D027 NURS 5204
Advanced Pathopharmacological
Foundations
COMPREHENSIVE FA EXAM
Q&S
©2024/2025
,1. A patient with chronic heart failure is prescribed Digoxin.
Which mechanism of action is primarily responsible for its
therapeutic effect?
- A) Inhibition of angiotensin-converting enzyme
- B) Blockade of beta-adrenergic receptors
- C) Inhibition of sodium-potassium ATPase
- D) Stimulation of nitric oxide release
Answer: C) Inhibition of sodium-potassium ATPase
Rationale: Digoxin works by inhibiting the sodium-
potassium ATPase pump, leading to an increase in
intracellular calcium and enhanced cardiac contractility.
2. In managing Parkinson's disease, the rationale for using
Levodopa is that it:
- A) Decreases acetylcholine levels
- B) Increases dopamine levels in the brain
- C) Prevents oxidative stress in neurons
- D) Blocks NMDA receptors
Answer: B) Increases dopamine levels in the brain
Rationale: Levodopa acts as a precursor to dopamine,
thereby increasing dopamine levels and improving
symptoms in Parkinsonian patients.
3. Which of the following antihypertensive agents is most
likely to cause a persistent dry cough as a side effect?
- A) Losartan
- B) Lisinopril
- C) Amlodipine
- D) Hydrochlorothiazide
©2024/2025
, Answer: B) Lisinopril
Rationale: ACE inhibitors like Lisinopril can cause a dry
cough due to the accumulation of bradykinin.
### Fill-in-the-Blank
4. The main adverse effects of statins include __________
and myopathy.
Answer: Hepatotoxicity
Rationale: Statins can cause liver damage and muscle
pain/weakness.
5. ____________ is a monoclonal antibody used in the
treatment of HER2 positive breast cancer.
Answer: Trastuzumab
Rationale: Trastuzumab specifically targets the HER2
receptor on breast cancer cells, slowing tumor growth.
### True/False
6. True or False: Insulin glargine is a short-acting insulin
used primarily for mealtime glucose control.
Answer: False
Rationale: Insulin glargine is a long-acting insulin used to
provide basal glucose control.
7. True or False: Beta-blockers are contraindicated in
patients with asthma due to possible bronchoconstriction.
©2024/2025
Advanced Pathopharmacological
Foundations
COMPREHENSIVE FA EXAM
Q&S
©2024/2025
,1. A patient with chronic heart failure is prescribed Digoxin.
Which mechanism of action is primarily responsible for its
therapeutic effect?
- A) Inhibition of angiotensin-converting enzyme
- B) Blockade of beta-adrenergic receptors
- C) Inhibition of sodium-potassium ATPase
- D) Stimulation of nitric oxide release
Answer: C) Inhibition of sodium-potassium ATPase
Rationale: Digoxin works by inhibiting the sodium-
potassium ATPase pump, leading to an increase in
intracellular calcium and enhanced cardiac contractility.
2. In managing Parkinson's disease, the rationale for using
Levodopa is that it:
- A) Decreases acetylcholine levels
- B) Increases dopamine levels in the brain
- C) Prevents oxidative stress in neurons
- D) Blocks NMDA receptors
Answer: B) Increases dopamine levels in the brain
Rationale: Levodopa acts as a precursor to dopamine,
thereby increasing dopamine levels and improving
symptoms in Parkinsonian patients.
3. Which of the following antihypertensive agents is most
likely to cause a persistent dry cough as a side effect?
- A) Losartan
- B) Lisinopril
- C) Amlodipine
- D) Hydrochlorothiazide
©2024/2025
, Answer: B) Lisinopril
Rationale: ACE inhibitors like Lisinopril can cause a dry
cough due to the accumulation of bradykinin.
### Fill-in-the-Blank
4. The main adverse effects of statins include __________
and myopathy.
Answer: Hepatotoxicity
Rationale: Statins can cause liver damage and muscle
pain/weakness.
5. ____________ is a monoclonal antibody used in the
treatment of HER2 positive breast cancer.
Answer: Trastuzumab
Rationale: Trastuzumab specifically targets the HER2
receptor on breast cancer cells, slowing tumor growth.
### True/False
6. True or False: Insulin glargine is a short-acting insulin
used primarily for mealtime glucose control.
Answer: False
Rationale: Insulin glargine is a long-acting insulin used to
provide basal glucose control.
7. True or False: Beta-blockers are contraindicated in
patients with asthma due to possible bronchoconstriction.
©2024/2025
