©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
USMLE Step 1 Rapid Review Study Guide
Solutions
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - ANSWER✔✔-Budd-Chiari
syndrome
Achilles tendon xanthoma - ANSWER✔✔-Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - ANSWER✔✔-Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - ANSWER✔✔-Marfan's (fibrillin
defect)
Athlete with polycythemia - ANSWER✔✔-Erythropoietin injection
Back pain, fever, night sweats, weight loss - ANSWER✔✔-Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - ANSWER✔✔-Sarcoid
Blue sclera - ANSWER✔✔-Osteogenesis imperfecta
Bluish line on gingiva - ANSWER✔✔-Burton's line - lead poisoning
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, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) -
ANSWER✔✔-Paget's
Bounding pulses, diastolic hear murmur, head bobbing - ANSWER✔✔-Aortic regurg
Café-au-lait spots, Lisch nodules - ANSWER✔✔-NF (1 = optic glimoas and pheo, 2 = acoustic
Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - ANSWER✔✔-McCune-Albright
syndome (G protein problem)
Calf pseudohypertrophy - ANSWER✔✔-Duchenne's muscular dystrophy
Cherry-red spot on macula - ANSWER✔✔-Tay-Sachs, Niemann-Pick, central retinal artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - ANSWER✔✔-Dressler's
(autoimmune post-MI)
Child uses arms to stand up from squat - ANSWER✔✔-Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - ANSWER✔✔-Slapped cheek - B19
Chorea, dementia, caudate degeneration - ANSWER✔✔-Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - ANSWER✔✔-McArdle's (muscle
phosphorylase deficiency)
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, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Cold intolerance - ANSWER✔✔-Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - ANSWER✔✔-Internuclear ophthalmoplegia (MS or
stroke)
Continuous machinery heart murmur - ANSWER✔✔-PDA
Cutaneous/dermal edema due to CT expansion - ANSWER✔✔-Myxedema
Dark purple skin / mouth nodules - ANSWER✔✔-Kaposi's sarcoma
Deep, labored breathing / hyperventilation - ANSWER✔✔-Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - ANSWER✔✔-Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - ANSWER✔✔-Wet beriberi (B1 / thiamine deficiency)
Dog or cat bite resulting in infection - ANSWER✔✔-Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis - ANSWER✔✔-Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia - ANSWER✔✔-
Plummer-Vinson syndrome
Elastic skin, hypermobility of joints - ANSWER✔✔-Ehler-Danlos (type III collagen)
Page 3/20
FIRST PUBLISH OCTOBER 2024
USMLE Step 1 Rapid Review Study Guide
Solutions
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - ANSWER✔✔-Budd-Chiari
syndrome
Achilles tendon xanthoma - ANSWER✔✔-Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - ANSWER✔✔-Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - ANSWER✔✔-Marfan's (fibrillin
defect)
Athlete with polycythemia - ANSWER✔✔-Erythropoietin injection
Back pain, fever, night sweats, weight loss - ANSWER✔✔-Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - ANSWER✔✔-Sarcoid
Blue sclera - ANSWER✔✔-Osteogenesis imperfecta
Bluish line on gingiva - ANSWER✔✔-Burton's line - lead poisoning
Page 1/20
, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) -
ANSWER✔✔-Paget's
Bounding pulses, diastolic hear murmur, head bobbing - ANSWER✔✔-Aortic regurg
Café-au-lait spots, Lisch nodules - ANSWER✔✔-NF (1 = optic glimoas and pheo, 2 = acoustic
Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - ANSWER✔✔-McCune-Albright
syndome (G protein problem)
Calf pseudohypertrophy - ANSWER✔✔-Duchenne's muscular dystrophy
Cherry-red spot on macula - ANSWER✔✔-Tay-Sachs, Niemann-Pick, central retinal artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - ANSWER✔✔-Dressler's
(autoimmune post-MI)
Child uses arms to stand up from squat - ANSWER✔✔-Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - ANSWER✔✔-Slapped cheek - B19
Chorea, dementia, caudate degeneration - ANSWER✔✔-Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - ANSWER✔✔-McArdle's (muscle
phosphorylase deficiency)
Page 2/20
, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Cold intolerance - ANSWER✔✔-Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - ANSWER✔✔-Internuclear ophthalmoplegia (MS or
stroke)
Continuous machinery heart murmur - ANSWER✔✔-PDA
Cutaneous/dermal edema due to CT expansion - ANSWER✔✔-Myxedema
Dark purple skin / mouth nodules - ANSWER✔✔-Kaposi's sarcoma
Deep, labored breathing / hyperventilation - ANSWER✔✔-Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - ANSWER✔✔-Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - ANSWER✔✔-Wet beriberi (B1 / thiamine deficiency)
Dog or cat bite resulting in infection - ANSWER✔✔-Pasteurella multocida (local cellulitis)
Dry eyes, dry mouth, arthritis - ANSWER✔✔-Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia - ANSWER✔✔-
Plummer-Vinson syndrome
Elastic skin, hypermobility of joints - ANSWER✔✔-Ehler-Danlos (type III collagen)
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