ** VERIFIED ANSWERS
**✔✔What does IL-8 (CXCL-8) do?
IL-1Beta, IL-6, IL-12, CXCL8 (IL-8), TNF-Alpha - ** VERIFIED ANSWERS **✔✔Proinflammatory
cytokines
TLR-7 - ** VERIFIED ANSWERS **✔✔-Ligand: Single stranded viral RNA
-Detects RNA viruses
-Carried by dendritic cells, NK cells, eosinophils, & B-cells
, TLR-5 - ** VERIFIED ANSWERS **✔✔-Ligand is Flagellin
-Found in plasma membrane
-Carried by intestinal & epithelial cells
TLR-3 - ** VERIFIED ANSWERS **✔✔-Ligand: Double stranded viral RNA
-Carried by NK cells
TLR-4 - ** VERIFIED ANSWERS **✔✔-LPS
-Recognizes gram negative bacteria
-Carried by macrophages, mast cells, dendritic cells & eosinophils
MyD88 - ** VERIFIED ANSWERS **✔✔Adaptor protein for TLR signaling
Acts on muscle to increase temperature - ** VERIFIED ANSWERS **✔✔Function of IL-6
Works with TNF-A to activate endothelial cells & induce inflammation - ** VERIFIED ANSWERS
**✔✔Function of IL-1Beta
Activates NK Cells - ** VERIFIED ANSWERS **✔✔Function of IL-2
NOD-1 - ** VERIFIED ANSWERS **✔✔Recognizes gram (-) peptidoglycan
NOD-2 - ** VERIFIED ANSWERS **✔✔Recognizes muramyl dipeptide
Receptors in the cytoplasm that recognize pathogens - ** VERIFIED ANSWERS **✔✔What are
NOD-like receptors?
Infected tissue - ** VERIFIED ANSWERS **✔✔Site of Monocyte Maturation
with correct answers
Induced Innate Response - ** VERIFIED ANSWERS **✔✔Takes place once the pathogen has
breached the physical barriers and outrun the initial response
Macrophages, NK Cells - ** VERIFIED ANSWERS **✔✔Two cells that use receptors to distinguish
between self and non-self cells
Macrophage CR1 - ** VERIFIED ANSWERS **✔✔C3b is a ligand for
CR3, CR4 - ** VERIFIED ANSWERS **✔✔Recognize iC3b & other ligands including LPS
Lectins - ** VERIFIED ANSWERS **✔✔Carbohydrates-binding proteins
ex: Mannose & glucose receptors
Scavenger Receptors - ** VERIFIED ANSWERS **✔✔Prefer molecules that are negatively charged
like nucleic acids, LPS.
Phagocytic Receptors - ** VERIFIED ANSWERS **✔✔Bind directly to microbial surface
components
Phagocytosis - ** VERIFIED ANSWERS **✔✔Promoted by surface receptors promote
PAMPs on pathogens - ** VERIFIED ANSWERS **✔✔PRR's bind to
Macrophage activation, Cytokine Secretion - ** VERIFIED ANSWERS **✔✔Receptors that detect
microbial products signal _____ and ______
,Toll-Like Receptors (TLR) - ** VERIFIED ANSWERS **✔✔-10 receptors
-Has specificities for several microbial products
TLR-4 - ** VERIFIED ANSWERS **✔✔-Senses LPS
-Found on macrophages
Septic Shock - ** VERIFIED ANSWERS **✔✔What can LPS cause?
Endotoxin - ** VERIFIED ANSWERS **✔✔Other than a lipoglycan, what is another denomination
attributed to LPS?
Swelling, redness, heat, & pain - ** VERIFIED ANSWERS **✔✔Characteristics of Inflammation
Reduced blood flow - ** VERIFIED ANSWERS **✔✔What does increased vasodilation cause?
Bacteria, Fungi - ** VERIFIED ANSWERS **✔✔Complement receptors 3&4 (Mac-1, CD11b, CD8)
target what?
LPS, Peptidoglycan - ** VERIFIED ANSWERS **✔✔CD14 binds to what?
Attracts leukocytes (neutrophils) to the site of infection/damage - ** VERIFIED ANSWERS
**✔✔What does IL-8 (CXCL-8) do?
IL-1Beta, IL-6, IL-12, CXCL8 (IL-8), TNF-Alpha - ** VERIFIED ANSWERS **✔✔Proinflammatory
cytokines
TLR-7 - ** VERIFIED ANSWERS **✔✔-Ligand: Single stranded viral RNA
-Detects RNA viruses
-Carried by dendritic cells, NK cells, eosinophils, & B-cells
, TLR-5 - ** VERIFIED ANSWERS **✔✔-Ligand is Flagellin
-Found in plasma membrane
-Carried by intestinal & epithelial cells
TLR-3 - ** VERIFIED ANSWERS **✔✔-Ligand: Double stranded viral RNA
-Carried by NK cells
TLR-4 - ** VERIFIED ANSWERS **✔✔-LPS
-Recognizes gram negative bacteria
-Carried by macrophages, mast cells, dendritic cells & eosinophils
MyD88 - ** VERIFIED ANSWERS **✔✔Adaptor protein for TLR signaling
Acts on muscle to increase temperature - ** VERIFIED ANSWERS **✔✔Function of IL-6
Works with TNF-A to activate endothelial cells & induce inflammation - ** VERIFIED ANSWERS
**✔✔Function of IL-1Beta
Activates NK Cells - ** VERIFIED ANSWERS **✔✔Function of IL-2
NOD-1 - ** VERIFIED ANSWERS **✔✔Recognizes gram (-) peptidoglycan
NOD-2 - ** VERIFIED ANSWERS **✔✔Recognizes muramyl dipeptide
Receptors in the cytoplasm that recognize pathogens - ** VERIFIED ANSWERS **✔✔What are
NOD-like receptors?
Infected tissue - ** VERIFIED ANSWERS **✔✔Site of Monocyte Maturation
